Determination of hemisphere dominance for language: comparison of frontal and temporal fMRI activation with intracarotid amytal testing

Spreer, Joachim; Arnold, Sebastian; Quiske, A.; Wohlfarth, R.; Ziyeh, Sargon; Altenmüller, Dirk‐Matthias; Herpers, M.; Kassubek, Jan; Klisch, Joachim; Steinhoff, B. J.; Honegger, Jürgen; Schulze‐Bonhage, Andreas; Schumacher, M.

doi:10.1007/s00234-002-0782-2

Cited by 118 publications

(73 citation statements)

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“…The fMRI-determined lateralization index (LI) has been shown to correlate with some versions of dichotic listening (Fernandes et al, 2006;Fontoura et al, 2008; Van den Noort et al, 2008). More convincingly, both dichotic listening (Strauss et al, 1987;Hugdahl et al, 1997;Fontoura et al, 2008) and fMRI-LI tests (Desmond et al, 1995;Yetkin et al, 1995;Spreer et al, 2002, Fontoura et al, 2008 repeatedly show a correlation with Wada test results. However, fMRI-LIs are influenced by task choice (Lee et al, 2008) and are more robust when measured in regions of interest (ROIs) rather than when derived from a whole-brain index calculation (Spreer et al, 2002).…”

Section: Introductionmentioning

confidence: 96%

“…More convincingly, both dichotic listening (Strauss et al, 1987;Hugdahl et al, 1997;Fontoura et al, 2008) and fMRI-LI tests (Desmond et al, 1995;Yetkin et al, 1995;Spreer et al, 2002, Fontoura et al, 2008 repeatedly show a correlation with Wada test results. However, fMRI-LIs are influenced by task choice (Lee et al, 2008) and are more robust when measured in regions of interest (ROIs) rather than when derived from a whole-brain index calculation (Spreer et al, 2002). In their study on language lateralization, Szaflarski and colleagues (2002) point out that fMRI-LIs depend on the locations from which the laterality is derived.…”

Section: Introductionmentioning

confidence: 97%

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Right-hemispheric brain activation correlates to language performance

et al. 2010

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Language function in the right-hemispheric homologues of Broca"s and Wernicke"s areas does not only correlate with left-handedness or pathology, but occurs naturally in righthanded healthy subjects as well. In the current study, two non-invasive methods of assessing language lateralization are correlated with behavioral results in order to link hemispheric dominance to language ability in healthy subjects.Functional Magnetic Resonance Imaging (fMRI) together with a sentence-completion paradigm was used to determine region-specific lateralization indices in the left-and rightsided Broca"s and Wernicke"s areas, the frontal temporal lobe, the anterior cingulate cortex and the parietal lobe. In addition, dichotic listening results were used to determine overall language lateralization and to strengthen conclusions by correlating with fMRI indices.Results showed that fMRI lateralization in the superior parietal, the posterior temporal, and the anterior cingulate cortices correlated to dichotic listening. A decreased right ear advantage (REA), which indicates less left-hemispheric dominance in language, correlated with higher performance in most administered language tasks, including reading, language ability, fluency, and non-word discrimination. Furthermore, right hemispheric involvement in the posterior temporal lobe and the homologue of Broca"s area suggests better performance in behavioral language tasks. This strongly indicates a supportive role of the right-hemispheric counterparts of Broca"s and Wernicke"s areas in language performance.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

Right-hemispheric brain activation correlates to language performance

et al. 2010

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“…In recent years, several studies have compared fMRI and the IAP with respect to language lateralization, or evaluated the ability of fMRI to localize language functions in children and adults with epilepsy [12][13][14][15][16][17][18][19][20][21][22][23][24]. These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31].…”

Section: Introductionmentioning

confidence: 99%

“…These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31]. Some studies have also reported the use of more than one fMRI paradigm for language localization and lateralization [10,12,13,29,32,33], but the results of these studies have been mixed, with some tasks showing good and some poor correlation with the results of IAP.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

113

137

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Functional magnetic resonance imaging (fMRI) has the potential to replace the intracarotid amobarbital procedure (IAP) in presurgical evaluation of patients with epilepsy patients. In this study, we compared fMRI verb generation (VG) and semantic decision/tone decision (SDTD) tasks and the IAP in their ability to localize language functions in patients with epilepsy undergoing presurgical evaluation. We enrolled 50 healthy controls to establish normal language activation patterns for VG and SDTD tasks at 3 or 4 T, and to design language regions of interest (ROIs) that were later applied to 38 patients with epilepsy (28 of 38 also underwent the IAP). We calculated laterality indices (LIs) for each task for each subject based on the ROIs, and we used general linear modeling to analyze the fMRI data. All healthy and epileptic subjects activated language areas with both fMRI tasks. We found significant correlations in language lateralization between the fMRI tasks (r = 0.495, P ≤ 0.001) and between VG and IAP (r = 0.652, P < 0.001) and SDTD and IAP (r = 0.735, P < 0.001). The differences in LIs between SDTD and VG tasks were small and not affected by age, gender, epilepsy status, handedness, or performance. SDTD and VG tasks combined explained approximately 58.4% in the variability of the IAP/language. In the general linear modeling, only the SDTD task significantly contributed to the determination of language lateralization in patients with epilepsy undergoing presurgical evaluation. Results indicate a moderate convergent validity between both fMRI language tasks and between IAP and fMRI tasks. The results of this study indicate that either of these fMRI tasks can be used for language lateralization in patients with epilepsy undergoing presurgical evaluation, but that the SDTD task is likely to provide more information regarding language lateralization than the VG task.

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“…Until now, extremely good correlations have been published between fMRI and the IAP, especially for epilepsy patients with a typical (i.e. left dominant) language representation (Binder et al, 1996;Yetkin et al, 1998;Lehéricy et al, 2000;Rutten et al, 2002a,b;Spreer et al, 2002;Adcock et al, 2003;Woermann et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

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Objective: To reveal differences of cerebral activation related to language functions in post-operative temporal lobe epilepsy (TLE) patients. Methods: Right (RTL) and left temporal lobe (LTL) resected patients, and healthy controls were studied using functional magnetic resonance imaging (fMRI). Only patients with complete left-hemispheric language dominance according to the intracarotid amytal procedure (IAP) were included. Language-related activations were evoked by performing word generation and text reading language tasks. Activation lateralization and temporo-frontal distribution effects were analysed. Results: For word generation, only LTL patients showed reduced left lateralized activation compared to controls, due to a decrease in activation in the left prefrontal cortex and an increase in the right prefrontal cortex. For reading, the left-hemispheric lateralization in RTL patients increased because of enhanced activity in the left prefrontal cortex, whereas for LTL patients the activation became bilaterally distributed over the temporal lobes. Lateralization results between pre-operative IAP and postoperative fMRI were highly discordant. Significant temporo-frontal distribution changes manifested from the reading but not from the word generation task. * Corresponding author. Backes et al. / Epilepsy Research 66 (2005) [1][2][3][4][5][6][7][8][9][10][11][12] Conclusion: The cerebral language representation in post-operative LTL epilepsy patients is more bi-hemispherically lateralized than in controls and RTL patients. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologuous brain areas, are suggested to contribute to the cerebral reorganisation of language function.

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Determination of hemisphere dominance for language: comparison of frontal and temporal fMRI activation with intracarotid amytal testing

Cited by 118 publications

References 33 publications

Right-hemispheric brain activation correlates to language performance

Right-hemispheric brain activation correlates to language performance

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

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