Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography

Benchaoui, H. A.; McKellar, Quintin

doi:10.1002/bmc.1130070402

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…Following oral dosing (12 mg/kg), RFX is well absorbed, reaching the maximum concentration in plasma between 24 and 48 h, but it is slowly excreted. The elimination half-life ranges from 5 to 10 days due mainly to its high protein binding [115]. Compounds against other parasites, such as nematodes and cestodes, are included in the formulation of some marketed fasciolicides.…”

Section: Salicylanilidesmentioning

confidence: 99%

The Pattern of Blood–Milk Exchange for Antiparasitic Drugs in Dairy Ruminants

Imperiale

Lanusse

2021

Animals

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The prolonged persistence of milk residual concentration of different antiparasitic drugs in lactating dairy animals should be considered before recommending their use (label or extra-label) for parasite control in dairy animals. The partition blood-to-milk ratio for different antiparasitic compounds depends on their ability to diffuse across the mammary gland epithelium. The high lipophilicity of some of the most widely used antiparasitic drugs explains their high partition into milk and the extended persistence of high residual concentrations in milk after treatment. Most of the antiparasitic drug compounds studied were shown to be stable in various milk-related industrial processes. Thus, the levels of residues detected in raw milk can be directly applicable to estimating consumer exposure and dietary intake calculations when consuming heat-processed fluid milk. However, after milk is processed to obtain milk products such as cheese, yogurt, ricotta, and butter, the residues of lipophilic antiparasitic drugs are higher than those measured in the milk used for their elaboration. This review article contributes pharmacokinetics-based information, which is useful to understand the relevance of rational drug-based parasite control in lactating dairy ruminants to avoid undesirable consequences of residual drug concentrations in milk and derived products intended for human consumption.

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Section: Salicylanilidesmentioning

confidence: 99%

The Pattern of Blood–Milk Exchange for Antiparasitic Drugs in Dairy Ruminants

Imperiale

Lanusse

2021

Animals

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“…LC-UV and thermospray LC-MS methods were described for the determination of rafoxanide in plasma and tissue [12]. In addition, a LC-UV method was described for the simultaneous determination of closantel and rafoxanide in ovine plasma [13]. HPLC with UV or FLD is generally less expensive than LC-MS/MS and thus remains the common analytical instrument in routine food safety laboratory.…”

Section: Closantel N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-metmentioning

confidence: 99%

Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS

Yeung¹,

Lee²,

Wong³

2010

J of Separation Science

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A sensitive and selective LC-FLD method was described for determination of closantel and rafoxanide in bovine and ovine muscles. Bovine and ovine muscles were extracted with ACN and acetone mixture (80:20, v/v). After cleanup with Oasis MAX SPE cartridges, the sample was analyzed by LC-FLD using the control point approach. No false-negative result was observed at or below maximum residue limits and the false-positive rate was below 5%. Suspected positive sample was confirmed by LC-MS/MS. This method was suitable for screening of large batch of samples and hence considerably reduced the time and cost required for quantitation and confirmatory analyses.

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“…Raf was determined via HPLC [15,16], GC [17], colorimetry via formation of charge transfer complex with iron III [18].…”

Section: Introductionmentioning

confidence: 99%

Comparative study on the selectivity of various spectrophotometric techniques for the determination of binary mixture of fenbendazole and rafoxanide

Saad

Attia

Elzanfaly

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography

Cited by 11 publications

References 5 publications

The Pattern of Blood–Milk Exchange for Antiparasitic Drugs in Dairy Ruminants

The Pattern of Blood–Milk Exchange for Antiparasitic Drugs in Dairy Ruminants

Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS

Comparative study on the selectivity of various spectrophotometric techniques for the determination of binary mixture of fenbendazole and rafoxanide

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