Determination of Glomerular Filtration Rate Per Unit Renal Volume Using Computerized Tomography:: Correlation With Conventional Measures of Total and Divided Renal Function

Tsushima, Yoshito; Blomley, Martin; Okabe, Keisuke; Tsuchiya, Kiyotaka; Aoki, Junichiro; Endo, Keigo

doi:10.1097/00005392-200102000-00007

Cited by 51 publications

(65 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The previous reports on estimation of SRF using CT data sets revealed a significant correlation between the SRF estimated by CT and that by scintigraphy data (r=0.43-0.97) (10)(11)(12)(13)(14)(15). This is in accordance with our result (r=0.93).…”

Section: Discussionsupporting

confidence: 93%

“…This is in accordance with our result (r=0.93). In the previous reports, the degree of renal enhancement was taken into consideration for the estimation of SRF (10)(11)(12)(13)(14)(15). According to Frennby et al, the glomerular filtration rate (GFR) of a kidney was assumed to be proportional to the amount of contrast medium that had accumulated in that kidney a few minutes after bolus injection, and directly proportional to the attenuation capacity of the contrast medium (CM) in that kidney, with the attenuation capacity calculated by subtracting the number of HUs of all the voxels of the kidney before CM injection from that after CM injection.…”

Section: Discussionmentioning

confidence: 99%

“…Several previous reports have compared split renal function (SRF) estimated by CT data sets with SRF estimated by renal scintigraphy (10)(11)(12)(13)(14)(15)(16). According to these reports, there is a significant relationship between SRFs estimated by the two methods (r=0.43-0.97).…”

Section: Introductionmentioning

confidence: 99%

“…In this study we used a newly developed software that estimates the kidney volume within several seconds, and evaluated the relationship between renal function and the renal volume thus estimated. Furthermore, we also evaluated a method for assessment of SRF by CT data using the degree of renal enhancement and renal volume, as presented in previous reports (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry

Kato

Kamishima

Morita

et al. 2011

European Journal of Radiology

View full text Add to dashboard Cite

Rapid Estimation of Split Renal Function in Kidney Donors using software developed for Computed Tomographic Renal Volumetry AbstractPurpose: To evaluate the speed and precision of split renal volume(SRV) measurement (SRV), which is the ratio of unilateral renal volume to bilateral renal volume, using a newly developed software for computed tomographic (CT) volumetry and to investigate the usefulness of SRV for the estimation of split renal function (SRF) in kidney donors.Method: Both dynamic CT and renal scintigraphy in 28 adult potential living renal donors were the subjects of this study. We calculated SRV using the newly developed volumetric software built into a PACS viewer (n-SRV), and compared it with SRV calculated using a conventional workstation, ZIOSOFT (z-SRV). The correlation with split renal function (SRF) using 99m Tc-DMSA scintigraphy was also investigated.Results: The time required for volumetry of bilateral kidneys with the newly developed software (16.7 ± 3.9sec) was significantly shorter than that of the workstation (102.6 ± 38.9 sec, p<0.0001). The results of n-SRV (49.7 ± 4.0%) were highly consistent with those of z-SRV (49.9 ± 3.6%), with a mean discrepancy of 0.12 ± 0.84%. The SRF also agreed well with the n-SRV, with a mean discrepancy of 0.25 ± 1.65%. The dominant side determined by SRF and n-SRV showed agreement in 26 of 28 cases (92.9%).Conclusion: The newly developed software for CT volumetry was more rapid than the conventional workstation volumetry and just as accurate, and was suggested to be useful for the estimation of SRF and thus the dominant side in kidney donors.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry

Kato

Kamishima

Morita

et al. 2011

European Journal of Radiology

View full text Add to dashboard Cite

show abstract

“…Previous studies were conducted to investigate the feasibility of assessing CT GFR by using other methods (3,(5)(6)(7)(8)(24)(25)(26)(27)(28). The Patlak method is a twocompartment technique in which it is assumed that the contrast agent is fully trapped within the system at the time of measurement (29), but the complexity of tubular anatomy is neglected.…”

Section: Genitourinary Imaging: Single-kidney Glomerular Filtration Rmentioning

confidence: 99%

Determination of Single-Kidney Glomerular Filtration Rate in Human Subjects by Using CT

Kwon¹,

Saad²,

Herrmann³

et al. 2015

Radiology

View full text Add to dashboard Cite

Purpose:To test the hypothesis that computed tomography (CT)-derived measurements of single-kidney glomerular filtration rate (GFR) obtained in human subjects with 64-section CT agree with those obtained with iothalamate clearance, a rigorous reference standard. Materials and Methods:The institutional review board approved this HIPAA-compliant study, and written informed consent was obtained. Ninety-six patients (age range, 51-73 years; 46 men, 50 women) with essential (n = 56) or renovascular (n = 40) hypertension were prospectively studied in controlled conditions (involving sodium intake and renin-angiotensin blockade). Single-kidney perfusion, volume, and GFR were measured by using multidetector CT time-attenuation curves and were compared with GFR measured by using iothalamate clearance, as assigned to the right and left kidney according to relative volumes. The reproducibility of CT GFR over a 3-month period (n = 21) was assessed in patients with renal artery stenosis who were undergoing stable medical treatment. Statistical analysis included the t test, Wilcoxon signed rank test, linear regression, and Bland-Altman analysis. Results:CT GFR values were similar to those of iothalamate clearance (mean 6 standard deviation, 38.2 mL/min 6 18 vs 41.6 mL/min 6 17; P = .062). Stenotic kidney CT GFR in patients with renal artery stenosis was lower than contralateral kidney GFR or essential hypertension single-kidney GFR (mean, 23.1 mL/min 6 13 vs 36.9 mL/min 6 17 [P = .0008] and 45.2 mL/min 6 16 [P = .019], respectively), as was iothalamate clearance (mean, 26.9 mL/min 6 14 vs 38.5 mL/min 6 15 [P = .0004] and 49.0 mL/min 6 14 [P = .001], respectively). CT GFR correlated well with iothalamate GFR (linear regression, CT GFR = 0.88*iothalamate GFR, r 2 = 0.89, P , .0001), and Bland-Altman analysis was used to confirm the agreement. CT GFR was also moderately reproducible in medically treated patients with renal artery stenosis (concordance coefficient correlation, 0.835) but was unaffected by revascularization (mean, 25.3 mL/min 6 15.2 vs 30.3 mL/min 6 18.5; P = .097). Conclusion:CT assessments of single-kidney GFR are reproducible and agree well with a reference standard. CT can be useful to obtain minimally invasive estimates of bilateral single-kidney function in human subjects.q RSNA, 2015

show abstract

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Alexander

Authier

Castillo

et al. 2010

Contrast Media & Molecular

View full text Add to dashboard Cite

Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single-slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT-derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 +/- 0.058 ml min(-1) ml renal tissue(-1)) compared with control dogs (0.396 +/- 0.139 ml min(-1) ml renal tissue(-1)). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R(2) = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT-GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models.

show abstract

Determination of Glomerular Filtration Rate Per Unit Renal Volume Using Computerized Tomography:: Correlation With Conventional Measures of Total and Divided Renal Function

Abstract: Functional CT using nonionic contrast material can measure GFR normalized to renal volume and is an accurate alternative to conventional methods of renal function evaluation.

Cited by 51 publications

References 24 publications

Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry

Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry

Determination of Single-Kidney Glomerular Filtration Rate in Human Subjects by Using CT

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Contact Info

Product

Resources

About