Determination of single living cell’s dry/water mass using optofluidic chip

Song, Wuzhou; Liu, A. Q.; Swaminathan, S.; Lim, Chu Sing; Ayi, T. C.

doi:10.1063/1.2789287

Cited by 40 publications

(24 citation statements)

References 10 publications

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“…An optofluidic fiber based Mach-Zehnder interferometer has been used for measuring the dry/wet mass of a single living cell using. The device integrate a fiber optic trap, that capture a single living cell, and then the cell's refractive index and diameter are simultaneously determined by MZI [32]. Recently a new class of highly compact single-beam microfluidic Mach-Zehnder interferometer has been demonstrated.…”

Section: Optofluidic Interferometersmentioning

confidence: 99%

Optofluidics: a new tool for sensing

Testa¹,

Persichetti²,

Zeni

et al. 2013

SPIE Proceedings

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Over the last years optofluidics has emerged as a very promising field. The integration at microscopic level between optics and microfluidics provides a number of unique characteristics that cannot be obtained with solid materials only. This paper briefly reviews the state of the art on optofluidics for sensing applications. We first describe the different approaches in order to realized optofluidic waveguides. These waveguides allow an increased interaction efficiency between the light and the liquid substance that can be very useful in sensing applications (fluorescence, absorption spectroscopy, etc.). We then illustrate high sensitive optofluidic devices such as Mach-Zehnder interferometers, FabryPérot cavities and ring resonators. Examples of applications of optofluidic sensors for chemical and biological analysis are given.

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Section: Optofluidic Interferometersmentioning

confidence: 99%

Optofluidics: a new tool for sensing

Testa¹,

Persichetti²,

Zeni

et al. 2013

SPIE Proceedings

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show abstract

“…Improvement of the repeatability and stability is obtained at the cost of the additional fiber laser and the complicated setup. (11) In this study, a new Si microoptical bench with a robust basement is proposed to measure the absorption spectrum of cells in liquid.…”

Section: Introductionmentioning

confidence: 99%

Lifted Bottom of Microfluidic Channel for Cell Absorption Spectroscopy Using Optical Fibers

2017

Sensors and Materials

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A Si microoptical bench has been developed for measuring the absorption spectrum of cells in suspension. Optical fibers are the elements for constructing a light path inside a Si chip. The sensing light is introduced, transmitted through the sample, and detected. The light propagates in the core. A thick surrounding cladding protects the beam from optical disturbance. In many cases, the cells in suspension tend to sink to the bottom of the microfluidic channel because their density is higher than that of water. For bringing the cell in the sensing light beam, the bottom of the microfluidic channel is lifted up to the core height of the optical fiber in the device. The absorption caused by the chlorophyll of the chlorella is observed.

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“…[13][14][15][16][17][18][19][20] Consolidation of optics with microfluidics is difficult and requires meticulous research because of the delicacy and complexity of such devices. Optofluidics 21,22 is a versatile branch of microfluidics that benefits from the convergence of these two fields ͑i.e., optics and microfluidics͒, with the advantage of greatly increased simplicity in the fabrication of microoptical components ͑e.g., lens, waveguide͒.…”

Section: Introductionmentioning

confidence: 99%

Optofluidic tunable microlens by manipulating the liquid meniscus using a flared microfluidic structure

et al. 2010

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We have designed, demonstrated, and characterized a simple, novel in-plane tunable optofluidic microlens. The microlens is realized by utilizing the interface properties between two different fluids: CaCl 2 solution and air. A constant contact angle of ϳ90°is the pivotal factor resulting in the outward bowing and convex shape of the CaCl 2 solution-air interface. The contact angle at the CaCl 2 solution-air interface is maintained by a flared structure in the polydimethylsiloxane channel. The resulting bowing interface, coupled with the refractive index difference between the two fluids, results in effective in-plane focusing. The versatility of such a design is confirmed by characterizing the intensity of a traced beam experimentally and comparing the observed focal points with those obtained via ray-tracing simulations. With the radius of curvature conveniently controlled via fluid injection, the resulting microlens has a readily tunable focal length. This ease of operation, outstandingly low fluid usage, large range tunable focal length, and in-plane focusing ability make this lens suitable for many potential lab-on-a-chip applications such as particle manipulation, flow cytometry, and in-plane optical trapping.

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Determination of single living cell’s dry/water mass using optofluidic chip

Cited by 40 publications

References 10 publications

Optofluidics: a new tool for sensing

Optofluidics: a new tool for sensing

Lifted Bottom of Microfluidic Channel for Cell Absorption Spectroscopy Using Optical Fibers

Optofluidic tunable microlens by manipulating the liquid meniscus using a flared microfluidic structure

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