Determination of plasma oxalate with oxalate oxidase

Boer, P. de; Leersum, Leo van; Endeman, H.J.

doi:10.1016/0009-8981(84)90311-5

Cited by 21 publications

(5 citation statements)

References 18 publications

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“…Nine studies published within the last two decades (1984-2005) support our results, as plasma oxalate levels obtained in adults using enzymatic method (oxalate oxidase) were similar to those determined in our studied participants aged older than 1 year [24,25,28,35,38,40,42,43,63]. The determination of plasma oxalate based on different methodological approaches in adult populations also provided similar outcomes [21,27,32,34,36,37,39,41,44,64].…”

Section: Discussionsupporting

confidence: 94%

Reference values of plasma oxalate in children and adolescents

et al. 2008

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Oxalate homeostasis is a derivative of absorption and transportation in the digestive system and renal/intestinal excretion of oxalate. The objective of this cross-sectional study was to determine normative values of plasma oxalate in relation to age, gender, and body size. A group of 1,260 healthy Caucasian children and adolescents aged 3 months to 18 years [mean +/- standard deviation (SD) 10.5 +/- 4.3] was studied. Each 1-year group comprised 70 subjects. Oxalate levels were assessed in blood plasma samples obtained from fasted individuals using the precipitation-enzymatic method with oxalate oxidase. Median oxalate levels in healthy infants was 3.20 micromol/L (5th-95th percentiles: 1.56-5.58) and was higher compared with older children [2.50 micromol/L (5th-95th percentiles: 0.95-5.74); p < 0.01]. No differences were found in plasma oxalate levels between boys and girls. There were no associations between plasma oxalate levels and anthropometric traits. In the healthy population aged 1-18 years, plasma oxalate concentration is independent of age, gender, and body size. Infants demonstrate higher plasma oxalate levels compared with older children, which suggests possible immature mechanisms of renal excretion. This study appears to be the first extensive report providing normative data for plasma oxalate in children and adolescents.

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Section: Discussionsupporting

confidence: 94%

Reference values of plasma oxalate in children and adolescents

et al. 2008

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“…The results of serum oxalate determinations in normal subjects reported by Borland et al [1] in their recent paper (0-55 um ol/l) are far out of the range found in normal subjects as determined by in vivo isotope clearance meth ods (below 3 pm ol/l) [2], The reason why in many earlier studies in which chemical methods were used concentra tions are reported exceeding these low values by one order of magnitude is not clear [3), but in more recent studies [2,3,[6][7][8][9][10][11][12][13] normal values much closer to the true value were found, i.e. at least lower than 6 pm ol/l (table 1).…”

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confidence: 67%

Plasma Oxalate in Chronic Renal Failure and Normal Subjects: Methodological Problems

Mees¹,

Boer²

1988

Nephron

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“…In general, higher Pox levels are found with chemical than with in vivo isotope clearance techniques [12][13][14]. We recently found a relationship between the enzymatically measured Pox and Pcr in 47 patients with different degrees of renal failure [15], with the equation log PO X = 0.68 log Pcr -0.68 (r = 0.84, n = 57, p < 0.001).…”

Section: Discussionmentioning

confidence: 97%

Fractional Oxalate Clearance in Subjects with Normal and Impaired Renal Function

Boer¹,

Prenen²,

Koomans³

et al. 1985

Nephron

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The ¹⁴C-oxalate clearance was determined in 13 healthy subjects and 22 patients with various diseases and varying degrees of renal functional impairment, including 5 patients with primary hyperoxaluria (PH). The clearances of oxalate (C_ox) and creatinine (C_cr) were correlated (r = 0.95). The regression line intersects the ordinate at the origin, while the regression coefficient is 2.0. This implies that the fractional C_ox is constant, irrespective of the underlying disease and the degree of renal failure. Plasma oxalate (P_ox), as calculated from the urinary oxalate excretion (U_ox) and C_ox, was elevated in patients with severely impaired kidney function and those with PH. Plasma creatinine (P_cr) and P_ox were correlated as well (r = 0.83). P_ox values of patients with PH were above the 95% confidence limits of the regression line. It is of practical importance that Pox can be estimated from U_ox and C_cr when a ¹⁴C-oxalate clearance test cannot be performed. The reasons for the constancy of the C_ox/C_cr ratio are discussed, and it is suggested that the effective renal plasma flow (ERPF) is the regulating factor for the tubular secretion of oxalate.

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Determination of plasma oxalate with oxalate oxidase

Cited by 21 publications

References 18 publications

Reference values of plasma oxalate in children and adolescents

Reference values of plasma oxalate in children and adolescents

Plasma Oxalate in Chronic Renal Failure and Normal Subjects: Methodological Problems

Fractional Oxalate Clearance in Subjects with Normal and Impaired Renal Function

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