Determination of macrolide antibiotics in meat and fish by liquid chromatography–electrospray mass spectrometry

Determination of macrolide and lincosamide antibiotics by pressurised liquid extraction and liquid chromatography-tandem mass spectrometry in meat and milk

“…According to the literature (Berrada et al, 2008;Horie, Takegami, Toya, & Nakazawa, 2003;Juan, González, Soriano, Moltó, & Mañes, 2005) temperature and pressure are the most important variables that can affect the extraction efficiency by PLE because the solubility power is increased. In order to see if extraction could be improved, it was decided to perform various experiments with acetonitrile by changing temperature (20, 40, 70 and 95 C) and pressure (500, 1000, 1500, and 2000 psi).…”

Extraction of trace acetylspiramycin in real aqueous environments using aqueous two-phase system of ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate and phosphate

“…Therefore, it has been widely used in the rearing of food-producing animals to prevent and treat diseases. Therapeutic activities on humans and animals can consequently lead to ASPM residues in aqueous environments which may have direct toxic effects on consumers [20]. In pharmacopoeias, bioassay and high performance liquid chromatographic (HPLC) methods are usually used for assay of ASPM and thin-layer chromatographic (TLC) methods for identification [21].…”

A Fully Automatic HPLC–CAD–DAD Method Coupled with ASE and Online SPE for Simultaneous Determination of Seven Antibiotics in Bio-Matrices

“…As a result, the presently proposed method yielded LODs as low as that achieved by the reported MS approaches [28] (the costs of acquisition and maintenance of the MS system should be much higher). Some of the HPLC-DAD or HPLC-FLD methods [29][30][31][32] could also achieve such sensitivity, but these methods required complicated extraction and offline enrichment pretreatments, which lengthened sample pretreatment time and increased the risk of sample loss. The use of online SPE in the presently proposed method could avoid these issues and save much labor, organic solvent and time.…”