Determination of physical properties for β-TCP + chitosan biomaterial obtained on metallic 316L substrates

Mina, A.; Castano, Andrés Ordoñez; Caicedo, J.C.; Caicedo, H. H.; Aguilar, Y.

doi:10.1016/j.matchemphys.2015.04.041

Cited by 18 publications

(13 citation statements)

References 42 publications

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“…Owing to their high biocompatibility and bioactivity, bioceramics based on β-TCP have been widely used for bone repair in clinical applications. [38][39][40][41][42] Some researchers have also considered β-TCP to be osteoinductive. 43 In this study, bone regeneration was assessed by implanting COL/β-TCP and COL disks into critically sized rabbit calvarial defects, which were then studied after 8 weeks.…”

Section: Resultsmentioning

confidence: 99%

Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects

Tebyanian

Norahan

Eyni

et al. 2019

Journal of Applied Biomaterials & Functional Materials

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Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/β-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/β-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson's trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/β-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation.

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Section: Resultsmentioning

confidence: 99%

Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects

Tebyanian

Norahan

Eyni

et al. 2019

Journal of Applied Biomaterials & Functional Materials

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“…Tricalcium phosphate (TCP) with three polymorphs including α-TCP, β-TCP, and α′-TCP is another well-known bioceramics for bone repair applications. Β-TCP is receiving increasing attention due to its excellent biocompatibility, bioactivity, and bioresorbability [ [34] , [35] , [36] , [37] ]. Fig.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications

Alizadeh-Osgouei

Wen

2019

Bioactive Materials

243

114

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The application of various materials in biomedical procedures has recently experienced rapid growth. One area that is currently receiving significant attention from the scientific community is the treatment of a number of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites. Biomaterials, the most common materials used to repair or replace damaged parts of the human body, can be categorized into three major groups: metals, ceramics, and polymers. Composites can be manufactured by combining two or more materials to achieve enhanced biocompatibility and biomechanical properties for specific applications. Biomaterials must display suitable properties for their applications, about strength, durability, and biological influence. Metals and their alloys such as titanium, stainless steel, and cobalt-based alloys have been widely investigated for implant-device applications because of their excellent mechanical properties. However, these materials may also manifest biological issues such as toxicity, poor tissue adhesion and stress shielding effect due to their high elastic modulus. To mitigate these issues, hydroxyapatite (HA) coatings have been used on metals because their chemical composition is similar to that of bone and teeth. Recently, a wide range of synthetic polymers such as poly (l-lactic acid) and poly (l-lactide-co-glycolide) have been studied for different biomedical applications, owing to their promising biocompatibility and biodegradability. This article gives an overview of synthetic polymer-ceramic composites with a particular emphasis on calcium phosphate group and their potential applications in tissue engineering. It is hoped that synthetic polymer-ceramic composites such as PLLA/HA and PCL/HA will provide advantages such as eliminating the stress shielding effect and the consequent need for revision surgery.

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“…Трикальційфосфат з трьома поліморфними модифікаціями, зокрема, α-ТКФ, β-ТКФ і α'-ТКФ, є ще однією добре відомою біокерамічною речовиною для відновлення кісток. β-TКФ привертає все більшу увагу завдяки його чудовій біосумісності, біоактивності й здатності до біодеградації [75,89].…”

Section: проблеми застосування композиційних імплантів що біодеградують під час лікування переломівunclassified

Проблема Використання Композитних Імплантів, Що Біодеградують, У Лікуванні Переломів Кісток (Огляд Літератури)

Павлов¹,

Pastukh²,

Karpinsky³

2021

TRAUMA

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Diseases and injuries of the musculoskeletal system rank second among the causes of injuries and third among the diseases that lead to disability of the adult population. Orthopedic implants have a special place in both clinical practice and the biomedical industry. The implants capable of biodegrading in the case of their implantation into the human body are of the greatest interest. The concept of biodegra-dable implants appeared through the formation and development of the use of suture materials that are absorbed in the body. Subsequently, this type of material began to be used in the treatment of fractures, because in many cases, bone fragments need only temporary support with a fixator, until they fuse. Implantable internal fixation devices for fracture repair using polyglycolic acid (PGA), polylactic acid (PLA), and a copolymer of lactic acid and glycolide (PLGA) became popular. However, the mechanical properties of highly porous skeletons were relatively weak compared to those required for bone engineering. In the process of creating an optimal polymeric biodegradable material, it is necessary to overcome the contradiction between strength and biodegradation. PGA, providing high strength of fixation, degrade too quickly, and PLGA, having high crystallinity, slightly degrade, at the same time conceding on the durability of both PGA and biostable materials. Scientists are now working hard to develop composites from calcium phosphate and polymer, in particular hydroxyapatite and tricalсium phosphate (TCP). TCP with three polymorphic modifications, in particular α-TCP, β-TCP, and α'-TCP, is a well-known bioceramic substance for bone repair. β-TKP is attracting increasing attention due to its excellent biocompatibility, bioactivity, and biodegradability. The composite materials based on bioactive ceramics mainly refer to materials with additional advantages, such as biodegradable polymers and ceramics. At the same time, these composites are biocompatible, osteoconductive, mechanical strength and have osteogenic characteristics. At the same time, thanks to new manufacturing technologies that have emerged in recent years, these compo-site materials are the most promising in the field of bone defect repair. The treatment of fractures with implants is increasingly associated with composite materials. Biomaterials must have certain mechanical properties: biocompatibility, biodegradation, controlled rate biodegradation, good mechanical strength, and bioactivity. Biomaterials used in the treatment of bone fractures have to disintegrate over time, and the addition of nanofillers can slow down the rate of decay of the biodegradable composite.

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Determination of physical properties for β-TCP + chitosan biomaterial obtained on metallic 316L substrates

Cited by 18 publications

References 42 publications

Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects

Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects

A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications

Проблема Використання Композитних Імплантів, Що Біодеградують, У Лікуванні Переломів Кісток (Огляд Літератури)

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