Determination of orbifloxacin in sheep plasma by high performance liquid chromatography with ultraviolet detection after intravenous and intramuscular administration

Dudhatra, Ghanshyam; Kumar, Avinash; Awale, Madhavi; Kamani, Divyesh R.; Chauhan, Bhavesh N.; Patel, Hasmukh S.; Mody, Shailesh K.

doi:10.1016/j.vascn.2012.11.002

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Orbifloxacin exhibited a relatively high volume of distribution at steady‐state (Vss; 1.86 l/kg) in crucian carp, which suggests that this drug would be distributed well into the tissues. The Vss determined here was consistent with those reported for orbifloxacin in dogs and camels (1.61 and 1.73 l/kg, (Gebru et al., ) and (Goudah & Abo‐El‐Sooud, ); respectively), but lower than that in sheep (3.09 l/kg, (Dudhatra et al., )) and higher than those reported in lactating goats and ewes (1.13 and 1.31 l/kg, (Marin, Escudero, Fernandez‐Varon, & Carceles, ) and (Goudah et al., ); respectively). The Vss is a clearance independent parameter, which is used to calculate the amount of drug in the body under equilibrium conditions (Toutain & Bousquet‐Melou, ).…”

Section: Discussionsupporting

confidence: 91%

“…After intramuscular injection, orbifloxacin was completely absorbed with a bioavailability of 96.46%. Similar values have been reported in other species, such as camels (97.47%; (Goudah & Abo‐El‐Sooud, )), dogs (100.1%; (Gebru et al., )), cows (101.4%; (Elias et al., )), goats (105.01%; (Marin et al., )), lactating ewes (114.63%; (Goudah et al., )), and sheep (150.8%; (Dudhatra et al., )). However, the intramuscular bioavailability in crucian carp of the present study was greater than that reported in ducks (72.46%–74.8%; (Tohamy, )).…”

Section: Discussionsupporting

confidence: 79%

“…and intramuscular (i.m.) dose of 7.5 mg/kg at 25°C (Goudah et al, 2009)), and sheep (150.8%; (Dudhatra et al, 2013)). However, the intramuscular bioavailability in crucian carp of the present study was greater than that reported in ducks (72.46%-74.8%; (Tohamy, 2011)).…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration

Yang

Wang

Shi

et al. 2018

Vet Pharm & Therapeutics

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The pharmacokinetics of orbifloxacin was studied after a single dose (7.5 mg/kg) of intravenous or intramuscular administration to crucian carp (Carassius auratus) reared in freshwater at 25°C. Plasma samples were collected from six fish per sampling point. Orbifloxacin concentrations were determined by high-performance liquid chromatography with a 0.02 μg/ml limit of detection, then were subjected to noncompartmental analysis. After intravenous injection, initial concentration of 5.83 μg/ml, apparent elimination rate constant (λ ) of 0.039 hr , apparent elimination half-life (T ) of 17.90 hr, systemic total body clearance (Cl) of 75.47 ml hr kg , volume of distribution (Vz) of 1,948.76 ml/kg, and volume of distribution at steady-state (Vss) of 1,863.97 ml/kg were determined, respectively. While after intramuscular administration, the λ , T , mean absorption time (MAT), absorption half-life (T ), and bioavailability were determined as 0.027 hr , 25.69, 10.26, 7.11 hr, and 96.46%, respectively, while the peak concentration was observed as 3.11 ± 0.06 μg/ml at 2.0 hr. It was shown that orbifloxacin was completely but relatively slowly absorbed, extensively distributed, and slowly eliminated in crucian carp, and an orbifloxacin dosage of 10 mg/kg administered intravenously or intramuscularly would be expected to successfully treat crucian carp infected by strains with MIC values ≤0.5 μg/ml.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 79%

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Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration

Yang

Wang

Shi

et al. 2018

Vet Pharm & Therapeutics

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“…We do not know the reason for this huge difference. But a relatively small K aim (0.13 hr −1 , calculated as 1/MAT) was also reported in sheep (Dudhatra et al., ).…”

Section: Discussionmentioning

confidence: 62%

“…In the present model, the P X s for orbifloxacin in different tissues were calculated based on area method or optimized using the pub- (Dudhatra et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits

Yang

Shi

et al. 2018

Vet Pharm & Therapeutics

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To predict the orbifloxacin concentrations in rabbits after multiple routes of administration, a flow-limited multiroute physiologically based pharmacokinetic (PBPK) model was developed. Three routes of administration (IV, IM, and PO) were incorporated into this model. Physiological parameters including tissue weights and blood flows through different tissues were obtained from the literature. The tissue/plasma partition coefficients (P s) for noneliminating tissues were calculated according to the area method, while the P s for kidney and the rest of the body compartment, together with other parameters for absorption and elimination, were optimized based on the published concentrations. The comparisons between predicted and observed orbifloxacin concentrations proved its validity, and the present model predicted available concentration data well, including those in liver, kidney, muscle, lung, heart, and plasma after oral, intravenous, or intramuscular administration. A local sensitivity analysis was also performed, which showed that the parameters for oral absorption were most influential on the orbifloxacin concentrations. This model was used to predict plasma and tissue concentrations after multiple oral or intramuscular administration. This study demonstrated the feasibility of predicting drug residues in minor species after multiple routes of administration in the extra-label manner using the PBPK modeling.

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Liquid chromatography–tandem mass spectrometry for rapid and selective simultaneous determination of fluoroquinolones level in human aqueous humor

Alhusban

Tarawneh

Dawabsheh

et al. 2019

Journal of Pharmacological and Toxicological Methods

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Determination of orbifloxacin in sheep plasma by high performance liquid chromatography with ultraviolet detection after intravenous and intramuscular administration

Cited by 6 publications

References 20 publications

Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration

Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits

Liquid chromatography–tandem mass spectrometry for rapid and selective simultaneous determination of fluoroquinolones level in human aqueous humor

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