A representative survey of current methods of solution deoxygenation is presented. Some of the novel, nonconventional methods of degassing are also highlighted. The deoxygenation methodology is examined with special emphasis on luminescence spectroscopy, reductive electrochemical analysis, high-performance liquid chromatography, and liquid chromatography with reductive electrochemical detection. Each of these areas of analytical chemistry is examined with regard to (1) the adverse effects that are caused by the presence of dissolved oxygen in samples and solutions and (2) how the current deoxygenation methodology is applicable to each analytical technique.