Determination of coccidiostat clopidol on an electropolymerized-molecularly imprinted polypyrrole polymer modified screen printed carbon electrode

Radi, Abd-Elgawad; El-Naggar, Abd-Elrahman; Nassef, Hossam M.

doi:10.1039/c4ay01320d

Cited by 21 publications

(11 citation statements)

References 38 publications

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“…In this sensor, multi-walled carbon nanotubes and silica nanoparticles provided multi-porous network structure, which increased the accessibility of analyte (epinephrine) towards imprinted sites. Screen printed carbon electrodes were modified by clopidol-imprinted Ppy structures, which were electro-deposited from water-based solution containing both pyrrole and clopidol [ 104 ]. For the determination of analytical signal by this sensor differential pulse voltammetry was applied.…”

Section: Advantages Of Electrochemical Conducting Polymer Based Lamentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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Recent challenges in biomedical diagnostics show that the development of rapid affinity sensors is very important issue. Therefore, in this review we are aiming to outline the most important directions of affinity sensors where polymer-based semiconducting materials are applied. Progress in formation and development of such materials is overviewed and discussed. Some applicability aspects of conducting polymers in the design of affinity sensors are presented. The main attention is focused on bioanalytical application of conducting polymers such as polypyrrole, polyaniline, polythiophene and poly(3,4-ethylenedioxythiophene) ortho-phenylenediamine. In addition, some other polymers and inorganic materials that are suitable for molecular imprinting technology are also overviewed. Polymerization techniques, which are the most suitable for the development of composite structures suitable for affinity sensors are presented. Analytical signal transduction methods applied in affinity sensors based on polymer-based semiconducting materials are discussed. In this review the most attention is focused on the development and application of molecularly imprinted polymer-based structures, which can replace antibodies, receptors, and many others expensive affinity reagents. The applicability of electrochromic polymers in affinity sensor design is envisaged. Sufficient biocompatibility of some conducting polymers enables to apply them as “stealth coatings” in the future implantable affinity-sensors. Some new perspectives and trends in analytical application of polymer-based semiconducting materials are highlighted.

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Section: Advantages Of Electrochemical Conducting Polymer Based Lamentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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“…Additional coupling reactions, which result in trimers or hexamers, may occur with increasing monomer concentration. Examples of templates used for polypyrrole imprinting include caffeine [ 11 , 12 , 13 ], glutamic acid [ 14 ], sodium taurocholate [ 15 ], L-aspartic acid [ 16 ], adenosine, inosine and ATP [ 17 ], adeoxynivalenol [ 18 ], dopamine [ 19 , 20 ], quercetin [ 21 ], clopidol [ 22 ], gliclazide [ 23 ], sulfanilamide [ 24 ], and sulfadimethoxine [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid

Schweiger

Kim

et al. 2015

Sensors

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Piezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight estimations revealed a decrease of the polymerization rate with increasing clofibric acid concentration. XPS measurements indicated that clofibric acid could be removed after imprinting with an aqueous ethanol solution, which was further optimized by using PAD. Zeta potential and contact angle measurements revealed differences between molecularly imprinted (MIP) and non-imprinted polymer (NIP) layers. Binding experiments with clofibric acid and other substances showed a pronounced selectivity of the MIP for clofibric acid vs. carbamazepine, but the response of MIP and NIP to 2,4-dichlorophenoxyacetic acid was higher than that for clofibric acid. A smooth surface, revealed by AFM measurements, with roughness of 6–8 nm for imprinted and non-imprinted layers, might be a reason for an excessively low density of specific binding sites for clofibric acid. Furthermore, the decreased polymerization rate in the presence of clofibric acid might not result in well-defined polymer structures, which could be the reason for the lower sensitivity.

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“…Even in cases where thin layer imprinted polymers have been employed, a multistep fabrication is needed, where the initiators must be graed on the surface of the microspheres being encapsulated. [22][23][24][25][26][27][28][29][30] The 2 electrode design reproducibility and recoveries were evaluated by analysis of wine spiked with 5 mg L À1 of resveratrol as described earlier. Four different electrodes prepared under the same conditions were used to analyze the standard.…”

Section: Resultsmentioning

confidence: 99%