Determination of Epinephrine in Pharmaceutical Formulation by an Optimized Novel Luminescence Method Using CdS Quantum Dots as Sensitizer

Abstract

In this article, a novel chemiluminescence method using water-soluble CdS quantum dots (QDs) as sensitizers is proposed for the chemiluminometric determination of epinephrine. The method is based on the quenching effect of epinephrine on the chemiluminescence emission generated by the mixing of CdS quantum dots (QDs) with hydrogen carbonate (HCO3(-)) in the presence of hydrogen peroxide (H2O2) in an alkaline medium. The optimization of variables influencing the chemiluminescence response of the method has been carried out by using experimental design. Under the optimal conditions, there is good linear relationship between the relative chemiluminescence intensity and the concentration of epinephrine over the range of 5 × 10(-9)-1 × 10(-6) molL(-1) with a 3σ detection limit of 5 × 10(-11) molL(-1). The method has been successfully applied to the determination of epinephrine in pharmaceutical formulation and the recovery test was done in human urine.

Sensitive Determination of Cetirizine Using CdS Quantum dots as Oxidase Mimic-mediated Chemiluminescence of Sulfite

“…Although the wavelength of our spectrometer is omitted by the light source, the absorption band of the CdS nanoparticles shows a blue shift due to the quantum confinement of the excitations present in the sample as compared with the bulk CdS particles. This optical phenomenon shows that these nanoparticles have a quantum size effect ) Azizi et al, 2013;Berger, 1996(. In addition, Fourier transform infrared spectroscopy was carried out in order to confirm the bonding of thioglycolic acid (TGA) to the nanoparticle surface.…”

Rescue of cortical neurovascular functions during the hyperacute phase of ischemia by peripheral sensory stimulation

“…The timely redistribution of blood into the ischemic penumbra (salvageable tissue surrounding the ischemic core) could markedly improve the outcome (Lo, 2008;Muir et al, 2006). Currently, the most well-known therapeutic agent for stroke recovery is recombinant tissue plasminogen activator (rtPA) (Azizi et al, 2013), which breaks down clots, resulting in the reintroduction of blood into the ischemic brain region (i.e., reperfusion). Unfortunately, rtPA is viable for only a small portion (approximately 3.6%) of stroke patients (Go et al, 2013) and may cause tissue damage by weakening the blood vessel walls or disrupting the blood-brain barrier (BBB) (Abu Fanne et al, 2010).…”

Chemiluminescence of Mn-Doped ZnS Nanocrystals Induced by Direct Chemical Oxidation and Ionic Liquid-Sensitized Effect as an Efficient and Green Catalyst

“…2 Journal of Spectroscopy Chen et al and Frigerio et al discussed the mechanism of QDs in CL reactions and summarize the applications of QDsbased CRET in detection of small biological molecules, DNA and protein analysis, cell imaging, and immunoassays [13,14]. Our group also reported the effect of CdS QDs on the CL of hydrogen peroxide-sodium hydrogen carbonate system [15].…”