Determination of montelukast sodium in human plasma by column-switching high-performance liquid chromatography with fluorescence detection

High-performance liquid chromatographic determination of montelukast sodium in human plasma: Application to bioequivalence study

“…No difference in pharmacokinetics was noted between dosing in the morning or in the evening [8,10]. Various analytical methods have been developed to determine montelukast in human plasma samples, such as LC-MS-MS [9,11], radiochromatographic [12], HPTLC [13], voltammetry [14], and chromatographic assays [15][16][17][18][19][20][21][22][23]. The use of columns switching [16][17], microtiter plate [19], and dual-column [20] has also been incorporated with the process of highperformance liquid chromatographic (HPLC) analysis.…”

“…Various analytical methods have been developed to determine montelukast in human plasma samples, such as LC-MS-MS [9,11], radiochromatographic [12], HPTLC [13], voltammetry [14], and chromatographic assays [15][16][17][18][19][20][21][22][23]. The use of columns switching [16][17], microtiter plate [19], and dual-column [20] has also been incorporated with the process of highperformance liquid chromatographic (HPLC) analysis. Some methods do not use internal standards [17,20], whereas other methods use synthetic derivatives [15][16]19], quinine bisulfate [18], mefenamic acid [21], or ethoxyquin [23] as internal standards.…”

“…The use of columns switching [16][17], microtiter plate [19], and dual-column [20] has also been incorporated with the process of highperformance liquid chromatographic (HPLC) analysis. Some methods do not use internal standards [17,20], whereas other methods use synthetic derivatives [15][16]19], quinine bisulfate [18], mefenamic acid [21], or ethoxyquin [23] as internal standards. Literature survey revealed that there is high variation in the limit of quantitation as reported by different authors (0.25 ng mL −1 [11]; 1-50 ng mL −1 [15][16][17][18][19][20][21][22][23]).…”

Development and validation of RP-HPLC method with ultraviolet detection for estimation of montelukast in rabbit plasma: Application to preclinical pharmacokinetics

“…To name few of these modifications are stereo-selective detection with column switching technique. 8,9 After consideration of all published reports regarding bioanalysis of MKS, there are certain common attributes which can easily be cited. Almost all reported methods had preferentially used protein precipitation method for extraction of MKS and fluorescence detector for quantification.…”

Method development and validation for the simultaneous determination of fexofenadine hydrochloride and montelukast sodium using rp-hplc

“…Similarly for Montelukast sodium, UV spectrophotometry [19,20], spectrofluorometry [21], RP-HPLC [22,23], HPTLC [24,25], plasma HPLC [26,27,28,29], LC/MS [30,31], and stability indicating HPLC methods [32,33] have been reported.…”