Determination of proinflammatory cytokines level and NF-κB activation level in the human lung cells line stimulated with essential oils for a vehicle ventilation system application

Janicka, Anna; Molska, Justyna; Zawiślak, Maciej; Czarny, Anna; Zaczyńska, Ewa

doi:10.1016/j.toxlet.2018.06.1061

Cited by 2 publications

(1 citation statement)

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“…Direct exposure of cells to the tested gases, using the BAT-CELL device, is a reproducible technique for testing the cytotoxicity of gas mixtures [ 15 ]. The method allows tests to be carried out on immission and emission in a diverse range of facilities, at workstations and in indoor environments [ 16 , 17 , 18 ]. In the present study, this method was applied to investigate the actual toxicity of engine exhaust gases.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Actual Toxicity of Engine Exhaust Gas Emissions from Euro 3 and Euro 6 Compliant Vehicles with the BAT-CELL Method Using In Vitro Tests

Kęska

Janicka

Zawiślak

et al. 2022

IJERPH

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Legal restrictions on vehicle engine exhaust gas emission control do not always go hand in hand with an actual reduction in the emissions of toxins into the atmosphere. Moreover, the methods currently used to measure exhaust gas emissions do not give unambiguous results on the impact of the tested gases on living organisms. The method used to assess the actual toxicity of gases, BAT-CELL Bio-Ambient-Tests using in vitro tests, takes into account synergistic interactions of individual components of a mixture of gases without the need to know its qualitative and quantitative composition and allows for determination of the actual toxicity of the gas composition. Using the BAT-CELL method, exhaust gases from passenger vehicles equipped with spark-ignition engines complying with the Euro 3 and Euro 6 emission standards were tested. The results of toxicological tests were correlated with the results of chromatographic analysis. It was shown that diverse qualitative composition of the mixture of hydrocarbons determining the exhaust gases toxicity may decrease the percentage value of cell survival. Additionally, it was proven that the average survival of cells after exposure to exhaust gases from tested vehicles meeting the more restrictive Euro 6 standard was lower than for vehicles meeting the Euro 3 standard thus indicating the higher toxicity of exhaust gases from newer vehicles.

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Section: Introductionmentioning

confidence: 99%