Determination of newly synthesized dihydroxylated polybrominated diphenyl ethers in sea fish by gas chromatography-tandem mass spectrometry

Zhang, Mengtao; Guo, Wei; Wei, Juntong; Shi, Jianghong; Zhang, Jiawei; Ge, Hui; Tao, Huanyu; Liu, Xiaowei; Hu, Qing; Cai, Zongwei

doi:10.1016/j.chemosphere.2019.124878

Cited by 9 publications

(6 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extraction by a solvent is the classic sample preparation technique, which includes liquid-liquid extraction (LLE), soxhlet extraction, solid-liquid extraction (SLE), microwave-assisted extraction (MAE), ultrasonic extraction (USE), accelerated solvent extraction (ASE), and supercritical fluid extraction (SFE) [14][15][16][17][18][19][20][21][22]. Improved extraction methods, such as pressurized liquid extraction (PLE), can increase the diffusion rate and solubility of interferences into the matrix [23,24]. Increasing common clean-up automation and improving instrument design has created a surge in the use of solid-phase extraction (SPE) in a variety of applications has been observed [25,26].…”

Section: Preparation Methods For the Analysis Of Svocs Or Thermally Stable Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Gao

Wang³

et al. 2021

Foods

View full text Add to dashboard Cite

Food safety and quality have been gaining increasing attention in recent years. Gas chromatography coupled to tandem mass spectrometry (GC–MS/MS), a highly sensitive technique, is gradually being preferred to GC–MS in food safety laboratories since it provides a greater degree of separation on contaminants. In the analysis of food contaminants, sample preparation steps are crucial. The extraction of multiple target analytes simultaneously has become a new trend. Thus, multi-residue analytical methods, such as QuEChERs and adsorption extraction, are fast, simple, cheap, effective, robust, and safe. The number of microorganic contaminants has been increasing worldwide in recent years and are considered contaminants of emerging concern. High separation in MS/MS might be, in certain cases, favored to sample preparation selectivity. The ideal sample extraction procedure and purification method should take into account the contaminants of interest. Moreover, these methods should cooperate with high-resolution MS, and other sensitive full scan MSs that can produce a more comprehensive detection of contaminants in foods. In this review, we discuss the most recent trends in preparation methods for highly effective detection and analysis of food contaminants, which can be considered tools in the control of food quality and safety.

show abstract

Section: Preparation Methods For the Analysis Of Svocs Or Thermally Stable Compoundsmentioning

confidence: 99%

“…QuEChERS is a suitable preparation method for PBDEs detection; however, when using other extraction methods, lipids and proteins need to be removed from the sample by using KOH solution/n-hexane partition or GPC process. Lipids and pigments that remain in the extract can be removed using the Florisil cartridge [23,112].…”

Section: Bfrsmentioning

confidence: 99%

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Gao

Wang³

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…Because of all these steps, the analysis is particularly long and expensive. The development of S-PLE methods allowed the analysis of these contaminants in food matrices involving fat removal directly in the extraction cell (in the presence of clean-up sorbent) in order to obtain extracts suitable for direct GC analysis [16][17][18]20] or further purification steps (SPE) [22,23].…”

Section: Edcsmentioning

confidence: 99%

Pressurized Liquid Extraction: A Powerful Tool to Implement Extraction and Purification of Food Contaminants

Barp

Višnjevec

Moret

2023

Foods

View full text Add to dashboard Cite

Pressurized liquid extraction (PLE) is considered an advanced extraction technique developed in the mid-1990s with the aim of saving time and reducing solvent with respect to traditional extraction processes. It is commonly used with solid and semi-solid samples and employs solvent extraction at elevated temperatures and pressures, always below the respective critical points, to maintain the solvent in a liquid state throughout the extraction procedure. The use of these particular pressure and temperature conditions changes the physicochemical properties of the extraction solvent, allowing easier and deeper penetration into the matrix to be extracted. Furthermore, the possibility to combine the extraction and clean-up steps by including a layer of an adsorbent retaining interfering compounds directly in the PLE extraction cells makes this technique extremely versatile and selective. After providing a background on the PLE technique and parameters to be optimized, the present review focuses on recent applications (published in the past 10 years) in the field of food contaminants. In particular, applications related to the extraction of environmental and processing contaminants, pesticides, residues of veterinary drugs, mycotoxins, parabens, ethyl carbamate, and fatty acid esters of 3-monochloro-1,2-propanediol and 2-monochloro-1,3-propanediol from different food matrices were considered.

show abstract

“…Agarwal et al [ 11 ] reported marine bacteria as producers of OH-PBDEs and established a genetic and molecular foundation for their production. Now, it is widely believed the OH-PBDEs in the food chain mainly come from the biosynthesis of ocean microorganisms rather than commercial PBDE products [ 12 ] In our previous investigation, OH/diOH-PBDEs were also detected in sea fish available in markets, indicating the potential risk of human exposure to these compounds [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormone Receptor Agonistic and Antagonistic Activity of Newly Synthesized Dihydroxylated Polybrominated Diphenyl Ethers: An In Vitro and In Silico Coactivator Recruitment Study

Zhang,

Shi,

et al. 2024

Toxics

Self Cite

View full text Add to dashboard Cite

Dihydroxylated polybrominated diphenyl ethers (DiOH-PBDEs) could be the metabolites of PBDEs of some organisms or the natural products of certain marine bacteria and algae. OH-PBDEs may demonstrate binding affinity to thyroid hormone receptors (TRs) and can disrupt the functioning of the systems modulated by TRs. However, the thyroid hormone disruption mechanism of diOH-PBDEs remains elusive due to the absence of diOH-PBDEs standards. This investigation explores the potential disruptive effects of OH/diOH-PBDEs on thyroid hormones via competitive binding and coactivator recruitment with TRα and TRβ. At levels of 5000 nM and 25,000 nM, 6-OH-BDE-47 demonstrated significant recruitment of steroid receptor coactivator (SRC), whereas none of the diOH-PBDEs exhibited SRC recruitment within the range of 0.32–25,000 nM. AutoDock CrankPep (ADCP) simulations suggest that the conformation of SRC and TR–ligand complexes, particularly their interaction with Helix 12, rather than binding affinity, plays a pivotal role in ligand agonistic activity. 6,6′-diOH-BDE-47 displayed antagonistic activity towards both TRα and TRβ, while the antagonism of 3,5-diOH-BDE-100 for TRα and TRβ was concentration-dependent. 3,5-diOH-BDE-17 and 3,5-diOH-BDE-51 exhibited no discernible agonistic or antagonistic activities. Molecular docking analysis revealed that the binding energy of 3,3′,5-triiodo-L-thyronine (T3) surpassed that of OH/diOH-PBDEs. 3,5-diOH-BDE-100 exhibited the highest binding energy, whereas 6,6′-diOH-BDE-47 displayed the lowest. These findings suggest that the structural determinants influencing the agonistic and antagonistic activities of halogen phenols may be more intricate than previously proposed, involving factors beyond high-brominated PBDEs or hydroxyl group and bromine substitutions. It is likely that the agonistic or antagonistic propensities of OH/diOH-PBDEs are instigated by protein conformational changes rather than considerations of binding energy.

show abstract

Determination of newly synthesized dihydroxylated polybrominated diphenyl ethers in sea fish by gas chromatography-tandem mass spectrometry

Cited by 9 publications

References 45 publications

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Pressurized Liquid Extraction: A Powerful Tool to Implement Extraction and Purification of Food Contaminants

Thyroid Hormone Receptor Agonistic and Antagonistic Activity of Newly Synthesized Dihydroxylated Polybrominated Diphenyl Ethers: An In Vitro and In Silico Coactivator Recruitment Study

Contact Info

Product

Resources

About