Determination of maternal risk factors of preterm delivery: adjusted for sparse data bias; results from a population-based case-control study in Iran

Valipour, Mehrdad; Ayubi, Erfan; Shiravand, Narges; Moradi, Yousef; Abbaszadeh, Abolfazl; Amrai, Firooz; Mokhtari, Shahin; Bahmanpour, Kaveh; Mansori, Kamyar

doi:10.5468/ogs.2020.63.2.117

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Out of 250 newborns included in the study, 180 [72%] were FT and 70 [28%] were LPT. More than half of LPT newborns are admitted to NICU [Neonatal intensive care] [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Preterm birth: causes and complications observed in tertiary care hospitals

Koteswari¹,

Lakshmi²,

Yaseen³

et al. 2022

Cell. Mol. Biomed. Rep.

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and it eventually selected 80 pregnant women for the final experiment. Those pregnant women who had preeclampsia, intrahepatic cholestasis during pregnancy, placenta previa or chorioamnionitis were more likely to experience pre-term birth. A patient interview was conducted in a detailed manner and all the necessary information regarding the mother and the infant were collected to carry out the study. Among 80 patients, collected the highest number of 39 cases i.e. 49% in between the age group of 17-23 years and the least number of cases therefore 19 i.e. 24% in between the age group of 35-45 years. We studied that maternal variable such as social status and educational status also impacts deliveries. Alcoholics had the highest number of very pre-term deliveries i.e., 36.25%. And among undergraduates, moderate preterm deliveries were a predominant number, i.e. 38.75%. Among the cases collected, 22.5% of women who have previous abortions had the highest number of preterm births with 31 cases and 5% of women with thyroid had the least number of pre-term births. 41% of preemie births were observed in the gestational gap of < 18 months, while 24% were recorded in > 30 months. In between two types of deliveries, 69% of preemie births were observed in the cesarean section and normal delivery includes 31%. The results of our study reveal that there is a need to assess the causes and complications among pregnant women who are at risk of delivering a premature baby. We have concluded that counseling the patients about their risk factors is necessary, and the patients should be told that harmful social habits will have a huge impact on their baby, before or after the delivery.

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“…Out of 250 newborns included in the study, 180 [72%] were FT and 70 [28%] were LPT. More than half of LPT newborns are admitted to NICU [Neonatal intensive care] [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Preterm birth: causes and complications observed in tertiary care hospitals

Koteswari¹,

Lakshmi²,

Yaseen³

et al. 2022

Cell. Mol. Biomed. Rep.

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RSVpreF vaccination in pregnancy: a meta-analysis of maternal-fetal safety and infant efficacy

Marchand,

Massoud,

Abdelsattar

et al. 2024

Obstet Gynecol Sci

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In May 2023, the United States Food and Drug Administration approved a Pfizer©-sponsored (Pfizer, New York, NY, USA) bivalent respiratory syncytial virus prefusion F protein-based vaccine (RSVpreF) RSV vaccine (AbrysvoTM [Pfizer]) for use during pregnancy to prevent neonatal/infant RSV infection. In February of 2022, trials sponsored by GSK© (Brentford, England, UK) on a similar RSVpreF vaccine were halted because of the identification of a safety signal related to preterm births. As these vaccines use identical pre-fusion F-protein technology, we sought to synthesize the existing data on their effectiveness and safety. We identified all randomized controlled trials and used RevMan 5.4.1 (The Cochrane Collaboration, England, UK) to perform the analysis with 95% confidence intervals and risk ratios (RRs). We found many maternal side effects were more prevalent in the RSVpreF group, with more local reactions, blood disorders, fatigue, joint pain, cardiac disorders, headache, fever, gastrointestinal disorders and pregnancy complications. The vaccinated group demonstrated significant reductions in RSV-lower respiratory tract cases (RR, 0.44 [0.33, 0.57]; P<0.00001), severe respiratory illness (RR, 0.29 [0.19, 0.44]; P<0.00001), and hospitalizations (RR, 0.40 [0.24, 0.67]; P=0.0005). RSVpreF vaccination was associated with a higher incidence of preterm delivery (RR, 1.24 [1.08, 1.44]; P=0.003). No significant difference in neonatal deaths was observed (RR, 1.42 [0.70, 2.89]; P=0.34). In conclusion, RSVpreF vaccination results in systemic adverse events and an increase in preterm delivery. Vaccination appears to have acceptable short-term newborn safety, but is not related to a significant decrease in neonatal death.

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Determination of maternal risk factors of preterm delivery: adjusted for sparse data bias; results from a population-based case-control study in Iran

Cited by 2 publications

References 28 publications

Preterm birth: causes and complications observed in tertiary care hospitals

Preterm birth: causes and complications observed in tertiary care hospitals

RSVpreF vaccination in pregnancy: a meta-analysis of maternal-fetal safety and infant efficacy

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