Determination of Rafoxanide in Plasma Using High Performance Liquid Chromatography (HPLC) and in Tissue Using HPLC-Thermospray Mass Spectrometry

Blanchflower, W. J.; Kennedy, D. G.; Taylor, Subhashni

doi:10.1080/01483919008048978

Cited by 10 publications

References 2 publications

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Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography

Benchaoui

McKellar

1993

Biomedical Chromatography

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A high performance liquid chromatographic method has been developed for the determination of rafoxanide and closantel in ovine plasma. Acetonitrile and chloroform were used for the extraction. The mean recoveries were 78.69% and 80.59% for rafoxanide and closantel, respectively. This method was applied to the characterization of rafoxanide plasma kinetics following oral administration of therapeutic doses to sheep.

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Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography

Benchaoui

McKellar

1993

Biomedical Chromatography

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Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS

Yeung¹,

Lee²,

Wong³

2010

J of Separation Science

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A sensitive and selective LC-FLD method was described for determination of closantel and rafoxanide in bovine and ovine muscles. Bovine and ovine muscles were extracted with ACN and acetone mixture (80:20, v/v). After cleanup with Oasis MAX SPE cartridges, the sample was analyzed by LC-FLD using the control point approach. No false-negative result was observed at or below maximum residue limits and the false-positive rate was below 5%. Suspected positive sample was confirmed by LC-MS/MS. This method was suitable for screening of large batch of samples and hence considerably reduced the time and cost required for quantitation and confirmatory analyses.

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Determination of closantel and rafoxanide in animal tissues by online anionic mixed‐mode solid‐phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry

Lai

Yeung

Lee

et al. 2011

J of Separation Science

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A rapid and high-throughput isotope dilution LC-MS/MS method with online sample pre-concentration and clean-up using anionic mixed-mode SPE was described for the determination of closantel and rafoxanide in edible bovine and ovine tissues. Tissue samples were extracted with acetonitrile and acetone mixture (60:40, v/v). Sample pre-concentration, clean-up and analysis were completed simultaneously with the online MAX SPE LC-MS/MS system. Closantel-(13) C(6) and rafoxanide-(13) C(6) were used as the internal standards to improve the precision of the method. The method was validated with edible ovine and bovine tissues (muscle, kidney and liver) fortified at three different levels. The accuracy and RSD were 86-106% and ≤14%, respectively. This high-throughput method was suitable for routine quantitative analysis of closantel and rafoxanide in food safety surveillance samples.

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Determination of Rafoxanide in Plasma Using High Performance Liquid Chromatography (HPLC) and in Tissue Using HPLC-Thermospray Mass Spectrometry

Cited by 10 publications

References 2 publications

Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography

Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography

Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS

Determination of closantel and rafoxanide in animal tissues by online anionic mixed‐mode solid‐phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry

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