Determination of Ethylene Oxide, Ethylene Chlorohydrin, and Ethylene Glycol by Gas Chromatography

Gas chromatographic determination of residual ethylene oxide by head space analysis

“…The DMF solvent extraction method was developed as an independent sample work-up procedure, so that a direct comparison could be made between samples. Also, since solvent extraction is used as a health industry standard method, it afforded a comparison of methods (13). Figures 3 and 4 show chromatograms obtained for the head space and DMF methods, respectively.…”

Comparison of Analytical Methods for Residual Ethylene Oxide Analysis

“…Since many sterilized items are used in such a way that they contact sensitive human tissue, the residual ethylene oxide should be at a safe level since ethylene oxide is in itself toxic. EXPERIMENTAL Methods-Four methods of analysis were studied a gravimetric method (3) and three GC approaches (9)(10)(11)(12). Late in 1972, an ad hoc committee was formed within 279 made up of industrial, regulatory, and academic representatives.…”

Ethylene Chlorohydrin Determination in Ethylene Oxide Sterilized Polyvinyl Chloride Tubing

“…Sterilization with ethylene oxide is actually the most used method for heat-sensitive materials such as plastic medical devices. In the last decade research has mainly been carried out on the toxicity of ethylene oxide (1) and its presence in sterilized synthetic polymers (2)(3)(4)(5). Work was also carried out on the reactivity of ethylene oxide and the reaction products present within sterilized materials (6).…”