Determination of density of follicles on various regions of the face by cyanoacrylate biopsy: correlation with sebum output

Pagnoni, Alessandra; Kligman, Albert M.; Gammal, S. El; Stoudemayer, T.

doi:10.1111/j.1365-2133.1994.tb08590.x

Cited by 88 publications

(66 citation statements)

References 12 publications

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“…Such evaluations were made on CFB taken from symmetrical sites of the forehead at the baseline visit as well as after 2, 4 and 6 weeks of treatment. CFB was developed as an extension of skin surface stripping and refers to a non-invasive collection of stratum corneum and follicular material using cyanoacrylate adhesive [16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26]. The follicular casts so sampled from the upper portion of a follicular duct reflect the balance between comedo formation and lysis.…”

Section: Methodsmentioning

confidence: 99%

Split-Face Clinical and Bio-Instrumental Comparison of 0.1% Adapalene and 0.05% Tretinoin in Facial Acne

Piérard-Franchimont¹,

Henry²,

Fraiture³

et al. 1999

Dermatology

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Background: Adapalene and tretinoin are topical compounds active for treating acne. Objective: To compare the efficacity and safety of adapalene 0.1% gel and tretinoin 0.05% gel in moderately severe facial acne using clinical and objective biometrological assessments. Such information is currently lacking in the literature. Methods: The split-face method was used in 25 acne volunteers for a 6-week treatment. In addition to clinical counts of lesions, the amount of comedones was assessed using computer-assisted morphometry of cyanoacrylate follicular biopsies. The erythema index and squamometry values were used to quantitate skin irritation. Results: The tretinoin formulation brought better comedolysis and clinical improvement than the adapalene formulation. Erythema was transiently more pronounced on the tretinoin-treated side. Squamometry yielded no significant difference between both products. Conclusion: Tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, although with temperate tolerability.

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Section: Methodsmentioning

confidence: 99%

Split-Face Clinical and Bio-Instrumental Comparison of 0.1% Adapalene and 0.05% Tretinoin in Facial Acne

Piérard-Franchimont¹,

Henry²,

Fraiture³

et al. 1999

Dermatology

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“…The oily appearance commonly found on the ‘T’ zone (forehead, nose and chin) reflects the dominance of these sebaceous follicles. Pagnoni et al [19] found that sebum output and density of follicles followed a centrolateral decreasing gradient, and Lopez et al [20] showed that such a ‘T’-like distribution could indeed be clearly observed even in the women presenting the lowest mean value of sebum casual level 1 . We conclude that all skins are of a ‘combination’ type, with increased sebum values on the ‘T’ zone compared to the rest of the face, regardless if the skin is oily or not.…”

Section: Sebaceous Gland Anatomymentioning

confidence: 99%

Oily Skin: An Overview

Sakuma

Maibach²

2012

Skin Pharmacol Physiol

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Oily skin (seborrhea) is a common cosmetic problem that occurs when oversized sebaceous glands produce excessive amounts of sebum giving the appearance of shiny and greasy skin. This paper overviews the main concepts of sebaceous gland anatomy and physiology, including the biosynthesis, storage and release of sebum, as well as its relationship to skin hydration and water barrier function. We also address how skin oiliness may vary according to diet, age, gender, ethnicity and hot humid climates. The deeper understanding of this skin type provides the opportunity to better guide patients regarding skin care and also assist in the development of sebosuppressive agents.

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“…This represents a noninvasive method which combines the tape stripping technique [22] with cyanoacrylate skin surface biopsies [23,24] . Normally, for a cyanoacrylate skin surface biopsy, superglue is applied onto the skin surface and removed after polymerization together with an unknown amount of corneocytes and follicular casts [23] .…”

Section: Introductionmentioning

confidence: 99%

Semiquantitative Determination of the Penetration of a Fluorescent Hydrogel Formulation into the Hair Follicle with and without Follicular Closure by Microparticles by Means of Differential Stripping

Teichmann

Ossadnik

Richter

et al. 2006

Skin Pharmacol Physiol

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Recently, hair follicles were shown to be of great importance concerning the penetration and reservoir behavior of topically applied substances. Especially microparticles are known to be efficient drug carriers into the hair follicles. It has been shown in various investigations that, depending on their size, microparticles can be utilized to enhance the penetration of substances into the hair follicles. In the present study, it was investigated whether they could also be used to block the hair follicles to stop penetration. For this purpose, the follicular penetration of a sodium fluorescein-containing hydrogel and follicular reservoir depletion were investigated by means of differential stripping in vivo. In a second study design, the skin areas were pretreated with microparticles 5 µm in diameter. Subsequently, the follicular penetration of sodium fluorescein-containing hydrogel was likewise investigated by differential stripping. The results showed that the hair follicle infundibula contained a significant fluorescent signal when sodium fluorescein in hydrogel was applied. In contrast, in the case of pretreatment with microparticles, only a very low fluorescence signal was measurable in the hair follicle infundibula. The microparticles clearly blocked the follicular orifices so that a penetration of sodium fluorescein was almost completely inhibited. This was confirmed by histological investigations. Thus, depending on their size, microparticles act as efficient drug carriers or can be utilized as follicle blockers to stop the penetration of topically applied substances. This could be very useful in skin protection to prevent the storage of harmful topically applied substances in the hair follicles, known to represent long-term reservoirs.

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Determination of density of follicles on various regions of the face by cyanoacrylate biopsy: correlation with sebum output

Cited by 88 publications

References 12 publications

Split-Face Clinical and Bio-Instrumental Comparison of 0.1% Adapalene and 0.05% Tretinoin in Facial Acne

Split-Face Clinical and Bio-Instrumental Comparison of 0.1% Adapalene and 0.05% Tretinoin in Facial Acne

Oily Skin: An Overview

Semiquantitative Determination of the Penetration of a Fluorescent Hydrogel Formulation into the Hair Follicle with and without Follicular Closure by Microparticles by Means of Differential Stripping

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