Determination of nucleating agents in plastic materials by GC/MS after microwave-assisted extraction with in situ microwave-assisted derivatization

Sternbauer, Lucas; Dieplinger, Johanna; Buchberger, Wolfgang; Marosits, Edit

doi:10.1016/j.talanta.2014.04.022

Cited by 16 publications

(18 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accelerated solvent extraction [ 19 , 20 ] and microwave-assisted extraction [ 21 ] have been used in the literature for the extraction of additives from plastics. In this study, we investigated a liquid-solid extraction based on sonication and stirring to leach out the main additives from the plastics as a simpler procedure for screening purposes.…”

Section: Resultsmentioning

confidence: 99%

Screening of additives in plastics with high resolution time-of-flight mass spectrometry and different ionization sources: direct probe injection (DIP)-APCI, LC-APCI, and LC-ion booster ESI

2016

View full text Add to dashboard Cite

Plastics are complex mixtures consisting of a polymer and additives with different physico-chemical properties. We developed a broad screening method to elucidate the nature of compounds present in plastics used in electrical/electronic equipment commonly found at homes (e.g., electrical adaptors, computer casings, heaters). The analysis was done by (a) solvent extraction followed by liquid chromatography coupled to high accuracy/resolution time-of-flight mass spectrometry (TOFMS) with different ionization sources or (b) direct analysis of the solid by ambient mass spectrometry high accuracy/resolution TOFMS. The different ionization methods showed different selectivity and sensitivity for the different compound classes and were complementary. A variety of antioxidants, phthalates, UV filters, and flame retardants were found in most samples. Furthermore, some recently reported impurities or degradation products derived from flame retardants were identified, such as hydroxylated triphenyl phosphate and tetrabromobisphenol A monoglycidyl ether.Graphical abstractWide screening of plastic additives by direct probe injection (DIP)-APCI, LC-APCI and LC-ion booster ESIElectronic supplementary materialThe online version of this article (doi:10.1007/s00216-015-9238-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

Screening of additives in plastics with high resolution time-of-flight mass spectrometry and different ionization sources: direct probe injection (DIP)-APCI, LC-APCI, and LC-ion booster ESI

2016

View full text Add to dashboard Cite

show abstract

“…There has been little research to date on sorbitol-based NCAs in FCMs in the literature [2,4]. The lack of commercial analytical standards with known purity is problematic in analyzing FCM additives [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The authors have also reported a recurrent issue with NCAs, which is their poor solubility in most organic solvents. The issue was solved by using tetrahydrofuran (THF) as an extraction solvent [4]. In another work, Lopes et al reported the identification and analysis of FCM no.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a UHPLC-qTOF MS Method for the Determination of Sorbitol-Based Nuclear Clarifying Agents in Food Simulants after Migration from Food Contact Materials

2021

View full text Add to dashboard Cite

Nuclear clarifying agents (NCAs) are a class of substances frequently used as additives in the production of polymers to improve their physical properties. Some are EU regulated under Commission Regulation (EU) no. 10/2011 can be used as additives in the production of food contact plastics. However, limited analytical methods for their analysis are currently available, in part due to poor solubility in most common organic solvents and lack of analytical standards of known purity. In this work, a simple and sensitive method was developed to analyze 4 EU-regulated sorbitol-based nucleating agents in food simulants, following solubility studies to establish effective solvents. The method was shown to be accurate and precise and can be used with official food simulant D1 (50% v/v ethanol/H2O). Application to other ethanolic simulants is also possible, but due to solubility issues, a posteriori conversion of those simulants into simulant D1 is required. Finally, the method was applied to quantify the target analytes in simulants after migration testing with polypropylene (PP) beverage cups.

show abstract

“… used microwave‐assisted derivatization to determination of tranexamic acid in various matrices with the reaction time within 4 min. Nucleating agents in plastic materials were successfully determined by GC–MS after microwave‐assisted derivatization with only 10 min . Although microwave technology has been widely applied in many areas of synthetic organic chemistry, to our knowledge, there is no report about microwave‐assisted chiral derivatization (MACD) used in chiral analysis.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective analysis of bambuterol in human plasma using microwave‐assisted chiral derivatization coupled with ultra high performance liquid chromatography and tandem mass spectrometry

Zhou

Zeng

Zhao

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

In this study, an enantioselective analytical method based on microwave-assisted chiral derivatization coupled with ultra high performance liquid chromatography and tandem mass spectrometry was developed for the determination of bambuterol enantiomers in human plasma. The chiral derivatization reaction was greatly accelerated by microwave irradiation. Under the optimized conditions, both the derivatization time and separation time on column was only 3 min, and the lower limit of quantification was 2.5 pg/mL. The recoveries were in the range of 90.1-93.0% without significant matrix effect. Compared with the conventional heating chiral derivatization, microwave-assisted chiral derivatization obtained higher chiral derivatization yields with much shorter time due to the effect of microwave irradiation. Furthermore, the racemization during the derivatization reaction was systematically investigated. The results showed the concentration of acetic acid and the reaction time had significant effects on the racemization, which could be well controlled during microwave-assisted chiral derivatization for the short reaction time. Finally, this novel approach was demonstrated by determining bambuterol in human plasma of a clinical pharmacokinetic study in eight healthy volunteers. On the basis of the results, microwave-assisted chiral derivatization coupled with ultra high performance liquid chromatography and tandem mass spectrometry as a simple and effective enantioselective analysis technique for the determination of chiral drugs in complex biological samples showed great promise.

show abstract

Determination of nucleating agents in plastic materials by GC/MS after microwave-assisted extraction with in situ microwave-assisted derivatization

Cited by 16 publications

References 15 publications

Screening of additives in plastics with high resolution time-of-flight mass spectrometry and different ionization sources: direct probe injection (DIP)-APCI, LC-APCI, and LC-ion booster ESI

Screening of additives in plastics with high resolution time-of-flight mass spectrometry and different ionization sources: direct probe injection (DIP)-APCI, LC-APCI, and LC-ion booster ESI

Development and Validation of a UHPLC-qTOF MS Method for the Determination of Sorbitol-Based Nuclear Clarifying Agents in Food Simulants after Migration from Food Contact Materials

Enantioselective analysis of bambuterol in human plasma using microwave‐assisted chiral derivatization coupled with ultra high performance liquid chromatography and tandem mass spectrometry

Contact Info

Product

Resources

About