Determination of minor impurities in terazosin hydrochloride by high-performance liquid chromatography

A sensitive and reliable method for therapeutic monitoring of α1-blockers in rabbit plasma by ion-pair chromatography with enhanced fluorescence detection

“…The proposed IPC-FL method was found to be 1000 times more sensitive than HPLC-UV method [28][29][30][31][32][33] but less sensitive than LC-Mass method [38][39][40][41]; However, LC-MS was more expensive technique and needed technical experience. These results indicated the reliability of the proposed IPC-FL for the assay of the studied α1-blockers.…”

“…A major problem encountered during the analysis of these drugs was attributed to the strong spectral overlapping of similar drugs such as PRZ, TER, and DOX in their respective real samples [28]. Additionally, the bad resolutions obtained for some chromatographic methods and laborious extraction procedures limit the use of the others [28][29][30][31][32][33][34].…”

“…These methods included UV-Visible spectrophotometry [7-11], spectrofluorimetry [12][13][14], flow injection analysis (FIA) [15][16][17], voltammetry [18][19], potentiometry [20][21], high-performance thin layer chromatography (HPTLC) [22][23][24][25][26][27], and high-performance liquid chromatography (HPLC) with UV detection [28][29][30][31][32][33], fluorescence detection [34][35][36][37] and mass detection [38][39][40][41].…”

Synthesis and content determination of impurity A of terazosin for use to establish a reference standard for terazosin drug quality control

“…The IAT obtained can be used to establish a reference standard substance for terazosin drug quality control. impurity A of terazosin (IAT: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)piperazine, dihydro chloride), a degradation product of terazosin 4,5 ( Figure 2) for related substances test. So, we decided to investigate the synthesis and purification of IAT.…”

Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

“…Several methods for determination of this drug have been reported in the literature, including high performance liquid chromatography [5][6][7][8][9][10][11][12][13][14][15][16], capillary zone electrophoresis [17], spectrofluorimetry [18,19], X-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate [20] and voltammetric methods [19,20]. Electrochemical methods have received considerable interest due to their higher selectivity, lower detection limit, lower cost and faster operation than other reported methods [21,22].…”