1999
DOI: 10.1016/s0731-7085(98)00231-3
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Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis

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Cited by 83 publications
(59 citation statements)
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“…), is a mixture of flavonolignans including silybin, silychristin, isosilybin, silydianin, taxifolin, and various derivatives of these components (1)(2)(3). Silymarin as well as silybin, the main active component comprising about 33% of total silymarin weight (4), is used clinically as a hepatoprotector to treat liver injuries and chronic hepatitis.…”
Section: Introductionmentioning
confidence: 99%
“…), is a mixture of flavonolignans including silybin, silychristin, isosilybin, silydianin, taxifolin, and various derivatives of these components (1)(2)(3). Silymarin as well as silybin, the main active component comprising about 33% of total silymarin weight (4), is used clinically as a hepatoprotector to treat liver injuries and chronic hepatitis.…”
Section: Introductionmentioning
confidence: 99%
“…High Performance Capillary Electrophoresis (HPCE) was used for determination of silymarin in the extract of S. marianum using borate buffer solution at pH 9. At this pH the flavonolignans having many phenolic groups in their structure were negatively charged (Quaglia et al, 1999). In these conditions isosilybin co-eluted together with silybin.…”
Section: Capillary Electrophoresis Analysismentioning
confidence: 92%
“…High Performance Liquid Chromatography (HPLC) was proposed as a method for determination of silymarin (Quaglia et al, 1999). Two reversed stationary phases, RP-18 and RP-8, were compared for resolution of all considered flavonolignans.…”
Section: High Performance Liquid Chromatography Analysismentioning
confidence: 99%
“…Moreover, inhibition of cancer cell growth in human prostate, skin, breast, and cervical cells was reported [6]. A number of methods utilizing HPLC and capillary electrophoresis were used for partial separation of the six components of silymarin [7,8], but the majority of these methods suffered from incomplete separation of silychristin, silydianin, and the two diastereoisomers of silybin and isosilybin. Recent studies focused on quantifying each component of silymarin obtained from the fruits and seeds or in different commercial products using either HPLC or a newly developed capillary zone electrophoresis method [9][10][11].…”
Section: Introductionmentioning
confidence: 99%