Determination of ropivacaine and bupivacaine in human plasma by programmed temperature vaporiser-fast gas chromatography-mass spectrometry (PTV/fast GC/MS) utilising in-vial liquid-liquid extraction

Column-switching HPLC–MS/MS analysis of ropivacaine in serum, ultrafiltrate and drainage blood for validating the safety of blood reinfusion

“…Separation was done by gas chromatography with either nitrogen-phosphorous detection (GC-NPD) or mass spectrometric detection (GC-MS) [8,[10][11][12] or by high-performance liquid chromatography with either ultra violet detection (HPLC-UV) [1-4,] or mass spectrometric detection (HPLC-MS, HPLC-MS/MS) [5][6][7]9,13]. The drawbacks of some of these methods are high sample volumes and elaborate, timeconsuming clean-up techniques that are difficult to automate.…”

“…Several methods were dedicated to the study of free (unbound) concentrations after ultrafiltration [14] or microdialysis [6,7,13]. A few methods included quantification of metabolites for pharmacokinetic studies [5,12]. Some early publications described on-line extraction by column-switching techniques for anaesthetics in serum by HPLC-UV techniques [14][15][16][17][18].…”

Simultaneous Determination of Ropivacaine, Bupivacaine and Dexamethasone in Biodegradable PLGA Microspheres by High Performance Liquid Chromatography

“…Many methods, including HPLC-UV, 17 20) HPLC-MS, 21 24) GC 25) and GC-MS, 26 28) were reported for the analysis of BUP 17,22,25) , ROP 17,18,21,22,24,27,28) or DXM 20,23,26,29) in biological matrix (blood, urine) separately. However, these methods are not suitable for the simultaneous analysis of ROP, BUP and DXM in PLGA microspheres because of the limitation of complex sample preparation or long analysis time.…”

Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction

“…The anesthetics have been analysed by gas chromatography [3][4][5][6][7][8][9][10][11][12][13][14][15][16], liquid chromatography [17][18][19][20][21][22][23][24][25] or capillary electrophoreses [26,27].…”

“…As methods for sample preparation liquid-liquid extraction [6,8,9,21], solid-phase extraction [10][11][12][13]19] and solid-phase microextraction [3][4][5]7,16] have been used.…”