Determination of Organochlorine Pesticides Residues in Human Adipose Tissue, Data from Cukurova, Turkey

Dağlioğlu, Nebīle; Gülmen, Mete Korkut; Akçan, Ramazan; Efeoglu, Pinar; Yener, Fadile; Ünal, İlker

doi:10.1007/s00128-010-0057-2

Cited by 28 publications

(9 citation statements)

References 18 publications

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“…Comparison of HCB, DDE, and DDT data from our cohort of five noncancer participants with those of the general population in Belgium (Covaci et al, 2002), however, do not show major differences. Recently published data from background populations in Mexico (Herrero-Mercado et al, 2010;Waliszewski et al, 2010) and Turkey (Daglioglu et al, 2010), however, show higher values for these countries compared with our data. These higher values are understandable given that phasing out of OCPs in Mexico and Turkey did not occur as early as in the USA and legal enforcement on the ban of these chemicals may not be as stringent in some jurisdictions compared with America.…”

Section: Resultscontrasting

confidence: 83%

Chlorinated pesticides and cancer of the head and neck

Govett¹,

Genuis

Govett³

et al. 2011

European Journal of Cancer Prevention

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Cancer of the head and neck is a pervasive problem with recognized determinants including tobacco use, alcohol consumption, and earlier radiation exposure. Organochlorine pesticides (OCPs) have been shown to have carcinogenic potential in both animals and humans. OCPs have previously been widely used in the agricultural industry of rural Oklahoma. Seven patients from rural Oklahoma with head and neck cancer and without any of the usual risk factors were tested for the presence of OCPs in their adipose tissue. Clinical and toxicological data on each of these patients are presented for consideration. Results were compared with (i) levels from five individuals not experiencing cancer but who lived in the same area, and (ii) adipose tissue OCP levels in other population groups. Each of the seven patients tested had markedly elevated levels of some OCPs in their adipose tissue compared with the cohort of noncancer patients. Further research is required to confirm whether there is a causative link between OCP bioaccumulation and head and neck cancer as suggested by this case series.

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Section: Resultscontrasting

confidence: 83%

Chlorinated pesticides and cancer of the head and neck

Govett¹,

Genuis

Govett³

et al. 2011

European Journal of Cancer Prevention

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“…Previous studies have also found higher POPs concentrations in older people (Apostoli et al, 2005;Arrebola et al, 2012a;Hansen et al, 2010;Hardell et al, 2010;Jakszyn et al, 2009;Rivas et al, 2007). A positive association between age and POPs burden could be assumed on the basis of the persistence and bioacumulative properties of these chemicals in human fatty tissues, as well as the continuous exposure of the population (Arrebola et al, 2009;Burgaz et al, 1994;Daglioglu et al, 2010;Waliszewski et al, 1995). A cohort effect has also been described in relation to this association, given that older people might have accumulated higher POP concentrations because they were born when these chemicals were widely employed (Ahlborg et al, 1995;Arrebola et al, 2012b;Glynn et al, 2003;Jakszyn et al, 2009).…”

Section: Predictors Of Serum Pop Concentrationsmentioning

confidence: 85%

Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions

Fernández-Rodríguez

Arrebola

Artacho‐Cordón

et al. 2015

Science of The Total Environment

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“…Thus, the presence of OCPs in maternal blood and placental tissue represents prenatal exposure hazards for fetuses because these pesticides tend to bioaccumulate in lipid-rich tissue due to their strong lipophilic nature and slow biodegradability. Daglioglu et al have reported the concentration of OCPs in female adipose tissue was significantly higher than in male, and OCPs may accumulate more in women due to a higher percentage of body fat (Daglioglu et al 2010). Therefore, women and developing fetuses are subjected to greater risk due to OCP exposure, and OCP exposure may be responsible for antagonistic effect on growth and development of the fetus.…”

Section: Discussionmentioning

confidence: 96%

Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population

Tyagi

Garg

Mustafa

et al. 2015

Environ Monit Assess

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Organochlorine pesticides (OCPs) have been widely used in public health and agriculture programs in developed as well as developing countries, including India. Being xenoestrogenic in nature, OCPs may act as endocrine disruptors leading to preterm birth (PTB) through disturbance of normal estrogen-progesterone ratio. PTB is the leading cause of neonatal deaths worldwide. Therefore, the present study is aimed to determine the extent to which persistent environmental chemicals may accumulate in pregnant women and placenta and ascertain possible associations between exposure level and period of gestation (POG), baby weight, and/or placental weight in PTB cases. Maternal blood and placenta samples of PTB cases (n = 50) and subjects of term delivery as controls (n = 50) were collected. OCP residue levels were estimated by the gas chromatography system equipped with an electron capture detector. Significantly higher levels of α-hexachlorocyclohexane (α-HCH), β-hexachlorocyclohexane (β-HCH), dichlorodiphenyldichloroethane (DDD), and dichlorodiphenyldichloroethylene (DDE) were found in maternal blood of PTB cases as compared to control. Significantly higher levels of DDE and dichlorodiphenyltrichloroethane (DDT) were also found in placental tissue of PTB cases as compared to control group. There was a statistically significant negative correlation between maternal blood level of α-HCH and birth-weight (r = -0.299) and POG (r = -0.234). γ-Hexachlorocyclohexane (γ-HCH) and dieldrin had a negative correlation with placental weight (r = -0.401 and -0.256, respectively), and DDE and β-HCH had a negative correlation with POG (r = -0.251 and -0.229, respectively). The presence of OCPs in maternal blood and placental tissue represents prenatal exposure hazard for fetuses due to chronic bioaccumulation and poor elimination with possible deleterious effect on health.

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Determination of Organochlorine Pesticides Residues in Human Adipose Tissue, Data from Cukurova, Turkey

Cited by 28 publications

References 18 publications

Chlorinated pesticides and cancer of the head and neck

Chlorinated pesticides and cancer of the head and neck

Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions

Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population

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