Determination of Dinotefuran and Its Metabolites in Orange Pulp, Orange Peel, and Whole Orange Using Liquid Chromatography-Tandem Mass Spectrometry

Yang, Zaihui; Zhang, Kankan; Chen, Lingzhu; Liu, Bin; Zhang, Qingtao; Zhang, Haizhen; Sun, Caiyuan; Hu, Deyu

doi:10.5740/jaoacint.16-0424

Cited by 9 publications

(7 citation statements)

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“…Before photolysis (black traces), DNF (MW 202) shows a parent peak at m/z 203 corresponding to [DNF + H] + as well as a dimer ion at m/z 405 corresponding to [2DNF + H] + (data not shown). MS/MS analysis of m/z 203 (Figure S5) showed fragments at m/z 157, 129, and 113, consistent with the literature for DNF. − …”

Section: Resultssupporting

confidence: 86%

“…After photolysis (Figure , colored traces), product peaks corresponding to urea (UR DNF ) and desnitro (DN DNF ) derivatives appear, which are commonly observed for samples containing DNF and its metabolites. ,,, UR DNF (MW 158) is seen at m/z 159 corresponding to [UR DNF + H] + as well as at m/z 317 and m/z 361 (data not shown) corresponding to [2UR DNF + H] + and [UR DNF + DNF + H] + , respectively. The peak at m/z 158 corresponds to [DN DNF + H] + for the desnitro derivative DN DNF (MW 157).…”

Section: Resultsmentioning

confidence: 96%

“…55−59 After photolysis (Figure 5, colored traces), product peaks corresponding to urea (UR DNF ) and desnitro (DN DNF ) derivatives appear, which are commonly observed for samples containing DNF and its metabolites. 55,57,58,60 S6, and a fragmentation mechanism consistent with the major fragments is provided in Scheme S1. Peaks were also observed at m/z 156 and m/z 172 before and after photolysis.…”

Section: Resultsmentioning

confidence: 99%

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Probing Matrix Effects on the Heterogeneous Photochemistry of Neonicotinoid Pesticides, Dinotefuran and Nitenpyram

Rohrbacher

Ezell

Perraud

et al. 2021

ACS Earth Space Chem.

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The environmental fate of neonicotinoids (NNs) is a key regulatory issue due to their widespread distribution, mobility, and role in honeybee colony collapse disorder. Here, we explore the potential matrix effects of the commercial formulations on the photochemistry of two NNs, dinotefuran (DNF) and nitenpyram (NPM). The commercial formulations and the pure reagents, both embedded in KBr pellets, were irradiated at wavelengths from 254 to 350 nm. Loss of the NN and product formation were followed using Fourier transform infrared spectroscopy and direct analysis in real time mass spectrometry. Quantum yields for loss of NN in commercial formulations were within experimental error of the pure NN. However, quantum yields for loss in KBr were consistently smaller than those previously measured for thin films of pure compounds, suggesting increased quenching of excited intermediates in the dense solid KBr matrix. At 350 nm where NPM absorbs, the quantum yield for loss in the formulation was about half that of the pure compound, which was attributed to a reduction in the NPM absorption cross section due to the presence of water taken up by additional formulation ingredients. Major products of DNF and NPM photolysis were the same in the formulation and in the pure compound. However, in contrast to previous thin film measurements, unexpected infrared peaks at 2222 and 2136 cm −1 during photolysis of DNF in KBr were identified as N 2 O trapped in the KBr matrix and NO + , respectively. Overall, the presence of other compounds in the formulations did not significantly alter the photochemistry compared to the pure compounds.

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

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Probing Matrix Effects on the Heterogeneous Photochemistry of Neonicotinoid Pesticides, Dinotefuran and Nitenpyram

Rohrbacher

Ezell

Perraud

et al. 2021

ACS Earth Space Chem.

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“…Several types of research had been reported that QuEChERS or solid-phase extraction technology combined with gas chromatography-mass spectrometry (GC-MS), gas chromatography-nitrogen phosphorus detector (GC-NPD), gas chromatography-electron capture detector (GC-ECD), high-performance liquid chromatography-diode array detection (HPLC-DAD), high-performance liquid chromatography-ultraviolet detector (HPLC-UVD), ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and ultra-high-performance liquid chromatography coupled to Orbitrap mass spectrometry (UHPLC-Orbitrap-MS) could achieve the analysis of flonicamid, dinotefuran and its metabolites, separately. 5,9,10,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] In particular, the residual analysis and chronic dietary risk assessment of flonicamid on green tea, cabbage, cucumber, apple, potato, honeysuckle, cotton and paprika, 5,9,10,18-24 dinotefuran and its metabolites on cucumber, cotton, apple, Oryza sativa, eggplant, plum, orange, green tea, and melon 16,[25][26][27][28][29][30][31][32] have been carried out. However, to the best of our knowledge, studies on the degradation patterns and final residue levels of this mixture preparation on peach trees were still scarce so far, which were of great significance for the evaluation of its potential dietary intake hazards to consumers and for guaranteeing food safety.…”

Section: Introductionmentioning

confidence: 99%

Residual behavior and dietary intake risk assessment of flonicamid, dinotefuran and its metabolites on peach trees

Xu¹,

Du²,

Xu³

et al. 2021

J Sci Food Agric

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BACKGROUND: Flonicamid and dinotefuran are widely applied to control pests and diseases in various economic crops arousing much public concerns about the potential risk to human health. In this study, the multi-determination and residual behavior of flonicamid-dinotefuran mixture on peach trees were investigated. The chronic risk of long-term dietary intake for Chinese consumers was evaluated.RESULTS: An optimized QuEChERS method combined with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis for simultaneous determination of flonicamid, dinotefuran and its metabolites was established to analyze the residual dissipation and terminal residues in peach matrices. The results demonstrated that (i) a satisfactory linearity relationship with the detector response and the correlation coefficient R 2 > 0.999, the average recoveries of these four analytes ranged from 94 to 108%, the relative standard deviation was between 1.0% and 8.8%, and the limit of the quantitation was 0.02 mg kg −1 ; (ii) the dissipation behaviors of flonicamid and dinotefuran followed with the first-order dynamic kinetics model, and the half-lives were 6.9-12.4 days and 8.1-15.1 days, respectively; (iii) the recommended preharvest interval (PHI) was 21 days, the risk quotient (RQ) values of flonicamid and dinotefuran were 16.6 and 20.7%, respectively, which were significantly less than 100%.CONCLUSION: The established analytical method met the detection requirement in terms of sensitivity, accuracy, and precision. Additionally, the results indicated that the potential dietary intake risk of the flonicamid-dinotefuran mixture on peach trees was negligible. This work can be utilized in the safe and responsible use of flonicamid-dinotefuran mixture and provide guidance for establishing its maximum residue limit (MRL) in China.

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“…Furthermore, these references selected only three or fewer sites to conduct field trials, and the samples collected from field sites were not adequately representative. Various studies have reported residue analysis of DIN, UF and DN in eggplant (Chen, Liu, et al, 2018), apples (Yu et al, 2017), rice (Li et al, 2017), wolfberry (W. Li, Shen, et al, 2019), orange (Yang et al, 2017), peach (Xu et al, 2021), cucumber (X. Chen, Dong, Xu, et al, 2015) and plum (Rahman et al, 2018) with methods such as (QuEChERS) coupled with HPLC–MS/MS or HPLC. However, very few papers have reported the residual analysis of DIN and its two metabolites in wheat.…”

Section: Introductionmentioning

confidence: 99%

Residual levels and dietary risk assessment of bifenthrin and dinotefuran and its major metabolites in open wheat field conditions

2021

Biomedical Chromatography

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To evaluate the residual levels of bifenthrin and dinotefuran, a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) and high‐performance liquid chromatography–tandem mass spectrometry method for simultaneous detection of bifenthrin and dinotefuran and its major metabolites in wheat was developed and validated. Dietary risk assessments were further performed based on the relevant residual data from 12 wheat fields, toxicology data and dietary patterns. In wheat grain and straw, the recoveries of all analytes ranged from 77 to 102% with the relative standard deviation <9.7% and the limit of quantitation 0.05 mg kg−1. The highest terminal residue of bifenthrin in wheat grain was 0.069 mg kg−1 and dinotefuran was 0.34 mg kg−1. Residual concentrations of bifenthrin and dinotefuran decreased to <0.05 and 0.15 mg kg−1 at 21 days (pre‐harvest interval), respectively. The chronic risk quotient ranged from 6.4 to 62.7% and the acute risk quotient varied from 0.38 to 17.73%. The chronic and acute dietary risks caused by the terminal residues of the two insecticides were negligible for Chinese populations. The recommended pre‐harvest interval was proposed to ensure safe wheat consumption. These data could provide a scientific reference to establish the Chinese maximum residue limit of dinotefuran in wheat.

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Determination of Dinotefuran and Its Metabolites in Orange Pulp, Orange Peel, and Whole Orange Using Liquid Chromatography-Tandem Mass Spectrometry

Cited by 9 publications

References 0 publications

Probing Matrix Effects on the Heterogeneous Photochemistry of Neonicotinoid Pesticides, Dinotefuran and Nitenpyram

Probing Matrix Effects on the Heterogeneous Photochemistry of Neonicotinoid Pesticides, Dinotefuran and Nitenpyram

Residual behavior and dietary intake risk assessment of flonicamid, dinotefuran and its metabolites on peach trees

Residual levels and dietary risk assessment of bifenthrin and dinotefuran and its major metabolites in open wheat field conditions

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