Determination of oleuropein using multiwalled carbon nanotube modified glassy carbon electrode by adsorptive stripping square wave voltammetry

Herein, electrochemical behavior of cholecalciferol on a multiwalled carbon nanotube modified glassy carbon electrode was evaluated by using cyclic voltammetry. Voltammetric determination of cholecalciferol on the prepared modified electrode was carried out using linear sweep voltammetry. A good linearity was obtained with a correlation coefficient of 0.9914 between 5×10 -5 -1×10 -3 M. The LOD and LOQ values were calculated as 1.7×10 -5 and 5.1×10 -5 M, respectively. The response of the proposed electrode was sufficiently repeatable for determining cholecalciferol. Finally, the proposed modified electrode was successfully applied to the determination of cholecalciferol in a commercial oral solution that contains 300.000 I.U cholecalciferol/mL. A simple liquid-liquid extraction technique by using methanol was followed to extract cholecalciferol from the oral liquid. The results obtained with the proposed method were in agreement with cholecalciferol content of the commercial oral solution.Özet. Bu çalışmada, kolekalsiferolün çok duvarlı karbon nanotüp modifiye camsı karbon elektrot üzerindeki elektrokimyasal davranışı, döngüsel voltammetri yöntemi kullanılarak değerlendirilmiştir. Hazırlanan modifiye elektrot yüzeyinde kolekalsiferolün voltammetrik tayini, doğrusal taramalı voltammetri yöntemi kullanılarak gerçekleştirilmiştir. 5×10 -5 -1x10 -3 M konsantrasyon aralığında 0.9914 korelasyon katsayısı ile iyi bir doğrusallık elde edilmiştir. LOD ve LOQ değerleri sırasıyla 1.7×10 -5 ve 5.1×10 -5 M olarak hesaplanmıştır. Önerilen elektrodun cevabı kolekalsiferolün belirlenmesi için yeterince tekrarlanabilirdir. Önerilen modifiye elektrot, 300.000 I.U kolekalsiferol/mL içeren ticari bir oral solüsyonda kolekalsiferol tayini için başarıyla uygulanmıştır. Oral solüsyondan kolekalsiferolü ekstrakte etmek için metanol kullanılarak gerçekleştirilen basit bir sıvı-sıvı ekstraksiyon tekniği izlenmiştir. Önerilen yöntem ile elde edilen sonuçlar, ticari oral solüsyonun kolekalsiferol içeriği ile uyum içerisindedir.Anahtar Kelimeler: Kolekalsiferol, Çok duvarlı karbon nanotüp, Voltammetri.

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“…The MWCNT was prepared as described in the previous study [21]. 40 mg MWCNT was boiled in an adequate amount of HNO 3 .…”

Section: Pre-treatment Of Mwcnt and Preparation Of Mwcnt/gcementioning

confidence: 99%

Electrochemical Behavior of Cholecalciferol on a Multiwalled Carbon Nanotube Modified Glassy Carbon Electrode

Kahya

Cittan

Çelik

2018

Cumhuriyet Science Journal

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“…The conventional electrodes have poor performance to analytes due to the easy deterioration of electrode surface by the analyte and related intermediates, thus many researchers prefer to study with the modified electrodes . Among various kinds of modifiers, carbon nanotubes (CNTs) have attracted tremendous interest since it possess high surface‐to‐volume ratio, excellent conductivity, chemical stability and also have ability to be easily functionalized and modified to surfaces . All of these features make CNTs one of the most‐preferred in the modification of the electrodes.…”

Section: Introductionmentioning

confidence: 99%

Poly(Taurine‐Glutathione)/Carbon Nanotube Modified Glassy Carbon Electrode as a New Levofloxacin Sensor

Koçak

2019

Electroanalysis

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A new highly sensitive and selective electrochemical levofloxacin sensor based on co‐polymer‐carbon nanotube composite electrode was developed. Taurine and Glutathione were electrochemically co‐polymerized on multiwalled carbon nanotubes modified glassy carbon electrode (Poly(TAU‐GSH)/CNT/GCE) and used as a levofloxacin sensor in pH 6 phosphate buffer solution. The new composite electrode surfaces were characterized by scanning electron microscopy, atomic force microscopy and electrochemical impedance spectroscopy. Under the optimized conditions, two linear segments were obtained for increasing LEV concentrations between 20 nmol L−1‐1 μmol L−1 and 1.5 μmol L−1‐55 μmol L−1 LEV with a detection limit of 9 nmol L−1 using amperometry. Poly(TAU‐GSH)/CNT/GCE exhibited high sensitivity, selectivity with good stability. The new sensor was employed for real samples of LEV tablets and urine. Promising results were obtained with good accuracy which were also in accordance with LC‐MS/MS analysis.

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“…Further improvements in these techniques in terms of sensitivity, selectivity, enhanced surface area, and catalytic effects can be achieved by modifying the surfaces of the electrodes with specific materials [23][24][25][26]. Multi-walled carbon nanotubes (MWCNT), first discovered in 1991 [27], are especially attractive as electrode modifiers, due to their excellent electronic, thermal, mechanical, and catalytic properties [28,29]. From the electrochemical perspective, their use increases the active area and improves electron transfer reactions, resulting in higher detection capability and better peak separation [30,31].…”

Section: Introductionmentioning

confidence: 99%

Adsorptive stripping voltammetry for simultaneous determination of hydrochlorothiazide and triamterene in hemodialysis samples using a multi-walled carbon nanotube-modified glassy carbon electrode

Hudari

Souza

Zanoni

2018

Talanta

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Hemodialysis is the most commonly used method for the treatment of chronic kidney disease. In this procedure, some patients use diuretics to control weight gain and blood pressure. In this work, a voltammetric sensor based on a glassy carbon electrode modified with carbon nanotubes (GCE/MWCNT) is described for the simultaneous determination of the diuretics hydrochlorothiazide (HCT) and triamterene (TRT). The oxidation of the diuretics on the GCE/MWCNT surface was observed at 1.01 and 1.17V for HCT and TRT, respectively, allowing simultaneous determination, which was not possible with the unmodified glassy carbon electrode. The GCE/MWCNT electrode provided 6-fold and 10-fold gains in anode peak intensity for HCT and TRT, respectively, compared to the unmodified electrode. After optimization of the conditions (pH, accumulation time, and accumulation potential), analytical curves were constructed for the analytes in the range from 1.0 × 10 to 2.0 × 10molL. The detection limits for HCT and TRT were 2.8 × 10 and 2.9 × 10molL, respectively. A high performance liquid chromatography method with diode array detection was also developed for the determination of HCT and TRT in hemodialysis samples, for comparison with the electroanalytical method.

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Determination of oleuropein using multiwalled carbon nanotube modified glassy carbon electrode by adsorptive stripping square wave voltammetry

Cited by 24 publications

References 29 publications

Electrochemical Behavior of Cholecalciferol on a Multiwalled Carbon Nanotube Modified Glassy Carbon Electrode

Electrochemical Behavior of Cholecalciferol on a Multiwalled Carbon Nanotube Modified Glassy Carbon Electrode

Poly(Taurine‐Glutathione)/Carbon Nanotube Modified Glassy Carbon Electrode as a New Levofloxacin Sensor

Adsorptive stripping voltammetry for simultaneous determination of hydrochlorothiazide and triamterene in hemodialysis samples using a multi-walled carbon nanotube-modified glassy carbon electrode

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