Grapevine (Vitis spp.) is globally known as one of the essential fruit species, evidenced in the production of wine, grape juice, and other food formulations (Torregrosa et al., 2015). Its annual world production reached more than 79 million tons in 2018, being one of the world's largest fruit crops, while wine production over 29 million tones (OIV, 2019). Produced by must fermentation of grape, wine is considered a product of high commercial importance (Markoski et al., 2016).It contains polyphenols such as anthocyanins, flavonols, and stilbenes (resveratrol), which originate mainly from red grapes' seeds and skins (Flamini et al., 2013). Polyphenols are secondary metabolites, which based on their chemical structure are divided into two major groups: flavonoid and non-flavonoid compounds (Waterhouse, 2002).These natural metabolites arise from either the shikimate pathway or 'polyketide' acetate/malonate pathway, or both, producing monomeric and polymeric phenols (Lattanzio et al., 2008). The flavonoids' group comprises different flavones, flavonols, flavanones, flavanols, anthocyanins, chalcones, and dihydrochalcones (Kennedy, 2008;Waterhouse, 2002), while non-flavonoids include phenolic acids and stilbenes (Fernandes et al., 2017). A complex relationship between the factors such as temperature, sunlight, soil, water availability, and physiological process of the vine variety influence the wine quality