Determination of N-nitrosomethylaniline and methylaniline in the gas phase

Abstract

Abstract. A method is described for selective sampling and determination of gaseous N-nitrosomethylaniline (NMA) and methylaniline (MA) in air without artifacts. Therefore a denuder system is developed to distinguish between the amine and the nitroso compound during sampling. A spatial separation of the gas phase of these compounds is realized. The detection is performed after gas chromatographic separation with a thermal energy analyzer (TEA) for the nitrosamine and with flame ionization detector (FID) for the amine and nitrosamine. Besides the sampling technique, the extraction of the samples and detection principles are described. To prove that the formation of artifacts does not appear, the influence of humidity and nitrogen oxides was investigated.

Rapid and Simple Extraction Method for Volatile N-Nitrosamines in Meat Products

“…Moreover, some known inhibitors of the nitrosation reaction, such as ascorbic acid, are used in the processing of several foods [9]. The determination of nitrosamines in food and water samples has been carried out by different analytical methods, including colorimetry [10,11], capillary electro-chromatography [12], micellar electrokinetic capillary chromatography [13], gas chromatography with flame ionization detection, nitrogen phosphorous detection, thermal energy detection, nitrogen chemiluminescence detection [14][15][16][17], and mass spectrometry detection [18][19][20], high-performance liquid chromatography with thermal energy analyzer, mass spectrometry and fluorescence detection [21,22]. The extraction of the nitrosamine from the complex food matrices and the cleanup of the extract have been the critical points of the sample preparation step, and several approaches are documented in the literatures, including distillation (steam or vacuum) [23][24][25], solvent extraction, [26] solid-phase extraction [27], solid-phase micro-extraction (SPME) [28], and supercritical fluid extraction [29].…”

Probenahme und analytische Bestimmung von Gasen und Dämpfen [Air Monitoring Methods in German language, 2006]

“…Zur besseren Handhabbarkeit wurden Annular-Denuder entwickelt, die aus mehreren konzentrisch angeordneten Glasrohren bestehen [14]. Denuder sind in der Regel nur stationär einsetzbar.…”

Determination of Seven Volatile N-Nitrosamines in Fast Food

“…The International Agency for Research on Cancer (IARC) classified N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) as most carcinogenic to humans, and N-nitrosodi-n-butylamine (NDBA), N-ni-trosopiperidine (NPIP) and N-nitrosopyrrolidine (NPYR) as possibly carcinogenic to humans [11]. The determination of nitrosamines in food and water samples has been carried out by different analytical methods [12], including colorimetry [13], capillary electro-chromatography [14], micellar electro-kinetic capillary chromatography [15], gas chromatography with flame ionization detection, nitrogen phosphorous detection, thermal energy detection, nitrogen chemiluminescence detection [16][17][18][19], mass spectrometry detection [20][21][22], high-performance liquid chromatography with thermal energy analyzer, mass spectrometry and fluorescence detection [23,24]. The extraction of the nitrosamine from the complex food matrices and the cleanup of the extract have been the critical points of the sample preparation step, and several approaches are documented in the literatures, including distillation (steam or vacuum) [25][26][27], solvent extraction [28], solid-phase extraction [29], solid-phase micro-extraction (SPME) [30] and supercritical fluid extraction [31].…”