Determination of paeoniflorin in rat hippocampus by high-performance liquid chromatography after intravenous administration of Paeoniae Radix extract

Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration ofPaeoniae Radix extract

“…We determined the PF concentration in the cortex of normal and cerebral ischemia-reperfusion rats and plotted the time course profile of PF in rat cortex. The results revealed that PF could quickly penetrate through the BBB to reach the cortex after intravenous administration of Paeoniae Radix extract, which, together with our previous studies (He et al, 2004a), suggests that PF might directly affect certain regions of brain to exert its pharmacological effect, supporting the reports of the effects of PF on the central nervous system (CNS). In the present study, the distributions of PF in the cortex after dosing were very different in normal and cerebral ischemia-reperfusion model rats.…”

“…Our previous studies showed that PF could quickly penetrate through the blood-brain barrier (BBB) to reach rat hippocampus (He et al, 2004a), which suggests that PF may directly affect certain regions of the rat brain and support the pharmacological effect of PF. In pathological conditions, the pharmacokinetic process of a drug may be altered, and cerebral ischemiareperfusion could significantly prolong the half-life of distribution and elimination of PF in rat plasma (He et al, 2004b).…”

Peoniflorin attentuates Aβ(1–42)-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats

“…The fact that PEF could quickly penetrate through blood-brain barrier to reach the hippocampus suggests that PF may directly affect the hippocampus and improve cognitive dysfunction [34]. This study demonstrated that PEF improved cognitive deficit and neuronal degeneration induced by Aβ oligomer intrahippocampal injection in rats, and its antioxidation and maintenance of [Ca 2+ ] i homeostasis may be involved in the therapeutic effect.…”

Paeoniflorin Promotes Non-rapid Eye Movement Sleep via Adenosine A1 Receptors

“…PF can quickly cross the blood-brain barrier to reach brain tissues (He et al, 2004) and bind to R,A 1 R (Liu et al, 2005). R,A 1 R has been suggested to participate in multiple biologic activities of PF, such as antihypotension (Cheng et al, 1999), neuronal protection (Liu et al, 2005), and the antivisceral there is a hyperpolarization-activated inward rectification (due to the hyperpolarization-activated cationic current; I h , dot) and an outward rectification that delays the return of the membrane potential to the resting potential (due to A-type K + currents; I A , arrow).…”