Determination of Residual Solvents in Pharmaceuticals by Static Headspace Gas Chromatography Using Natural Deep Eutectic Solvents as Mediums: A Partition Coefficients Study

Zhang, Wei; Fang, Sheng; Liang, Xianrui

doi:10.1007/s10337-019-03775-0

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…Many pharmaceuticals and drug delivery systems are developed using organic solvents, so the removal of these residual solvents and its quantification through appropriate analytical methods is of great concern (Zhang, Fang, Liang, 2019). In this sense, the first legislation to address the issue was created in 1996 by the International Conference on Harmonization (ICH) with the ICH Q3C guideline, called "Impurities: Guideline for residual solvents", currently in its sixth revision.…”

Section: Encapsulation and Residual Organic Solventmentioning

confidence: 99%

Polystyrene-b-poly (acrylic acid) nanovesicles coated by modified chitosans for encapsulation of minoxidil

Hanck-Silva

Minatti

2022

Braz. J. Pharm. Sci.

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Section: Encapsulation and Residual Organic Solventmentioning

confidence: 99%

Polystyrene-b-poly (acrylic acid) nanovesicles coated by modified chitosans for encapsulation of minoxidil

Hanck-Silva

Minatti

2022

Braz. J. Pharm. Sci.

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“…hydrogen bond donor (HBD). Today, these solvents have attracted great attention in industry and academic fields because of their applicability in many technologies [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…DESs are usually formed by the interaction of quaternary ammonium salt such as ChCl with a hydrogen bond donor (HBD). Today, these solvents have attracted great attention in industry and academic fields because of their applicability in many technologies 20–22.…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvents and Layered Double Hydroxides in Solid‐Phase Extraction of Antidepressant Drugs

Khezeli

Daneshfar

2022

Chem Eng & Technol

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For the first time, an acidic deep eutectic solvent (DES) comprised of malonic acid and ChCl was used to complete dissolution of Co‐Al, Ni‐Al, and Cu‐Al layered double hydroxides (LDHs) as sorbents in the vortex‐assisted in‐situ solid‐phase extraction of doxepin and amitriptyline followed by high‐performance liquid chromatography‐ultraviolet (HPLC‐UV). Moreover, the ability of urea:ChCl and ethylene glycol:ChCl was investigated to dissolve the LDH sorbents. The extraction conditions were optimized in terms of vortex time, molar ratio of Co2+:Al3+, NaOH concentration, and volume of DES based on the Box‐Behnen design. The linearity, limit of detection, and coefficient of determination R2 for both analytes were assessed as well. Recoveries of more than 93.1 % with relative standard deviations of less than 5.3 % were achieved for spiking urine and pharmaceutical formulation samples.

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“…Several headspace techniques such as static headspace (SHS) [7][8][9][10][11], dynamic headspace [12] and headspace solid phase microextraction [5,13] can be employed. Static headspace analysis is probably the most widely used technique for residual solvent analysis in pharmaceuticals as it is inexpensive, easy to perform and automate, can be successfully used routinely in control labs.…”

Section: Introductionmentioning

confidence: 99%

“…For residual solvents determination in pharmaceuticals, water [8], dimethylsulfoxide [9,15], N,N-dimethylacetamide [16], N,N-dimethylformamide (DMF) [15], benzyl alcohol [17], liquid paraffin [18] and ionic liquids [3,11] were suggested as matrix media. Recently, for residual solvents determination deep eutectic solvents (DESs) have been proposed [7,8,19].…”

Section: Introductionmentioning

confidence: 99%

Headspace gas chromatographic analysis of residual solvents in pharmaceuticals: comparison of two matrix media

Vičkačkaitė¹,

Jevtuch²,

Poškus³

et al. 2020

chemija

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Dimethylformamide (DMF) and a deep eutectic solvent choline chloride-ethylene glycol (ChCl-Eg) were investigated as potential matrix media for static headspace gas chromatographic (SHS-GC) determination of residual solvents in pharmaceuticals. Sample equilibration temperature, equilibration time and injection time were optimized. In the case of DMF 140°C equilibration temperature was applied. For ChCl-Eg equilibration temperature could not exceed 80°C as ChCl-Eg started to degrade at elevated temperatures. The higher equilibration temperature of DMF solutions favoured a transition of the analytes to the headspace and consequently resulted in lower detection limits of the analytes. Thus DMF has been considered a more suitable matrix medium than ChCl-Eg and was applied for the SHS-GC determination of residual solvents in pharmaceuticals.

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Determination of Residual Solvents in Pharmaceuticals by Static Headspace Gas Chromatography Using Natural Deep Eutectic Solvents as Mediums: A Partition Coefficients Study

Cited by 11 publications

References 25 publications

Polystyrene-b-poly (acrylic acid) nanovesicles coated by modified chitosans for encapsulation of minoxidil

Polystyrene-b-poly (acrylic acid) nanovesicles coated by modified chitosans for encapsulation of minoxidil

Deep Eutectic Solvents and Layered Double Hydroxides in Solid‐Phase Extraction of Antidepressant Drugs

Headspace gas chromatographic analysis of residual solvents in pharmaceuticals: comparison of two matrix media

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