Determination of Glomerular Filtration Rate in Adult Horses and Donkeys by Single IV Administration of Iohexol

Meucci, Valentina; Sgorbini, Micaela; Bonelli, Francesca; Corazza, Michele; Lippi, Ilaria; Intorre, Luigi; Guidi, Grazia

doi:10.1016/j.jevs.2014.11.003

Cited by 11 publications

(16 citation statements)

References 29 publications

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“…However, the existence of a difference in renal hemodynamic between horses and donkeys cannot be ruled out, given that donkeys have less arcuate arteries [21]. On the other hand, no differences were found in GFR between adult horses and donkeys in one study [29]. Interestingly, in our study the age of the horses had no effect on RRI either in horses or donkeys.…”

Section: Overall Horsescontrasting

confidence: 69%

“…Furthermore, there are no proven different physiological and/or hemodynamic features between the kidneys. As far as we know, only one study has shown 'a significant difference in the split function of the equine kidneys, with the glomerular filtration rate (GFR) of the right kidney contributing 60.1 +/-9.12% of the total function, as determined by scintigraphy [29]. The GFR is a measure of functional renal mass [27], but notably GFR and blood flow, and so the RI, are not comparable measures of renal function [28] and they cannot be directly linked at this point.…”

Section: Overall Horsesmentioning

confidence: 99%

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Doppler evaluation of renal resistivity index in healthy conscious horses and donkeys

Freccero¹,

Petrucelli²,

Cipone³

et al. 2020

PLoS ONE

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The renal resistive index (RRI) is used as a measurement of downstream resistance in arteries. The aim of this study was to assess the RRI of the arcuate arteries by pulsed-wave Doppler ultrasonography in healthy conscious horses and donkeys, and to verify any differences related to age, breed, bodyweight (BW) or body condition (BCS). Thirty-three healthy conscious horses and nine donkeys had their systolic and diastolic flow velocities at the level of the arcuate arteries estimated by pulsed-wave Doppler ultrasound, and the RRI was calculated. The relationship of RRI with age, breed (Trotters vs. other breeds), bodyweight (BW), and body condition score (BCS) were evaluated. PW Doppler evaluation of RRI was successfully applied in most of the horses, but to date not in the donkeys. In horses, median RRI values for the right kidney (0.58±0.006) were statistically higher than for the left (0.51 ±0.006). For the donkeys the values were comparable. There was no significant difference in RRI between horses younger or older than 15 years, and between breeds in horses. No correlation with age, BW or BCS was found in either horses or donkeys.

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Section: Overall Horsescontrasting

confidence: 69%

Section: Overall Horsesmentioning

confidence: 99%

Doppler evaluation of renal resistivity index in healthy conscious horses and donkeys

Freccero¹,

Petrucelli²,

Cipone³

et al. 2020

PLoS ONE

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“…Glomerular filtration rate was not significantly different between Groups A and B. In addition, the GFR values of both young horses (2.50 mL/min/kg) and aged horses with serum creatinine <1.5 mg/dL (2.20 mL/min/kg) were close to previously findings for plasma IOX clearance (2.15 mL/min/kg in foals, and 2.38 mL/min/kg and 2.36 mL/min/kg in adult horses, respectively) . In our study, aged horses with serum creatinine ≥1.5 mg/dL (Group C) showed a significantly lower GFR (1.50 mL/min/kg) than young horses (Group A).…”

Section: Discussionsupporting

confidence: 85%

“…Blood samples were centrifuged at 3000 rpm for 10 minutes. Plasma was stored in aliquots at −20°C until high‐performance liquid chromatography analysis …”

Section: Methodsmentioning

confidence: 99%

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Estimation of glomerular filtration rate by plasma clearance of iohexol in healthy horses of various ages

Lippi

Bonelli

Meucci

et al. 2019

Veterinary Internal Medicne

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BackgroundPlasma clearance of iohexol is a reliable method to assess the glomerular filtration rate (GFR). The relationship between aging and GFR in horses is unclear.Hypothesis/ObjectivesTo compare GFR estimated by iohexol clearance in horses of different ages.AnimalsTwenty‐one clinically healthy horses were enrolled.MethodsProspective study. Groups: (A) composed by 8 young horses (≤14 years old) with serum creatinine <1.5 mg/dL, (B) by 7 aged horses (≥20 years old) with serum creatinine <1.5 mg/dL, and (C) by 6 aged horses (≥20 years old) with serum creatinine ≥1.5 mg/dL. Iohexol was injected (75.5 mg/kg) through an IV catheter, and plasma samples were collected 5, 30, and 90 minutes later. Plasma clearance of iohexol was obtained by the high‐performance liquid chromatography‐ultraviolet method.ResultsThe GFR was 2., 2.1, and 1.45 mL/min/kg (median value) in Groups A, B, and C, respectively. Statistical analysis showed differences between Group A versus C for urea, Group A versus B and A versus C for creatinine, and A versus C for GFR.Conclusions and Clinical ImportanceGlomerular filtration rate was significantly reduced in aged horses with serum creatinine ≥1.5 mg/dL compared to young horses with creatinine <1.5 mg/dL; no differences were obtained between young and aged horses with creatinine <1.5 mg/dL. Glomerular filtration rate evaluation should be considered in aged horses even if the plasma creatinine values are normal.

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Renal Resistive Index as A Potential Indicator of Acute Kidney Injury in Horses

Siwińska

Żak

Słowikowska

et al. 2021

Journal of Equine Veterinary Science

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Determination of Glomerular Filtration Rate in Adult Horses and Donkeys by Single IV Administration of Iohexol

Cited by 11 publications

References 29 publications

Doppler evaluation of renal resistivity index in healthy conscious horses and donkeys

Doppler evaluation of renal resistivity index in healthy conscious horses and donkeys

Estimation of glomerular filtration rate by plasma clearance of iohexol in healthy horses of various ages

Renal Resistive Index as A Potential Indicator of Acute Kidney Injury in Horses

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