Determination of galactosyl hydroxylysine in urine as a means for the identification of osteoporotic women

Can a determination of tartrate‐resistant acid phosphatase predict postmenopausal loss of bone mass?

“…Other authors [8] report a similar correlation between serum TRAP and BMD in spine and radius. Other markers of bone remodelling have shown similar correlations [32]. It is interesting to note that baseline serum TRAP values correlated well ( r = −0·62, P < 0·0001) with the per cent loss observed between the first and last BMC TB determinations.…”

Pediatric reference intervals for bone markers

“…The ratio of Gal-Hyl and Glc-Gal-Hyl is 7:1 in bone and 1:1.6 in the skin; therefore, Gal-Hyl is considered as a relatively specific marker to bone collagen degradation. Previous investigations have demonstrated that urinary levels of Gal-Hyl were increased in a number of metastatic bone diseases [57][58][59]. The urinary Gal-Hyl does not appear to be influenced by dietary collagen intake, and there is no significant metabolism after release from collagen.…”

Urinary output of hydroxylysine glycosides and pyridinium cross‐links in detecting rat bone collagen turnover rate

“…Since GHYL and GGHYL as well as PYD and DPD are the products of post-translational modifications in the pathway of collagen biosynthesis, they are not reutilized during collagen turnover [1,2]. Thus, the urinary excretion of hydroxylysine glycosides and pyridinium cross-links residues specifically reflects collagen breakdown [3][4][5][6]. Recently, these two classes of metabolites were proposed to represent markers of bone turnover in human bone diseases, with a specificity higher than that of hydroxyproline (HYP) [4,5,[7][8][9][10][11][12][13][14], due to their selective presence in type I bone collagen.…”