Determination of exhaled nitric oxide distributions in a diverse sample population using tunable diode laser absorption spectroscopy

Namjou, Khosrow; Roller, Chad; Reich, Tobias; Jeffers, James D.; McMillen, Gina; McCann, P.J.; Camp, Mark A.

doi:10.1007/s00340-006-2301-3

Cited by 61 publications

(31 citation statements)

References 18 publications

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“…Currently there are two commercial laser-based instruments for the determination of exhaled NO, using a lead salt laser [31] and a QCL [10], respectively. The WMSbased sensor described in Sect.…”

Section: No Detection From Human Breathmentioning

confidence: 99%

Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives

et al. 2012

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Optical methods based on quantum cascade lasers (QCLs) are becoming popular in many life science applications. We report on two trace gas detection schemes based on continuous wave QCLs for on-line detection of nitric oxide (NO) at the sub-part-per-billion level by volume (ppbv, 1 : 10 −9 ), using wavelength modulation spectroscopy (WMS) and Faraday rotation spectroscopy (FRS) at 1894 cm −1 and 1875.73 cm −1 , respectively. Several technical incremental steps are discussed to further improve the sensitivity of these methods. Examples are included to demonstrate the merits of WMS-based sensor: direct monitoring of NO concentrations in exhaled breath, and from plants under pathogen attack. A simple hand-held breath sampling device that allows single breath collection at various exhalation flows (15, 50, 100 and 300 mL/s, respectively) is developed for off-line measurements and validated in combination with the WMS-based sensor. Additionally, the capability of plants to remove environmental NO is presented.

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Section: No Detection From Human Breathmentioning

confidence: 99%

Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives

et al. 2012

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“…[7][8][9][10] TDLAS has a high sensitivity, good selectivity, and high stability, both in lab and portable instruments. This technology has been widely used for the detection of gases including CO 2 .…”

Section: Introductionmentioning

confidence: 99%

Carbon Dioxide Measurement Based on Multimode Diode Laser Correlation Spectroscopy Employing Wavelength Modulation Techniques

Gao

Chen

2013

Spectroscopy Letters

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“…The wavelength-tunable lasers can be used for different applications such as the spectroscopic detection of trace gases Kosterev and Tittel (2002), industrial process control, the detection of biomarkers in the breath, which contains significant information about the health of a person Narasimhan et al (2001); Namjou et al (2006); Risby and Solga (2006), the detection of most explosives, chemical and biological agents, detrimental gases Takeuchi et al (2009Takeuchi et al ( , 2007, and high-resolution spectroscopy Wysocki et al (2005).…”

Section: Introductionmentioning

confidence: 99%

Grating-coupled external-cavity short-wavelength (λ ≈ 3.9 μm) InGaAs/InAlAs/AlAs quantum-cascade lasers

et al. 2009

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In this work, the tunability properties of short-wavelength (λ ∼ 3.9 µm) quantum-cascade lasers (QCLs) were studied, which is a first in the world at such short wavelengths. The experimental setup of an external cavity (EC) QCL was arranged in a Littrow configuration. A tuning range over 75 cm −1 has been achieved by using an uncoated 23 µm stripe-width QCL at room temperature. A single-mode operation could be obtained at 2527 and 2544 cm −1 at different grating angles by using an anti-reflection (AR) coated 23 µm ridge. A 5 µm stripe-width QCL without an AR coating could be tuned over 160 cm −1 .

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Determination of exhaled nitric oxide distributions in a diverse sample population using tunable diode laser absorption spectroscopy

Cited by 61 publications

References 18 publications

Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives

Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives

Carbon Dioxide Measurement Based on Multimode Diode Laser Correlation Spectroscopy Employing Wavelength Modulation Techniques

Grating-coupled external-cavity short-wavelength (λ ≈ 3.9 μm) InGaAs/InAlAs/AlAs quantum-cascade lasers

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