Determination of critical-sized defect of mandible in a rabbit model: Micro-computed tomography, and histological evaluation

Wang, Y.; Zhang, Xiaoyan; Mei, Shuang; Li, Yunlong; Khan, Abdul Ghaffar; Guan, Shuai; Li, Xiangjun

doi:10.1016/j.heliyon.2023.e18047

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…In another experiment in the mandible of rabbits, box-shaped defects of 3 mm in width and 2 mm in depth were made [33]. The boxes were prepared by applying different diameters, that is 4, 5, 6, 8, and 10mm.…”

Section: Discussionmentioning

confidence: 99%

Critical-sized marginal defects around implants treated with xenografts in rabbits

Asano,

Xavier,

Silva

et al. 2023

Preprint

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Background: Healing of critical-size defects is a well-known problem that has been challenged in several studies. The aim of the experiment was to evaluate bone formation and osseointegration of implants installed in critical defects of the mandibular body simultaneously grafted with Bio-Oss® or Cerabone®. Material and methods: Defects, 10 mm wide and 3 mm deep, were prepared at both lateral aspects of the mandible in 12 rabbits. One implant was installed in the center of the defect, and bovine xenografts produced either at low (Bio-Oss®; Low-T) or high (Cerabone®; High-T) temperatures were used to fill the defects. A collagen membrane was placed to cover the sites. Healing was evaluated 10 weeks after surgery. Results: In both groups, most sites showed optimal healing with closure of the coronal entrance of the defects. However, residual defects occupied by soft tissues and biomaterial particles were observed, even though generally limited to some regions of the defect. Osseointegration of the implant surface in the region of the defect was poor in both groups. Conclusions: Circumferential marginal critical-size defects around implants filled with bovine xenografts presented regions with a complete healing in both groups. However, the healing was not complete at all regions in most defects; therefore, a complete optimal healing of critical-size marginal defects cannot be predicted.

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Section: Discussionmentioning

confidence: 99%

Critical-sized marginal defects around implants treated with xenografts in rabbits

Asano,

Xavier,

Silva

et al. 2023

Preprint

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show abstract

“…In another experimental study on rabbits [50], 2-to 3-mm-deep box defects of different dimensions (4, 5, 6, 8, and 10 mm) were prepared in the mandible. After 12 weeks of healing, the smallest defects were closed with newly formed bone.…”

Section: Discussionmentioning

confidence: 99%

Implants Placed with a Ring Technique Using Inlay and Onlay Block Xenografts in the Mandible of Rabbits

Kaneko,

Xavier,

Morinaga

et al. 2023

Materials

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Background: Xenogenous bone has been proposed as an alternative to overcome the disadvantages of autogenous grafting. The aim of the present study was to study bone dynamics at inlay and onlay xenografts used for bone augmentation applying a ring technique. Methods: The bone at the lateral surface of the mandibular angle of 12 adult male New Zealand White rabbits was exposed bilaterally. The cortical layer received multiple perforations on one side of the mandible, and a xenograft block of collagenated cancellous equine bone, 7 mm in diameter and 3 mm in width, was fixed on the prepared surface using an implant (onlay group). On the opposite side, a defect 7 mm in diameter and 3 mm in depth was prepared, and the xenograft block was adapted to the defect and fixed with an implant (inlay group). Results: After ten weeks of healing, in the onlay grafts, new bone was mainly formed on the trabeculae surface, reaching in some specimens the most coronal regions of the block. In the inlay grafts, new bone was found arranged on the trabecular surfaces but also occupying the spaces among the trabeculae. The entrance of the defect was often found close to the top of the block by newly formed bone. A higher percentage of new bone was found in the inlay (19.0 ± 9.3%) compared to the onlay (10.4 ± 7.4%) groups (p = 0.031). The mean gain in osseointegration at the implant in relation to the base of the original 3 mm deep defect was 0.95 ± 1.05% in the onlay group and 0.78 ± 0.71% in the inlay group (p = 0.603). Conclusion: The inlay grafts exhibited a higher new bone percentage than the onlay block grafts possibly due to the defect conformation that presented more sources for bone growth. The trabecular conformation and the composition of the grafts made possible the expression of the osteoconductive properties of the material used. This resulted, in several specimens, in the growth of bone on the graft trabeculae toward the most superior regions in both groups and in the closure of the coronal entrance of the defects in the inlay group. The clinical relevance of this experiment is that the ring technique applied as an inlay method could be suitable for bone augmentation.

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Critical-sized marginal defects around implants treated with xenografts in rabbits

Asano,

Xavier,

Silva

et al. 2024

Oral Maxillofac Surg

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Background: Healing of critical-size defects is a well-known problem that has been challenged in several studies. The aim of the experiment was to evaluate bone formation and osseointegration of implants installed in critical defects of the mandibular body simultaneously grafted with Bio-Oss® or Cerabone®.Material and methods: Defects, 10 mm wide and 3 mm deep, were prepared at both lateral aspects of the mandible in 12 rabbits. One implant was installed in the center of the defect, and bovine xenografts produced either at low (Bio-Oss®; Low-T) or high (Cerabone®; High-T) temperatures were used to ll the defects. A collagen membrane was placed to cover the sites. Healing was evaluated 10 weeks after surgery.Results: In both groups, most sites showed optimal healing with closure of the coronal entrance of the defects. However, residual defects occupied by soft tissues and biomaterial particles were observed, even though generally limited to some regions of the defect. Osseointegration of the implant surface in the region of the defect was poor in both groups.Conclusions: Circumferential marginal critical-size defects around implants lled with bovine xenografts presented regions with a complete healing in both groups. However, the healing was not complete at all regions in most defects; therefore, a complete optimal healing of critical-size marginal defects cannot be predicted.

show abstract

Determination of critical-sized defect of mandible in a rabbit model: Micro-computed tomography, and histological evaluation

Cited by 8 publications

References 39 publications

Critical-sized marginal defects around implants treated with xenografts in rabbits

Critical-sized marginal defects around implants treated with xenografts in rabbits

Implants Placed with a Ring Technique Using Inlay and Onlay Block Xenografts in the Mandible of Rabbits

Critical-sized marginal defects around implants treated with xenografts in rabbits

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