Determination of doxycycline in pharmaceuticals based on its degradation by Cu(II)/H2O2 reagent in aqueous solution

Sunarić, Slavica; Mitić, Snežana S.; Miletić, G. Ž.; Pavlović, Aleksandra; Naskovic-Djokic, D.

doi:10.1134/s1061934809030046

Cited by 35 publications

(21 citation statements)

References 14 publications

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“…The experimental results are consistent with the literature data [4,6], which suggest that the presence of metals adsorbed on activated carbon, ie both Fe(II) and Cu(II), causes an increase in the efficiency of decomposition of H 2 O 2 and contributes to the generation of hydroxyl radicals as well as an increase in the concentration of acidic oxygen groups on the sorbent surface. The analysis shows that it was due to the relatively high sorptive capacity of the regenerated activated carbons with respect to metal ions.…”

Section: Discussion Of Resultssupporting

confidence: 81%

“…Today, more and more attention is being paid to the application of oxidation reaction, for instance Fenton's reaction, (Fe 2+ /H 2 O 2 ), to remove organic pollutants from industrial waste [1][2][3]. In Fenton's reaction, the oxidizing agent is the generated hydroxyl radicals, and the procedure is classified to be an Advanced Oxidation Process (AOP) [1][2][3][4][5][6][7][8]. Oxidizing organic substances in aqueous solutions requires using large amounts of reagents and energy and disposing of wastewater containing oxidation by-products.…”

mentioning

confidence: 99%

“…Oxidizing organic substances in aqueous solutions requires using large amounts of reagents and energy and disposing of wastewater containing oxidation by-products. A possible solution to the problem is to combine the processes of oxidation and sorption of organic compounds on activated carbon [1][2][3][4][5][6][7][8]. The sorbent introduced into the reaction system enables not only sorption of the pollutants present in the solution but also oxidation of by-products.…”

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confidence: 99%

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Assessing the Influence of the Presence of Heavy Metals Adsorbed on Activated Carbon on the Efficiency of Degradation of Phenol Using Selected Oxidizing Agents

Dąbek

Ozimina

Picheta-Oleś

2012

Ecological Chemistry and Engineering S

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Removing organic substances from wastewater is a complex problem. Different methods are used for this purpose. Recently, much attention has been given to the application of sorption and advanced oxidation processes (AOPs), which contribute also to the regeneration of activated carbon. The analysis presented in this paper focused on determining the influence of Cu(II) and Fe(II) ions adsorbed on activated carbon on the efficiency of oxidation of phenol by means of H2O2, Fenton's reagent Fe 2+ /H2O2 and 1:1 HNO3 solution exposed to 2450 MHz microwaves, and, accordingly, the influence of Cu(II) and Fe(II) ions on the sorptive capacity of regenerated activated carbons. The results show that the chemical regeneration of activated carbon using AOPs resulted in partial oxidation of the adsorbed organic substance. The presence of Cu(II) or Fe(II) ions increased the regeneration efficiency. Using nitric acid to oxidize adsorbed phenol brought about a dramatic decline in the sorptive capacity of activated carbon with respect to this substance and an increase in the sorptive capacity of carbon with respect to metal ions. A serious drawback of this method, however, is that the oxidation of adsorbed phenol caused a significant loss of mass of activated carbon regardless of the oxidizing agent used.

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Section: Discussion Of Resultssupporting

confidence: 81%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Assessing the Influence of the Presence of Heavy Metals Adsorbed on Activated Carbon on the Efficiency of Degradation of Phenol Using Selected Oxidizing Agents

Dąbek

Ozimina

Picheta-Oleś

2012

Ecological Chemistry and Engineering S

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“…Although these procedures are specific, most of the described methods are time consuming and require multistage extraction procedures. On the other hand, the reported spectrophotometric methods (5)(6)(7)(8)(9)(10) are for different reasons not satisfactory for the routine quality assurance. Some of these methods suffer from disadvantages such as poor sensitivity, low stability of the species, use of organic solvent, scrupulous control of experimental variables and special equipment (Table VII).…”

mentioning

confidence: 99%

“…These include FIA-spectrophotometry with copper carbonate (5) and spectrophotometry based on colour reactions with thorium(IV) (6), sodium cobaltnitrite (7) and uranyl acetate (8). Besides, kinetic spectrophotometry using Cu(II)/H 2 O 2 (9) and multivariate calibration method (10) have also been reported by different authors.…”

mentioning

confidence: 99%

Sensitive and selective spectrophotometric assay of doxycycline hyclate in pharmaceuticals using Folin-Ciocalteu reagent

Ramesh¹,

Basavaiah²,

Rajendraprasad³

2010

Acta Pharmaceutica

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Doxycycline hyclate (DOX), chemically known as (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride hemiethanol hemihydrate (Fig. 1), is one of the tetracycline derivatives, which has a wide range of antibacterial activities. DOX is frequently used to treat chronic prostatitis, sinusitis, syphilis, chlamydia, pelvic inflammatory disease, acne, rosacea, and rickettsial infections.The drug is official in British Pharmacopoeia (1), which describes the HPLC method for the determination of DOX either in raw material or in pharmaceutical formulations. A spectrophotometric method for the determination of doxycycline (DOX) is described. The method is based on the formation of blue colored chromogen due to reduction of tungstate and/or molybdate in Folin-Ciocalteu (F-C) reagent by DOX in alkaline medium. The colored species has an absorption maximum at 770 nm and the system obeys Beer's law over the concentration range 0.75-12.0 mg mL -1 DOX. The apparent molar absorptivity is 2.78´10 4 L mol -1 cm -1 . The limit of quantification and detection values are reported to be 0.20 and 0.08 mg mL -1 , respectively. Over the linear range applicable, the accuracy and precision of the method were evaluated on intra-day and inter-day basis. The reported mean accuracy value was 101.0 ± 1.7 %, the relative error was £ 2.7 % and the relative standard deviation was £ 2.5 %. Application of the proposed method to bulk powder and commercial pharmaceutical tablets is also presented. No significant difference was obtained between the results of the proposed method and the official BP method. The procedure described in this paper is simple, rapid, accurate and precise.

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Effective degradation of doxycycline by photocatalytic BiVO₄–H₂O₂ under visible light

Tong

Kang

Shen

et al. 2019

Env Prog and Sustain Energy

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Doxycycline (DOX) is a type of antibiotic that exists in the environment and is desired to be effectively removed. Herein, DOX was degraded by photocatalytic BiVO4–H2O2 and photocatalytic BiVO4 systems in this paper. Under the same degradation conditions, the effects of the two systems on DOX degradation were compared. The effect of the solution pH on degradation of DOX was examined in the range of 3.5–11.5. The optimum pH values were 7.5 and 11.5 for light‐BiVO4–H2O2 and light‐BiVO4 systems, respectively, and their removal rates were 96.27 and 98.84%, respectively. The optimum temperature of degradation was both 40°C by two methods, and the removal rates were 97.03 and 53.43%, respectively. The optimum dosage of BiVO4 was both 70 mg by two methods, and the removal rates were 95.92 and 52.52%, respectively. The degradation effect by light‐BiVO4–H2O2 method was better than that by light‐BiVO4 method. The possible photocatalytic reaction mechanism was also discussed briefly based on ESR spectrum. DMPO trapping experiment was applied to reveal the production of hydroxyl radicals. These works provide promising constructs at dealing with the DOX water by photocatalytic degradation.

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Determination of doxycycline in pharmaceuticals based on its degradation by Cu(II)/H2O2 reagent in aqueous solution

Cited by 35 publications

References 14 publications

Assessing the Influence of the Presence of Heavy Metals Adsorbed on Activated Carbon on the Efficiency of Degradation of Phenol Using Selected Oxidizing Agents

Assessing the Influence of the Presence of Heavy Metals Adsorbed on Activated Carbon on the Efficiency of Degradation of Phenol Using Selected Oxidizing Agents

Sensitive and selective spectrophotometric assay of doxycycline hyclate in pharmaceuticals using Folin-Ciocalteu reagent

Effective degradation of doxycycline by photocatalytic BiVO₄–H₂O₂ under visible light

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Determination of doxycycline in pharmaceuticals based on its degradation by Cu(II)/H2O2 reagent in aqueous solution

Cited by 35 publications

References 14 publications

Assessing the Influence of the Presence of Heavy Metals Adsorbed on Activated Carbon on the Efficiency of Degradation of Phenol Using Selected Oxidizing Agents

Assessing the Influence of the Presence of Heavy Metals Adsorbed on Activated Carbon on the Efficiency of Degradation of Phenol Using Selected Oxidizing Agents

Sensitive and selective spectrophotometric assay of doxycycline hyclate in pharmaceuticals using Folin-Ciocalteu reagent

Effective degradation of doxycycline by photocatalytic BiVO4–H2O2 under visible light

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Effective degradation of doxycycline by photocatalytic BiVO₄–H₂O₂ under visible light