Determination of Landiolol in Human Plasma by High-Performance Liquid Chromatography With Fluorescence Detection

Aomori, Tohru; Matsumoto, Naoki; Nakamura, Katsunori; Fujita, Yukiyoshi; Sekizuka, Masayuki; Araki, Takuya; Nakamura, Tomonori; Yamamoto, Keiji

doi:10.1080/10826076.2011.591022

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Midodrine is also used for the treatment of hypotension related to dialysis, orthostatic hypotension, and desautonomia. [1][2][3][4][5] To date, many analytical methods have been reported for estimating the above-mentioned drug, including chromatographic, [6][7][8][9][10][11][12][13][14][15] spectrouorimetric, [16][17][18][19] spectrophotometric, [20][21][22] and electrochemical methods. [23][24][25] However, the conventional methods employed for the quantication of midodrine hydrochloride, such as high-performance liquid chromatography (HPLC), oen suffer from several limitations, such as time-consuming sample preparation and the use of expensive and highly pure organic solvents, while ultraviolet-visible (UV-vis) spectroscopy has low sensitivity and possible interference from excipients present in the formulation.…”

Section: Introductionmentioning

confidence: 99%

Utility of dansyl chloride for the establishment of a sensitive spectrofluorimetric approach for estimating midodrine hydrochloride: application to content uniformity testing

Derayea,

Abdelgaleel,

Nagi

et al. 2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Utility of dansyl chloride for the establishment of a sensitive spectrofluorimetric approach for estimating midodrine hydrochloride: application to content uniformity testing

Derayea,

Abdelgaleel,

Nagi

et al. 2023

RSC Adv.

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“…The supernatant was aliquoted to polyethylene tubes after centrifugation at 3,000 rpm for 5 min and stored at -20°C until assay. Landiolol in human plasma was stable at -20°C for at least 3 weeks, 29) and all samples were measured within 3 weeks after collection.…”

Section: Assessment Of Hepatic Blood Flowmentioning

confidence: 99%

“…Measurement of Landiolol by HPLC The concentration of landiolol was measured by HPLC with a method that we previously established 29) with minor modifications for physostigmine sulfate (2.0 mol/L). Propranolol hydrochloride solution (20 µg/mL, 5 µL) as an internal standard and 1.0 mL of ethyl acetate were added to 105 µL plasma, which was adjusted to pH 9.0 with 4.0 µL of 0.5 mol/L NaOH.…”

Section: Calculation Of Half-life Of Landiolol In Human Bloodmentioning

confidence: 99%

Influence of Hemodynamic Variations on the Pharmacokinetics of Landiolol in Patients Undergoing Cardiovascular Surgery

Matsumoto

Aomori

Kanamoto

et al. 2012

Biological & Pharmaceutical Bulletin

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Although landiolol is useful in the emergency management of atrial fibrillation, atrial flutter, and tachycardia, as well as in perioperative arrhythmia control, the influence of hemodynamic changes on the pharmacokinetics of landiolol is unknown. We investigated the influence of hemodynamic variation and the following hepatocirculatory changes after systemic heparinization on the pharmacokinetics of landiolol in patients undergoing cardiovascular surgery under cardiopulmonary bypass. Cardiac output and cardiac index (CI) were continuously monitored in 19 patients using an arterial pressure-based cardiac output monitor. The middle and right hepatic venous blood flow indexes (mHVBFI and rHVBFI) were measured by transesophageal echocardiography, and hemodynamic data were collected at points (T1-T3) as follows: T1, before administration of heparin and after sternotomy; T2, just before systemic heparinization (300 U/kg); T3, 10 min after T2. The plasma concentration of landiolol was measured by HPLC at the same point. After administration of heparin, mean arterial blood pressure, CI, mHVBFI, and rHVBFI were significantly decreased (<0.05). Heart rate was not significantly changed. After systemic heparinization, the landiolol concentration was significantly decreased from 0.407 0.251 µg·mL 1 to 0.232 0.207 µg·mL 1 (<0.01). There was no significant difference between T1 and T2 ( 0.88). In conclusion, the plasma concentration of landiolol was decreased by diminished CI due to systemic heparinization, but not affected by the change of hepatic blood flow.Key words landiolol; cardiac index; hepatic venous blood flow; heparin; HPLC; pseudocholinesterase β 1 -Blockers have been reported to decrease perioperative morbidity and mortality in patients with cardiovascular disease undergoing surgery, [1][2][3][4] and are recommended to be started as early as possible before the operation and maintained during and after surgery.5) β 1 -Blockers have been reported to be effective regulators of heart rate (HR) and sinus rhythm in postoperative atrial fibrillation and flutter, 6) which play an important role in the increased incidence of postoperative complications and the duration of hospitalization among patients requiring cardiac surgery. [7][8][9] Landiolol is an ultra-short-acting β 1 -selective adrenergic receptor-blocking agent. It is rapidly hydrolyzed to an inactive form by both carboxylesterase in the liver and pseudocholinesterase in the plasma, 10) resulting in an estimated half-life of about 4 min, which is significantly shorter than the elimination half-lives of conventional β 1 -blockers.11) In addition, landiolol hydrochloride has a much higher cardioselectivity (β 1 /β 2 =255) than currently available β 1 -blockers such as esmolol hydrochloride (β 1 /β 2 =33).10) Because of its characteristics, landiolol hydrochloride has been used in the emergency management of atrial fibrillation, atrial flutter, and tachycardia, as well as in perioperative arrhythmia control. Landiolol has been reported to attenuate tachycardia wi...

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Studying the kinetic of midodrine degradations using TLC stability approach: Application to dosage form and human plasma

Abdelgaleel

Nagi

Derayea

et al. 2023

Journal of Pharmaceutical and Biomedical Analysis

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Determination of Landiolol in Human Plasma by High-Performance Liquid Chromatography With Fluorescence Detection

Cited by 7 publications

References 7 publications

Utility of dansyl chloride for the establishment of a sensitive spectrofluorimetric approach for estimating midodrine hydrochloride: application to content uniformity testing

Utility of dansyl chloride for the establishment of a sensitive spectrofluorimetric approach for estimating midodrine hydrochloride: application to content uniformity testing

Influence of Hemodynamic Variations on the Pharmacokinetics of Landiolol in Patients Undergoing Cardiovascular Surgery

Studying the kinetic of midodrine degradations using TLC stability approach: Application to dosage form and human plasma

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