Determination of diclofenac in plasma samples. Comparison between HRGC and HPLC

Giachetti, C; Poletti, P.; Zanolo, G.

doi:10.1002/jhrc.1240100813

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…Because of the broad clinical application of DIC, designing simple, quick, and sensitive technique for its determination seems to be necessary . Spectrophotometry , potentiometry , and chromatography can be mentioned as some of the conventional methods used for the quantitative determination of DIC.…”

Section: Introductionmentioning

confidence: 99%

“…Because of the broad clinical application of DIC, designing simple, quick, and sensitive technique for its determination seems to be necessary [3]. Spectrophotometry [4], potentiometry [5], and chromatography [6][7][8][9] can be Abbreviations: CPE, carbon paste electrode; DIC, diclofenac; FESEM, Field emission SEM; FFTSCV, fast Fourier transform stripping cyclic voltammetry; FSSLM, flat sheet liquid membrane; LR, linear range; PBS, phosphate-buffered solution; RGO, reduced graphene oxide; SLM, supported liquid membrane Conflict of interest: The authors declare no potential conflicts of interest.…”

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Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Mofidi

Norouzi

Sajadian

et al. 2018

J of Separation Science

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A novel, simple, and inexpensive analytical technique based on flat sheet supported liquid membrane microextraction coupled with fast Fourier transform stripping cyclic voltammetry on a reduced graphene oxide carbon paste electrode was used for the extraction and online determination of diclofenac in whole blood. First, diclofenac was extracted from blood samples using a polytetrafluoroethylene membrane impregnated with 1-octanol and then into an acceptor solution, subsequently it was oxidized on a carbon paste electrode modified with reduced graphene oxide nanosheets. The optimal values of the key parameters influencing the method were as follows: scan rate, 6 V/s; stripping potential, 200 mV; stripping time, 5 s; pH of the sample solution, 5; pH of the acceptor solution,7; and extraction time, 240 min. The calibration curves were plotted for the whole blood samples and the method was found to have a good linearity within the range of 1-25 μg/mL with a determination coefficient of 0.99. The limits of detection and quantification were 0.1 and 1.0 μg/mL, respectively. Using this coupled method, the extraction and determination were merged into one step. Accordingly, the speed of detection for sensitive determination of diclofenac in complex samples, such as blood, increased considerably.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Mofidi

Norouzi

Sajadian

et al. 2018

J of Separation Science

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The bioavailability of diclofenac from enteric coated products in healthy volunteers with normal and artificially decreased gastric acidity

Gelderen

Olling

Barends³

et al. 1994

Biopharm & Drug Disp

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The relative bioavailability of four monolithic enteric coated (MEC) diclofenac products was compared in 16 healthy volunteers. Only one generic product was fully bioequivalent with the reference product Voltaren with regard to AUC, Cmax, and tlag. Two products showed significant differences in tlag. In a second experiment with eight volunteers the influence of increased gastric pH (ranitidine treatment) on the two mutually most differing products was studied. They showed equivalence in AUC, but not in Cmax. Analysis of tlag suggests that the product with the low tlag disintegrates within the non-acid stomach, whereas the product with the long tlag passes the non-acid stomach intact. Several in vitro dissolution tests were conducted. The European Pharmacopeia test did not detect any differences between the products. At pH 5, both with and without mechanical stress, only the product with the shortest tlag released diclofenac. The in vivo results were best predicted by the in vitro dissolution tests performed at several fixed pH values with mechanical stress.

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High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

Giachetti¹,

Zanolo²,

Poletti³

et al. 1990

J. High Resol. Chromatogr.

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Determination of diclofenac in plasma samples. Comparison between HRGC and HPLC

Cited by 9 publications

References 5 publications

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

The bioavailability of diclofenac from enteric coated products in healthy volunteers with normal and artificially decreased gastric acidity

High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

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