2019
DOI: 10.1016/j.sab.2019.02.010
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Determination of cobalt compounds in dietary supplements using liquid chromatography inductively coupled plasma mass spectrometry

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Cited by 11 publications
(3 citation statements)
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“…The structures of cobalamins possess a characteristic cobalt atom in the corrin ring, which allows for the analysis using ICP-MS by monitoring the cobalt. A few publications [83][84][85][86][87][88][89][90][91] have been reported using hyphenated ICP-MS techniques for analysing naturally occurring cobalamins in foods ever since Chassaigne and Lobinski [92] first applied the LC-ICP-MS for determination of cobalamins in pharmaceutical preparations. It is clearly observed that the outstanding sensitivity of ICP-MS enables the detection of low levels of cobalamins in their native forms without pre-concentrating by cyanidation, and HPLC or other functionally similar separation techniques such as capillary electrophoresis or size exclusion chromatography could realize necessary separation between different cobalamins for cobalt speciation.…”
Section: Lc-icp-msmentioning
confidence: 99%
“…The structures of cobalamins possess a characteristic cobalt atom in the corrin ring, which allows for the analysis using ICP-MS by monitoring the cobalt. A few publications [83][84][85][86][87][88][89][90][91] have been reported using hyphenated ICP-MS techniques for analysing naturally occurring cobalamins in foods ever since Chassaigne and Lobinski [92] first applied the LC-ICP-MS for determination of cobalamins in pharmaceutical preparations. It is clearly observed that the outstanding sensitivity of ICP-MS enables the detection of low levels of cobalamins in their native forms without pre-concentrating by cyanidation, and HPLC or other functionally similar separation techniques such as capillary electrophoresis or size exclusion chromatography could realize necessary separation between different cobalamins for cobalt speciation.…”
Section: Lc-icp-msmentioning
confidence: 99%
“…In the first paper HPLC-ICP-MS was employed to determine Co compounds in dietary supplements. 104 Separation was performed using an HPLC system equipped with a RP C8 column (21 mm × 150 mm, 5 μm) and a gradient elution using ACN as mobile phase A and 8 mmol L −1 NH 4 AC (pH = 4.0) as mobile phase B flowing at 0.12 mL min −1 . A membrane desolvation system was applied to remove the organic solvent load on the plasma.…”
Section: Elemental Speciation Analysismentioning
confidence: 99%
“…Excretion studies with either CoCl 2 or cyanocobalamin were conducted with two separate groups of healthy volunteers, and urine as well as EDTA whole blood samples were frequently collected over a period of 30 days. In this proof‐of‐concept study, a test method enabling the separation and detection of cobalt‐containing organic analytes and unbound cobalt in human urine within one single analytical run was adapted as a simplified screening from former publications 21–24 utilizing high performance liquid chromatography (HPLC) combined with ICP‐MS. The approach aims at facilitating the immediate attribution of measured urinary cobalt concentrations to either the legitimate use of cyanocobalamin or the prohibited use of, for example, cobalt salts.…”
Section: Introductionmentioning
confidence: 99%