Determination of selenium(IV) in pharmaceuticals and premixes by micellar liquid chromatography

Validation of Micellar LC-Based Methods Applied to Analyze Foodstuffs

“…The use of micellar solutions as mobile phases in reversedphase LC is very attractive owing to the versatility of MLC because of the great variety of interactions between the solutes, micelles and stationary phase [1,2]. These mobile phases are appropriate for both hydrophobic and hydrophilic analytes, thereby covering a wide range of compounds, as nutrients [3][4][5][6][7][8], drugs [9][10][11][12][13][14][15][16], additives [17,18] and toxics [19][20][21][22][23][24][25][26][27]. The conditions can even be optimized to separate different analytes in the same run [4][5][6][10][11][12][13][14][15][17][18][19]24,27].…”

“…Another advantage is the use of micellar solutions as the solvent in a matrix, as hydrophobic compounds are also solubilized due to their interactions with the organic environment inside the micelle. This is useful in complex samples such as foodstuffs [3][4][5][6][7][8]11,[14][15][16][17][18][19][20][21][23][24][25][26][27]. Thus, extraction is avoided, expediting the experimental procedure, improving the reproducibility and decreasing the amount of organic solvent.…”

“…Thus, extraction is avoided, expediting the experimental procedure, improving the reproducibility and decreasing the amount of organic solvent. MLC-based methods mainly use UVvisible absorbance [3,4,[6][7][8]12,13,15,[18][19][20][21][22][23][24][25][26], fluorescence [11,14] or electrochemistry [5] detection. MLC cannot be coupled to MS because the surfactant and the buffer salt easily dirty the detector; therefore, the use of this expensive instrumentation is avoided.…”

“…due to the lower cost of instrumentation adn reagents, the reduced environ mental impact of the chemicals and the expedition of the e xperimental procedure [1][2][3][4][6][7][8][9][10][11][12][13]15,16,[18][19][20][21][22][23]25,26,28].…”

Development of a dual-analyte fluorescent sensor for the determination of bioactive nitrite and selenite in water samples

“…1 for both reactions). Thanks to this reactivity, the compound has been successfully used in numerous occasions to detect and quantify either nitrite or selenite in biological and environmental samples [24][25][26][27][28][29][30][31]. However, despite these assays offer great sensitivity and versatility, they show several drawbacks such as the poor solubility of DAN in water and its toxicity.…”