Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol–gel fiber coating

Yazdi, Ali Sarafraz; Amiri, Amirhassan; Rounaghi, Gholam Hossein; Eshtiagh‐Hosseini, Hossein

doi:10.1016/j.jchromb.2012.09.040

Cited by 60 publications

(18 citation statements)

References 36 publications

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“…This approach was used previously for the SPME of organics in samples containing humic acids [25] and proteins. [16,28] Application of a protective film should prevent any interaction between the nanoparticulate complexes and the solid phase, including the extensive aggregation of nanoparticulate species at the solid phase-bulk medium interface. Thus we also performed the extraction of triclosan from the aqueous SiO 2 nanoparticle dispersion by PDMS protected with a dialysis membrane with pore size ,5 nm.…”

Section: Membrane-protected Spmementioning

confidence: 99%

“…the accumulation process was controlled by the diffusion limited partitioning of the free diclofenac. [16] In the present work, the focus is on a more involved system, namely triclosan in the presence of sorbing SiO 2 nanoparticles that enter the solid phase PDMS. We shall consider the role of the nanoparticulate species, analyse the potential interferences and suggest possible ways to get around them.…”

Section: Introductionmentioning

confidence: 99%

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Solid phase microextraction speciation analysis of triclosan in aqueous media containing sorbing nanoparticles

Zielińska¹

2014

Environ. Chem.

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Environmental context. Speciation analysis of organic compounds in aquatic media is often performed using solid phase microextraction with the assumption that only the free organic form is accumulated. We show that in the presence of silica nanoparticles, this interpretation is confounded by partitioning of nanoparticulate-bound compounds between water and the solid phase, as well as their aggregation at solid-bulk medium interfaces. Equilibrium measurement of the target analyte is feasible if the solid phase is protected by a suitable membrane.Abstract. Solid phase microextraction (SPME) is applied in the speciation analysis of the hydrophobic compound triclosan in an aqueous medium containing sorbing SiO 2 nanoparticles (NPs). It is found that these NPs, as well as their complexes with triclosan, partition between the bulk medium and the solid phase poly(dimethylsiloxane) (PDMS). Furthermore, they appear to aggregate at the PDMS-water interface. The total triclosan concentration in the solid phase thus includes both the free and the NP-bound forms. Proper computation of the analyte concentration in the sample medium requires (i) consideration of the speciation of triclosan inside the solid phase and (ii) elimination of the effects of aggregation of NP complexes at the solid phase-bulk medium interface. Possible solutions include application of a protective membrane with pore size smaller than the NP diameter. This allows measurement of the free triclosan concentration, albeit at the cost of longer accumulation times and loss of kinetic information on the triclosan-NP complex.Additional keyword: SPME.

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Section: Membrane-protected Spmementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solid phase microextraction speciation analysis of triclosan in aqueous media containing sorbing nanoparticles

Zielińska¹

2014

Environ. Chem.

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“…The preconcentration factors were calculated by the equations provided in the sub‐section 2–5, and they revealed that the method provided preconcentration factors in the range of 47–53. The comparisons made between the developed method and some other microextraction techniques used for determination of the understudied drugs in terms of the speed, extraction recovery, LOD, and preconcentration factor (Table ) showed that the proposed method was very fast so that it was accomplished in just about 5 min . The final analyzer system used in the method was HPLC‐UV.…”

Section: Resultsmentioning

confidence: 99%

Determination of acidic drugs in biological and environmental matrices by membrane‐based dual emulsification liquid‐phase microextraction followed by high‐performance liquid chromatography

Moradi

Asghari

2019

J of Separation Science

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A simple method is introduced providing a highly clean microextraction for the determination of some anti‐inflammatory drugs as the model analytes in human urine and environmental matrices. This method is based upon the implementation of two consecutive emulsification liquid‐phase microextractions, which are separated by a syringe filtration step. In this method, the organic extraction solvent (dihexyl ether) is dispersed into the aqueous sample solution (20 mL), and the resulting cloudy mixture is passed through a hydrophilic polytetrafluoroethylene syringe filter. By this action, the extraction phase containing the analytes and many interfering species that could be transferred into the organic phase is retained behind the hydrophilic membrane. The filter is then detached from the syringe and attached to another syringe containing an aqueous solution (pH 12.0, 150 μL), and by the in‐syringe dispersion of the organic phase into the aqueous phase, the analytes are selectively back‐extracted into the aqueous phase. The developed method is centrifuge‐free and very simple, and provides a high sample clean‐up in a few minutes. Under the optimized experimental conditions, the developed method provided a linearity in the range of 2.0–2000 ng/mL, a low limit of detection (0.5 ng/mL), and enrichment factors of 47–53.

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Section: Introductionmentioning

confidence: 99%

“…Determination of NSAIDs in aqueous matrices has been attempted using chromatographic methods such as gas chromatography (GC), gas chromatography/mass spectrometry (GC/MS), high-performance liquid chromatography (HPLC), and liquid chromatography/mass spectrometry (LC/MS). [4][5][6][7] Moreover, various sample preparation methods have been investigated, with most of them based on traditional solid-phase extraction (SPE) and liquidliquid extraction (LLE) techniques. However, SPE methods utilize costly disposable SPE cartridges and require large volumes of organic solvents to condition/wash these cartridges and extract analytes, whereas LLE consumes large amounts of samples and organic extraction solvents, additionally suffering from long sample preparation times.…”

Section: Introductionmentioning

confidence: 99%

Determination of Non‐Steroidal Anti‐Inflammatory Drugs in Urine by HPLC–UV/Vis Analysis Coupled with Electromembrane Extraction

Kim

Myung

2018

Bulletin Korean Chem Soc

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A simple, effective, and environment‐friendly sample preparation method featuring electromembrane extraction followed by high‐performance liquid chromatography analysis was developed for the simultaneous determination of non‐steroidal anti‐inflammatory drugs (indoprofen, ketoprofen, naproxen, and ibuprofen) in human urine. Optimization was performed for parameters such as sample dilution, liquid membrane type, donor/acceptor solution pH, stirring speed, voltage, and extraction time. For spiked samples, the limits of detection and quantitation equaled 0.20–0.27 and 0.68–0.84 μg/mL, respectively, with the accuracy and precision in the working range equaling 95.1–128.4 and 2.71–10.2%, respectively. Linear equations used for quantitative analysis were valid in the concentration range of 0.68–8.4 μg/mL, with correlation coefficients (R) equaling 0.9934–0.9979.

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Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol–gel fiber coating

Cited by 60 publications

References 36 publications

Solid phase microextraction speciation analysis of triclosan in aqueous media containing sorbing nanoparticles

Solid phase microextraction speciation analysis of triclosan in aqueous media containing sorbing nanoparticles

Determination of acidic drugs in biological and environmental matrices by membrane‐based dual emulsification liquid‐phase microextraction followed by high‐performance liquid chromatography

Determination of Non‐Steroidal Anti‐Inflammatory Drugs in Urine by HPLC–UV/Vis Analysis Coupled with Electromembrane Extraction

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