Determination of Dacarbazine Φ-Order Photokinetics, Quantum Yields, and Potential for Actinometry

Modeling and Elucidation of the Kinetics of Multiple Consecutive Photoreactions AB 4 (4Φ) With Φ-order Kinetics. Application to the Photodegradation of Riboflavin

“…does not yet provide a general and/or a unique fundamental explanation for the observed phenomenon. We have experimentally observed similar phenomenon for many drugs, 12,29,[35][36][37][38][39] that are corroborated by the findings reported in the literature.…”

“…Overall, such kinetic behaviour has previously been observed for several drugs. 12,29,[35][36][37][38] These findings might suggest a common trend for photodrugs and certainly confirm that the quantum yields must be experimentally defined before any conclusions on their wavelength-independence can be reached.…”

“…Overall, the quantum yield values for Ribo photodegradation were one order of magnitude smaller than those recorded for nifedipine, 12 nisoldipine, 38 montelukast 35 and fluvoxamine 29 , 10-and 100-fold lower than Dacarbazine 36 and Sunitinib, respectively. 37  Cal.…”

“…to determine the unknown, . A similar approach can be adopted for This methodology now offers a series of reliable actinometers that cover the UV and Visible (260 -570 nm) dynamic range including Fluvoxamine (260 -290 nm), 29 Dacarbazine (270 -350 nm), 36 Montelukast (260 -380 nm), 35 Axitinib (290 -380 nm), 39 Nifedipine (280 -400 nm), 12 Nisoldipine (320 -400 nm), 38 Sunitinib (320 -480 nm), 37 Riboflavin (420 -480 nm), and Diethylarene (405 -570 nm). 10 They also provide a wide range of photoreactivities as some are suitable for relatively fast reactions ( > 10 4 ) and others to relatively slow ones ( < 500).…”

Predicting wavelength-dependent photochemical reactivity and selectivity

“…Addressing such challenges requires an in-depth understanding of photokinetic behavior, i.e., the rationalization of how fast lightinduced reactions proceed under defined conditions and their associated dependence on experimental parameters. Attempts to predict photochemical kinetics have been reported, yet the resulting methods have not been widely utilized 15,16 . While there are-occasionally-reports of reaction quantum yields, even with their knowledge, the prediction of photochemical conversion is seldomly performed.…”