Determination of Selenium in Blood Serum of Children with Acute Leukemia and Effect of Chemotherapy on Serum Selenium Level

Pazirandeh, Ali; Nejad, M. Assadi; Vossogh, Parvaneh

doi:10.1016/s0946-672x(99)80043-1

Cited by 25 publications

(17 citation statements)

References 17 publications

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“…This study showed that serum Se level and GPX activity were increased after induction therapy with statistically significant difference (Table 4) and this is in agreement with Pazirandeh and colleagues [28].…”

Section: Discussionsupporting

confidence: 92%

Selenium and Glutathione Peroxidase Status in Adult Egyptian Patients with Acute Myeloid Leukemia

Asfour

El-kholy

Ayoub

et al. 2009

Biol Trace Elem Res

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This study was undertaken to evaluate selenium (Se) and glutathione peroxidase (GPX) status in patients with newly diagnosed acute myeloid leukemia (AML) before and after induction therapy. Twenty-five patients with newly diagnosed AML and 15 healthy age- and sex-matched control subjects were included in this study. Serum Se level by the graphite furnace atomic absorption spectrometric technique and GPX activity by an adaptation of Beutler method was performed for the patients before and after receiving the induction therapy. Serum Se level was significantly lower in patients with AML versus control subjects (63.1 ± 8.8 versus 77 ± 8.8 μg/L before therapy with a P value <0.01 and 69 ± 6.8 versus 77 ± 8.8 μg/L after therapy with a P value <0.01).GPX activity was significantly lower in patients with AML versus control subjects (1.6 ± 0.4 versus 3.4 ± 0.7 μ/g protein pretreatment with a P value <0.01 and 1.9 ± 0.6 versus 3.4 ± 0.7 μ/g protein post induction treatment with P value <0.01).Se level and GPX activity significantly increased in AML patients after treatment. Patients who accomplished complete remission after induction harbored significantly higher Se levels than resistant patients before and after treatment. There was no significant correlation between serum Se level and GPX activity. Decreased Se level and reduced GPX activity in AML patients support the association of carcinogenesis and subnormal Se states.

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Section: Discussionsupporting

confidence: 92%

Selenium and Glutathione Peroxidase Status in Adult Egyptian Patients with Acute Myeloid Leukemia

Asfour

El-kholy

Ayoub

et al. 2009

Biol Trace Elem Res

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“…The results of this study are in agreement with some studies demonstrating low Se levels in children with cancer (20)(21)(22)(23)(24)(25)(26). One study showed that Se deficiency was common among newly diagnosed pediatric cancer patients, Se levels were lower in widespread disease than localized disease, and low Se levels were more prevalent in widespread disease patients than in localized disease patients (27).…”

Section: Discussionsupporting

confidence: 92%

The Prevalence of Low Selenium Levels in Adult Patients Undergoing Bone Marrow Transplantation: A Brief Communication

Hadjibabaie

Iravani

Shamshiri

et al. 2008

Nutrition and Cancer

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Selenium (Se) is an essential trace element, and its deficiency is considered to be important in various types of cancer. There are just a few data regarding this issue among adult patients with hematological malignancy. Serum Se levels were determined in 22 adult patients candidates for bone marrow transplantation (BMT) in Iran. The mean serum Se levels before BMT was 19.91 microg/l (from 12.00 to 62.00 microg/l), and almost all the patients had low Se serum levels (normal serum Se level: 46-143 microg/l). The level of Se 20 days after BMT was 22.53 microg/l, which did not show any significant changes. Most of the patients did not suffer from malnutrition, as they had mostly normal albumin levels. Even though the results of this study showed that Se deficiency is common among our hematological malignant patients, it can not be concluded that these low Se levels are causally related to cancers for which BMT is undertaken. Further studies are needed to evaluate the Se levels at diagnosis before treatment effects.

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“…Selenium concentrations in the literature are not considered if only presented in the form of figures [154]. The interested reader, who would like to obtain more information about factors influencing blood selenium concentrations, is referred to a literature review [5], or to the following references for recent values in: children: [37][38][39][40][41][42][43][44][45][46]48,149,[155][156][157][158][159][160]; adolescents: [161][162][163][164] or elderly people: [49][50][51][52][53][54][55][56][57][58][165][166][167][168][169][170][171][172][173][174][175][176].…”

Section: Selenium Concentrations In Healthy Adults From Other Europeamentioning

confidence: 99%

Comparison of the serum selenium content of healthy adults living in the Antwerp region (Belgium) with recent literature data

Cauwenbergh

Robberecht

Vlaslaer

et al. 2004

Journal of Trace Elements in Medicine and Biology

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Determination of Selenium in Blood Serum of Children with Acute Leukemia and Effect of Chemotherapy on Serum Selenium Level

Cited by 25 publications

References 17 publications

Selenium and Glutathione Peroxidase Status in Adult Egyptian Patients with Acute Myeloid Leukemia

Selenium and Glutathione Peroxidase Status in Adult Egyptian Patients with Acute Myeloid Leukemia

The Prevalence of Low Selenium Levels in Adult Patients Undergoing Bone Marrow Transplantation: A Brief Communication

Comparison of the serum selenium content of healthy adults living in the Antwerp region (Belgium) with recent literature data

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