Determination of lymph node micrometastases in patients with supraglottic carcinoma

Xu, Yaping; Zhao, Xue-qun; Guan, Ming; Binghua, LI; Zhou, Yan; Zhou, Fang

doi:10.1080/00016480701200327

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…Nieuwenhuis et al found that the survival of patients with cN0 but with one or more micrometastases (detected by molecular analysis) was worse compared to patients without micrometastases (10). Similar results were published by Xu et al (18)(19) and Yamazaki et al (21). Presence of unrecognized micrometastases or ones left in situ can also explain regional tumor recurrence in patients with N0 stage or in patients with N+ stage after selective neck dissection.…”

Section: Discussionsupporting

confidence: 72%

“…On the other hand, the presence of micrometastases is clinically significant (8,(18)(19)(20). Nieuwenhuis et al found that the survival of patients with cN0 but with one or more micrometastases (detected by molecular analysis) was worse compared to patients without micrometastases (10).…”

Section: Discussionmentioning

confidence: 99%

“…Many authors in recent years have focused on detection of HNSCC micrometastases using immunohistochemical methods. Positive results in patients with clinical N0 stage varies widely from 2 to 58% (13)(14)(15)(16)(17)(18), which indicates that the methods for detection are not united and the percentage of positive results depends on the experience of the pathologist. In our study, micrometastases or ITC were detected in 5 cases (42%), 4 patients (33%) had a metastases of SCC and 1 patient (9%) had an accidental finding of PTC micrometastasis.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Čelakovský

Kalfeřt

Smatanová

et al. 2015

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary:Background: The goal of this prospective study was to determine the frequency of micrometastases in patients with squamous cell carcinoma (SCC) of the oral cavity, pharynx and larynx in whom elective neck dissection was indicated (cN0). Patients and Methods: A total of 12 patients (10 males and 2 females) were enrolled in the study. The age ranged 42-73 years (median 62 years). Elective neck dissection was performed in all patients (8 ipsilateral, 4 bilateral) and a total of 256 lymph nodes were removed and sent for microscopic examination. Results: The presence of tumor cells in cervical lymph nodes was found in 5/12 (42%) patients. Micrometastases of SCC were found in two patients and isolated tumor cells (ITC) in two other patients. In the remaining one patient with oropharyngeal SCC, a micrometastasis of papillary thyroid carcinoma (PTC) was detected. Positive lymph nodes were localized in level II in three patients with SCC of larynx, hypopharynx and tongue base, respectively, in level I in one patient with SCC of oral tongue and in level III in one patient with PTC. Conclusion: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Čelakovský

Kalfeřt

Smatanová

et al. 2015

Acta Med. (Hradec Kralove, Czech Repub.)

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“…The CK19‐positive rate in cancerous tissue of patients with oral squamous cell carcinoma was 91% detected using immunohistochemistry . It is considered to be a highly sensitive and useful marker for detecting lymph node metastasis in various types of cancer, including head and neck squamous cell carcinoma …”

Section: Discussionmentioning

confidence: 99%

“…26 It is considered to be a highly sensitive and useful marker for detecting lymph node metastasis in various types of cancer, including head and neck squamous cell carcinoma. 27,28 This protein is expressed in most, but not all, breast cancer cases. Although the 1-step nucleic acid amplification assay has proven useful in breast cancer, this prevalent expression of CK19 suggests there is a risk of false negative results by the 1-step nucleic acid amplification assay when testing CK19-negative patients who have breast cancer 10 and, similarly, those with head and neck squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic potential of 1‐step nucleic acid amplification assay in patients with head and neck squamous cell carcinoma based on CK19 expression in a primary lesion

et al. 2015

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Detection of lymph node micrometastases in patients with squamous carcinoma of the head and neck

Ferlito

Rinaldo

Devaney

et al. 2008

Eur Arch Otorhinolaryngol

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While the significance of large cervical node metastases in patients with head and neck squamous carcinomas is well established, the import of a finding of regional nodal micrometastases (where a micrometastasis is defined as a metastatic deposit greater than 0.2 mm and not greater than 2.0 mm in greatest dimension) or isolated tumor cells in those patients is less clearly understood. Some earlier investigators have suggested that finding micrometastases does not have an impact on prognosis; some later investigators, however, have taken issue with this position, arguing that finding either micrometastases or isolated tumor cells might portend a poorer prognosis for head and neck cancer patients. At this juncture, it is difficult to advance a single recommendation for handling a finding of micrometastases or isolated tumor cells. It would be helpful if two courses of action were followed: first, while the detection of micrometastases and isolated tumor cells remains an investigatory practice, data should be collected and analyzed with an eye to discerning whether such findings are indeed of significance to the individual head and neck cancer patient. Second, rigorous definitions of micrometastases and isolated tumor cells (such as the definitions suggested here) should be developed and widely employed so as to permit ready comparison between the results as they are reported by different investigators.

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Determination of lymph node micrometastases in patients with supraglottic carcinoma

Cited by 9 publications

References 17 publications

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Diagnostic potential of 1‐step nucleic acid amplification assay in patients with head and neck squamous cell carcinoma based on CK19 expression in a primary lesion

Detection of lymph node micrometastases in patients with squamous carcinoma of the head and neck

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