Determination of dimethylamine in biological samples by high-performance liquid chromatography

Teerlink, Tom; Hennekes, M.; Mulder, Cees; Brulez, Harald F.H.

doi:10.1016/s0378-4347(96)00476-8

Cited by 35 publications

(32 citation statements)

References 28 publications

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“…in the range 14.4-49.8 M [5]. DMA serum concentrations of this order of magnitude in healthy subjects and in haemodialysis patients were also reported by Baba et al [17].…”

Section: Derivatization/extraction Procedures and Concentration Of Thesupporting

confidence: 79%

“…In serum of healthy humans, DMA concentration was measured by Teerlink et al [5] to range 1.0-5.5 M, whereas in dialysis patients DMA concentration were much higher, i.e. in the range 14.4-49.8 M [5].…”

Section: Derivatization/extraction Procedures and Concentration Of Thementioning

confidence: 97%

“…Because urine and plasma or serum greatly differ with respect to experimentally relevant parameters such as pH, buffer capacity, protein and DMA concentration [5], and emulsion formation susceptibility, the derivatization/extraction procedure was thoroughly investigated and optimized for plasma samples.…”

Section: Procedures For Plasma and Serum Collection And Sample Derivamentioning

confidence: 99%

“…Dimethylamine [DMA, (CH 3 ) 2 NH)] is the most abundant short-chain aliphatic amine present in human urine and blood [1][2][3][4][5][6]. DMA is also present in other biological fluids including saliva, gastric juice and vaginal secretions [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The relative contribution of exogenous and endogenous sources to DMA and the pathophysiological significance of DMA are currently two challenging tasks [11]. Reported analytical methods for the measurement of DMA in human body fluids include colorimetric assays [6], head-space GC [2], HPLC with fluorescence detection [5], and GC-MS [1]. Ripley et al described a GC method with N-P detection for the analysis of DMA and other primary and secondary amines in foodstuffs by using a benzene solution of pentafluorobenzoyl chloride (PFBoylCl) to prepare the pentafluorobenzamide derivatives [14].…”

Section: Introductionmentioning

confidence: 99%

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Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC–MS and GC–tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode

Chobanyan¹,

Mitschke²,

Gutzki³

et al. 2007

Journal of Chromatography B

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“…in the range 14.4-49.8 M [5]. DMA serum concentrations of this order of magnitude in healthy subjects and in haemodialysis patients were also reported by Baba et al [17].…”

Section: Derivatization/extraction Procedures and Concentration Of Thesupporting

confidence: 79%

Section: Derivatization/extraction Procedures and Concentration Of Thementioning

confidence: 97%

Section: Procedures For Plasma and Serum Collection And Sample Derivamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC–MS and GC–tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode

Chobanyan¹,

Mitschke²,

Gutzki³

et al. 2007

Journal of Chromatography B

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A novel gaseous dimethylamine sensor utilizing cataluminescence on zirconia nanoparticles

Cao¹,

Liu²,

Zuo³

et al. 2009

Luminescence

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A novel cataluminescence (CTL) sensor using ZrO2 nanoparticles as the sensing material was developed for the determination of trace dimethylamine in air samples based on the catalytic chemiluminescence (CL) of dimethylamine on the surface of ZrO2 nanoparticles. The CTL characteristics and the different factors on the signal intensity for the sensor, including nanomaterials, working temperature, wavelength and airflow rate, were investigated in detail. The CL intensity on ZrO2 nanoparticles was the strongest among the seven examined catalysts. This novel CL sensor showed high sensitivity and selectivity to gaseous dimethylamine at optimal temperature of 330 degrees C. Quantitative analysis was performed at a wavelength of 620 nm. The linear range of CTL intensity vs concentration of gaseous dimethylamine was 4.71 x 10(-3) to 7.07 x 10(-2 )mg L(-1) (r = 0.9928) with a detection limit (3sigma) of 6.47 x 10(-4) mg L(-1). No or only very low levels of interference were observed while the foreign substances such as benzene, hydrochloric acid, methylbenzene, chloroform, n-hexane and water vapor were passing through the sensor. The response time of the sensor was less than 50 s, and the sensor had a long lifetime of more than 60 h. The sensor was successfully applied to the determination of dimethylamine in artificial air samples, and could potentially be applied to analysis of nerve agents such as Tabun (GA).

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Novel Flow‐through Potentiometric System for Dimethyamine Assessment Using New Ion Exchangers Doped‐polymeric Membrane Sensors

2018

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New simple potentiometric sensing systems are described for the sensitive and selective monitoring of dimethylamine (DMA). These systems are based on using polymeric membranes doped in some ion exchangers such as dimethylamine/phosphomolybdate [(CH3)2NH3]22+[MP]2− (Sensor I), dimethylamine/tetraphenylborate [(CH3)2NH3]+[TPB]− (Sensor II) and dimethylamine/phosphotungstate [(CH3)2NH3]+[TP]− (sensor III). All the sensing systems are incorporated in poly(vinyl chloride) matrix plasticized with o‐NPOE. In a Trizma buffer solution of pH 7.1, the sensors exhibit a stable, fast and linear response for 5.0×10−6–1.0×10−2, 2.5×10−5–1.0×10−2, and 5.0×10−6–1.0×10−2 mol L−1 DMA+ with slopes of 53.2±0.4, 49.4±0.6, and 53.8±0.3 mV decade−1, and detection limits of 2.0×10−6 (0.16 μg mL−1), 1.6×10−5(1.3 μg mL−1), and 1.4×10−6 (0.11 μg mL−1) mol L−1 for sensors (I), (II), and (III), respectively. Potentiometric selectivity measurements of these sensors reveal negligible interferences from most common aliphatic and aromatic amines. Satisfactory results are obtained with an average accuracy of 99.5 % and a mean precision of ±0.5 %. Validation of the proposed assay methods are examined by measuring the limit of detection, linearity range, accuracy, precision, within‐day repeatability, between‐days reproducibility and method ruggedness. Good performance characteristics and applicability of these sensors for DMA assessment in different matrices under static and hydrodynamic modes of measurements are demonstrated. The proposed sensors are also prepared in a tubular form and used as DMA detector in a two‐channel flow injection setup for continuous monitoring. The frequency rate is 27–53 samples h−1. The sensors are satisfactory applied for DMA quantification in both biological matrices and environmental samples with recoveries ranging between 95.0 and 104.0 %.

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Determination of dimethylamine in biological samples by high-performance liquid chromatography

Cited by 35 publications

References 28 publications

Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC–MS and GC–tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode

Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC–MS and GC–tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode

A novel gaseous dimethylamine sensor utilizing cataluminescence on zirconia nanoparticles

Novel Flow‐through Potentiometric System for Dimethyamine Assessment Using New Ion Exchangers Doped‐polymeric Membrane Sensors

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