Determination of Ibuprofen in Pharmaceutical Formulations Using Differential Pulse Polarography

Abstract

A reliable differential pulse polarographic (DPP) method has been developed and applied for the determination of ibuprofen IBU in dosage form with dropping mercury electrode (DME) versus Ag/AgCl. The best peak was found at cathodic peak of -1.18 V in phosphate buffer at pH=4 and 0.025M of KNO3 as supporting electrolyte. In order to obtaine the highest sensitivity, instrumental and experimental parameters were examined including the type and concentration of supporting electrolyte, pH of buffer solution, pulse amplitude and voltage step time. Diffusion current showed a direct linear relationship to ibuprofen concentration in the range of (5 – 30) μg. mL-1 (2.43× 10-5 – 1.45 × 10-4 mol·L–1) with correlation coefficient r= 0.9999, detection limit (S/N = 3) =3.40 μg. mL-1 (1.65 × 10-5 mol·L–1) and the value of precision in terms of relative standard deviation RSD%, ranged between 0.374-0.5176 %. The established DPP method offers an excellent analytical figure of merits as well as its successful applicability to examine two commercial drug forms (tablet and suspension) for the determination of ibuprofen.

تقنية كرموتوغرافيا السائل ذات الاداء العالي ذوالطور العكسي مع كاشف الاشعة الفوق البنفسجية لتقدير ادوية الايبو بروفين والتنوكسيكام في الصورة النقية و الاقراص الدوائية

“…Similar to TNX, IBU is also soluble in distilled water and organic solvents, such as ethanol 28 . The concentration of IBU was assessed with numerous techniques, including molecular absorption spectrophotometry 29 , in which the entire spectrum was employed in conjunction with the traditional least-squares method 30 , polarography 31 , spectrophotometry 32 , ultra-HPLC with triple quadrupole mass spectrometer (UPLC-MS/MS) 33 , gas chromatography-mass-spectrometry (GC-MS) 34 , Raman spectroscopy 35 , spectrofluorometry 36 , FTIR 37 , UV-visible spectrophotometer 38 , HPLC 39 , NIR diffuse reflectance spectroscopy 40 , reverse flow injection 41 , electrochemical analysis 42 , and NMR spectroscopy 43 .…”

A Zirconia‐Nanoparticles‐Modified Carbon Paste Electrode for Voltammetric Determination of Ibuprofen

“…[50][51][52] Although the BDD electrodes allow ibuprofen voltammetric quantification at high electrode potentials without the oxygen evolution interference, currently they are not available in a recognized format similar to that of the other carbon electrodes, [47] while the commercial screen printed electrodes cannot be considered as a low-cost alternative to the carbon paste electrodes. The DME [59] provides a fresh surface for the reaction, but its application is restricted because of the mercury toxicity. The use of the traditional bare glassy carbon [20] and bare graphite [42] electrodes requires the application of tedious surface renewal procedures and additional signal processing to improve the sensitivity of the determination.…”