Determination of Diethylstilbestrol in Aquatic Products by High Performance Liquid Chromatography with Fluorescence Detection

Xu, Yingjiang; Geng, Jinpei; Zhang, Xiuzhen; Zhang, Shijuan; Tian, Xin; Liu, Huihui

doi:10.1002/cjoc.201090040

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…The sampling volume was 100 mL, and the eluting solution was 2 mM NaOH, with a flow rate of 1.2 mL/min. The peroxide compounds were determined on the basis of fluorescent analysis by another HPLC instrument (Agilent 1100, USA) with post-column derivation, involving the oxidation of peroxides to a fluorescent derivative using hydroxyphenylacetic acid, through a reaction catalyzed by hemin [Xu and Chen, 2005]. The excitation wavelength was 315 nm, and the emission wavelength was 400 nm.…”

Section: Analysis Methodsmentioning

confidence: 99%

Heterogeneous reactions of methacrolein and methyl vinyl ketone: Kinetics and mechanisms of uptake and ozonolysis on silicon dioxide

Chen¹,

Jie²,

Li³

et al. 2008

J. Geophys. Res.

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[1] Methacrolein (MAC) and methyl vinyl ketone (MVK), two major first-generation products in the oxidation of isoprene, play important roles in tropospheric chemistry. However, little is known about their heterogeneous fate. Here we investigated the heterogeneous reactions of MAC and MVK on particles of silicon dioxide (SiO 2 ), the major constituent of mineral dust in the troposphere, under simulated tropospheric conditions. We first investigated the adsorption and desorption processes. It was found that MAC and MVK molecules were adsorbed onto the surface of SiO 2 particles by van der Waals forces and hydrogen bonding forces in a non-reactive state, and the presence of water vapor did not result in the formation of new substances but could decrease the adsorption ability by consuming isolated hydroxyl groups on the surface of SiO 2 particles. The initial adsorption and desorption rates, initial uptake coefficients, and adsorption concentrations at equilibrium were determined at different relative humidities. Notably, in the desorption process, a considerable amount of MAC or MVK molecules remained on SiO 2 particles in dry air but were almost completely desorbed in high-humid air. We also investigated the heterogeneous ozonolysis of MAC and MVK adsorbed onto SiO 2 particles, determining product yields at different relative humidities. The heterogeneous ozonolysis of MAC and MVK adsorbed onto SiO 2 particles yielded formaldehyde and methylglyoxal as the major secondary carbonyl products and formic acid and acetic acid as the major organic acid products, as in their gas-phase ozonolysis. However, the yield of two major organic peroxides, methyl hydroperoxide and hydroxymethyl hydroperoxide, was much greater in their heterogeneous ozonolysis than in their gas-phase ozonolysis. The mechanisms of heterogeneous ozonolysis of MAC and MVK onto the SiO 2 surface are deduced.

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Section: Analysis Methodsmentioning

confidence: 99%

Heterogeneous reactions of methacrolein and methyl vinyl ketone: Kinetics and mechanisms of uptake and ozonolysis on silicon dioxide

Chen¹,

Jie²,

Li³

et al. 2008

J. Geophys. Res.

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“…So far, many detection methods have been established for DES analysis, such as high-performance liquid chromatography (HPLC), 6 gas chromatography−mass spectrometry (GC-MS), 7 enzyme-linked immunoassay, 8,9 and others. 10,11 By contrast, biosensing methods have the advantages of high sensitivity, high selectivity, and relatively low cost.…”

Section: Introductionmentioning

confidence: 99%

“…So far, many detection methods have been established for DES analysis, such as high-performance liquid chromatography (HPLC), gas chromatography–mass spectrometry (GC-MS), enzyme-linked immunoassay, , and others. , By contrast, biosensing methods have the advantages of high sensitivity, high selectivity, and relatively low cost. To date, fluorescent biosensing methods based on various fluorescent materials have been developed for the detection of DES. , For instance, Chen’s group successfully synthesized aptamer-modified upconversion nanoparticles (UCNPs) for the fluorescence quenching detection of DES with good practicability in real environments and food samples .…”

Section: Introductionmentioning

confidence: 99%

Construction of Aptamer-Molecularly-Imprinted Fluorescent Covalent Organic Framework and Its Collaborative Recognition of Diethylstilbestrol

Zhao,

Lin,

et al. 2023

ACS Food Sci. Technol.

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As a synthetic estrogen substance, diethylstilbestrol (DES) is often used in the aquaculture industry and easily enters the human body and causes health threats. Herein, a biosensing method based on fluorescent covalent organic frameworks (COFs) with aptamers and molecularly imprinted polymers (MIPs) was constructed. TP-COF with stable fluorescence emission was used as a fluorescence signal, coupled with DES aptamer, and further coated with MIPs. The obtained aptamer-molecularly imprinted COFs (COFs-Apt@MIPs) could recognize DES through the cooperation of aptamers and MIPs and induce fluorescence quenching. Dual recognition elements not only significantly improved affinity and specificity but also reduced the interference from complex matrix environments. The sensor exhibited a low detection limit (0.23 mg/L) and a good linear range (0.4−25.6 mg/L) for DES. It was further applied to detect fish samples with a recovery of 98.68%−101.97%, indicating its prospect of application in the detection of various fish drug residues.

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Validated Method for the Simultaneous Determination of Lisinopril, Pravastatin, Atorvastatin and Rosuvastatin in API, Formulations and Human Serum by RP-HPLC

Sultana¹,

Arayne²,

Sattar

2011

Chin. J. Chem.

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Lisinopril is found to be useful in hypertension and statins as cholesterol lowering drug. Present work was designed for the simultaneous determination of lisinopril in presence of pravastatin, atorvastatin, and rosuvastatin using RP-HPLC method. A Purospher star C18 (5 µm, 25×0.46 cm) column was used with mobile phase consisting of acetonitrile∶water (60∶40 V/V, pH 3.0) with flow rate of 1.0 mL•min -1 and the quantitative evaluation was performed at 225 nm. The retention time of lisinopril was 2.0 min and for pravastatin, rosuvastatin and atorvastatin was found to be 3.1, 4.5 and 8.3 min respectively. Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with the requirements laid down by International Conference on Harmonization (ICH) guidelines. Application of the suggested procedures were successfully applied to the determination of these compounds in active pharmaceutical ingredient and in pharmaceutical preparations, with high percentage of recovery, good accuracy and precision.

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Determination of Diethylstilbestrol in Aquatic Products by High Performance Liquid Chromatography with Fluorescence Detection

Cited by 12 publications

References 24 publications

Heterogeneous reactions of methacrolein and methyl vinyl ketone: Kinetics and mechanisms of uptake and ozonolysis on silicon dioxide

Heterogeneous reactions of methacrolein and methyl vinyl ketone: Kinetics and mechanisms of uptake and ozonolysis on silicon dioxide

Construction of Aptamer-Molecularly-Imprinted Fluorescent Covalent Organic Framework and Its Collaborative Recognition of Diethylstilbestrol

Validated Method for the Simultaneous Determination of Lisinopril, Pravastatin, Atorvastatin and Rosuvastatin in API, Formulations and Human Serum by RP-HPLC

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