Determination of magnetic particle distribution in biomedical applications by X-ray microtomography

Brunke, Oliver; Odenbach, S.; Fritsche, C.; Hilger, Ingrid; Kaiser, Werner A.

doi:10.1016/j.jmmm.2004.11.120

Cited by 19 publications

(11 citation statements)

References 4 publications

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“…Because of the small particle size, ferrofluids involved nanoscience and nanotechnology from their inception. With modern advances in understanding nanoscale systems, current research focuses on synthesis, characterization, and functionalization of nanoparticles with magnetic and surface properties tailored for application as micro/nanoelectromechanical sensors, actuators, and micro/nanofluidic devices [20 & ]; and for such biomedical applications as [20 & ,21 && ] nanobiosensors, targeted drug-delivery vectors [22], magnetocytolysis of cancerous tumors, hyperthermia [23], separations and cell sorting, magnetic resonance imaging [24,25], immunoassays [26], radiolabelled magnetic fluids [27], and X-ray microtomography for three dimensional analysis of magnetic nanoparticle distribution in biological applications, a crucial parameter for therapeutic evaluation [28].…”

Section: Ferrofluid Compositionmentioning

confidence: 99%

Magnetic fluid rheology and flows

Rinaldi

Chaves

Elborai

et al. 2005

Current Opinion in Colloid & Interface Science

187

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Section: Ferrofluid Compositionmentioning

confidence: 99%

Magnetic fluid rheology and flows

Rinaldi

Chaves

Elborai

et al. 2005

Current Opinion in Colloid & Interface Science

187

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“…Let us notice that we assume that in tissue MNPs were injected in a vein and distributed in tumor without guidance. MNPs clustering was reported in [15], where 10 nm sized MNPs created a disordered cluster structure with the mean period about 200 µm. The calculations were made for two values of blood perfusion characterized by linear blood velocity values, v = 5 cm/s and 10 cm/s.…”

Section: Temperature Distributions In Tissue Heatedmentioning

confidence: 97%

“…From a practical point of view the mean period of the cluster structure could be more easily adjusted for the purposes of turning temperature profiles than that in the case of single MNPs dispersed in a tumor. Thus, it can be assumed that a cluster structure of MNPs appears, for example, as a result of the biodistribution of MNPs in tumors [15]. To describe the cluster structure of MNPs we introduce two parameters: R cl , the cluster radius, and p, the mean spatial period of clusters.…”

Section: Modelmentioning

confidence: 99%

Magnetic Heating by Tunable Arrays of Nanoparticles in Cancer Therapy

2009

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Detailed knowledge about the temperature distribution achieved in the target area is essential for the development of magnetic hyperthermia treatments. However, the temperature inhomogeneity was found in all local hyperthermia studies. As a consequence of the impossibility of guaranteeing the temperature and thus the thermal dose distribution, hyperthermia is never applied as a single treatment modality. We suggest a model that enables the calculations and optimization of the spatial-time distribution of the temperature in the target volume (i.e. tumor) caused by magnetically heated elements: (i) arrays of clusters of iron oxides magnetite (Fe 3 O 4 ) magnetic nanoparticles, and (ii) arrays of magnetic needles. In order to find the spatial-time temperature distribution in tumor, the bioheat transfer equation is solved for the two above-mentioned arrays of magnetically heated sources embedded in the tumor. The temporal and spatial temperature distributions were calculated with regard to the effect of blood perfusion in the tumor. It is shown that a matrix of magnetic micro-needles injected in the tumor could provide rather uniform tumor heating with the center-edge temperature difference smaller than 3• C at any times during the magnetic hyperthermia treatments. The temperature profiles can be suitably adjusted by a proper choice of the magnetic nanoparticles arrangement.

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“…Gupta & M.Gupta, 2005;Reimer & Weissleder, 1996) and X-ray synchrotron radiation micro-CT it is possible to provide detailed information on the stem cell migration in 3D, which are not attainable by traditional methods based on 2D techniques. In particular, micro-CT can give a relative local snapshot of the nanoparticle distribution (Brunke et al, 2005), with high spatial resolution images (from 10 μm to 1 μm) and high signal-to-noise ratio (Peyrin et al, 1998;Salomé et al, 1999). Synchrotron radiation microtomography can be used for investigating the capacity of human stem cells to repair muscle damage in Duchenne Muscular Dystrophy.…”

Section: X-ray Microtomography: Outline Of the Techniquementioning

confidence: 99%