Determination of Formulation and Evaluation of Floating In situ Gel of Ciprofloxacin

Pashikanti, Shailaja; Jyothsna, B.

doi:10.9734/bpi/capr/v2/2743c

Cited by 1 publication

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“…These drugs are primarily absorbed in the proximal area of the small intestine, with minimal to no absorption taking place further down the GIT. This is usually caused by the physicochemical properties of the drugs, such as limited solubility or instability in the alkaline pH of the small intestine [ 5 , 6 , 7 ]. Drugs with a NAW usually require multiple dosing with very high drug concentrations to achieve therapeutic drug levels, with severe side effects resultantly occurring.…”

Section: Introductionmentioning

confidence: 99%

A Micro-In-Macro Gastroretentive System for the Delivery of Narrow-Absorption Window Drugs

2023

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A micro-in-macro gastroretentive and gastrofloatable drug delivery system (MGDDS), loaded with the model-drug ciprofloxacin, was developed in this study to address the limitations commonly experienced in narrow-absorption window (NAW) drug delivery. The MGDDS, which consists of microparticles loaded in a gastrofloatable macroparticle (gastrosphere) was designed to modify the release of ciprofloxacin, allowing for an increased drug absorption via the gastrointestinal tract. The prepared inner microparticles (1–4 µm) were formed by crosslinking chitosan (CHT) and Eudragit® RL 30D (EUD), with the outer gastrospheres prepared from alginate (ALG), pectin (PEC), poly(acrylic acid) (PAA) and poly(lactic-co-glycolic) acid (PLGA). An experimental design was utilized to optimize the prepared microparticles prior to Fourier Transition Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM) and in vitro drug release studies. Additionally, the in vivo analysis of the MGDDS, employing a Large White Pig model and molecular modeling of the ciprofloxacin-polymer interactions, were performed. The FTIR results determined that the crosslinking of the respective polymers in the microparticle and gastrosphere was achieved, with the SEM analysis detailing the size of the microparticles formed and the porous nature of the MGDDS, which is essential for drug release. The in vivo drug release analysis results further displayed a more controlled ciprofloxacin release profile over 24 h and a greater bioavailability for the MGDDS when compared to the marketed immediate-release ciprofloxacin product. Overall, the developed system successfully delivered ciprofloxacin in a control-release manner and enhanced its absorption, thereby displaying the potential of the system to be used in the delivery of other NAW drugs.

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Section: Introductionmentioning

confidence: 99%