Determination of sulfonamide antibiotics by gas chromatography coupled with atomic emission detection

Chiavarino, Barbara; Crestoni, Maria Elisa; Marzio, Annito Di; Fornarini, Simonetta

doi:10.1016/s0378-4347(97)00568-9

Cited by 81 publications

(28 citation statements)

References 27 publications

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“…Therefore, there is a constant requirement for good analytical protocols based on efficient analytical processes (sensitive, selective, fast and inexpensive) by legislation, health authorities and companies operating in the food market. Many methods have been described for determination of sulfonamides in biological samples including high performance liquid chromatography (HPLC) [4,5], gas chromatography (GC) [6,7], liquid chromatography-mass spectrometry (LC-MS) [8], and capillary electrophoresis (CE) [9]. Because of the complexity of food matrices and contaminants presented in food at low concentration (ng g g −1 ) levels, all sulfonamide analysis requires extensive sample pretreatment, for example liquid-liquid extraction and solid-phase extraction (SPE) [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed

Kong

Gao

et al. 2012

Journal of Chromatography A

246

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed

Kong

Gao

et al. 2012

Journal of Chromatography A

246

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“…In the past decades, various methods have been employed to determine sulfonamide drugs such as gas chromatography-mass spectrometry (GC-MS) [11,12], GC-atomic emission detection (GC-AED) [13], high-performance liquid chromatography ultraviolet detection (HPLC-UV) [14,15] or fluorescence detection [16], liquid chromatography-mass spectrometry (LC-MS) [17], capillary electrophoresis-ultraviolet detection (CE-UV) [18], etc. Prior to GC analysis, derivatization of non-volatile and thermally labile sulfonamides is required.…”

Section: Introductionmentioning

confidence: 99%

Hollow fiber supported ionic liquid membrane microextraction for determination of sulfonamides in environmental water samples by high-performance liquid chromatography

Tao¹,

Liu²,

Hu³

et al. 2009

Journal of Chromatography A

148

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a b s t r a c tBy using ionic liquid as membrane liquid and tri-n-octylphosphine oxide (TOPO) as additive, hollow fiber supported liquid phase microextraction (HF-LPME) was developed for the determination of five sulfonamides in environmental water samples by high-performance liquid chromatography with ultraviolet detection The extraction solvent and the parameters affecting the extraction enrichment factor such as the type and amount of carrier, pH and volume ratio of donor phase and acceptor phase, extraction time, salt-out effect and matrix effect were optimized. Under the optimal extraction conditions (organic liquid membrane phase: [C 8 MIM] [PF 6 ] with 14% TOPO (w/v); donor phase: 4 mL, pH 4.5 KH 2 PO 4 with 2 M Na 2 SO 4 ; acceptor phase: 25 L, pH 13 NaOH; extraction time: 8 h), low detection limits (0.1-0.4 g/L, RSD ≤ 5%) and good linear range (1-2000 ng/mL, R 2 ≥ 0.999) were obtained for all the analytes. The presence of humic acid (0-25 mg/L dissolved organic carbon) and bovine serum albumin (0-100 g/mL) had no significant effect on the extraction efficiency. Good spike recoveries over the range of 82.2-103.2% were obtained when applying the proposed method on five real environmental water samples. These results indicated that this present method was very sensitive and reliable with good repeatabilities and excellent clean-up in water samples. The proposed method confirmed hollow fiber supported ionic liquid membrane based LPME to be robust to monitoring trace levels of sulfadiazine, sulfamerazine, sulfamethazine, sulfadimethoxine and sulfamethoxazole in aqueous samples.

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“…The methods include enzyme immunoassay (Endoh et al, 1994 ), gas chromatography with atomic emission (Chiavarino et al, 1998),Gas chromatography-Mass spectroscopy (Mooser et al, 1993), TLC (Schlatterer et al, 1982), HPTLC (Van Poucke et al, 1989), LC (Edder et al, 1997 andMengelers et al, 1993), HPLC (Van der Steuijt et al, 1987, Shao et al, 1993and Lin et al, 1995, HPLC-FD (Stoev et al, 2000), HPLC-photodiode array detection (Nishimura et al, 1996) and Flow injection sensor (Fernandez de Cordova et al, 2003). The chromatographic techniques were the most widely used .Although procedure is specific, most of it is time consuming and require multistage extraction procedure.…”

Section: Figure 1: Structural Formula Of the Pure Smxmentioning

confidence: 99%

Analytical Method Development for the Spectrophotometric Determination of Sulfamethoxazole in Bulk Drug and Pharmaceutical Preparation

Mehdi¹

2015

JCB

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A spectrophotometric method for the determination of Sulfamethaxazole (SMX) in bulk drug and in solid dosage was developed. The method was based on the condensation reaction between primary aromatic amine group present in drug with aromatic aldehyde, vanillin, to produce a yellow color. The resulting Schiff's base shown maximum absorption at 372nm. The reaction product is stable. The reaction was carried out in acetic acid and in 0.1M perchloric acid medium. The Beer's law was obeyed in the ranges 1.5-40 mg/L with the acceptable correlation coefficient r = 0.9993. The detection limit and limit of detection were 0.19 and 0.24 mg/L of SMX, respectively. The method was successfully applied to the determination of this compound in pharmaceutical formulation.

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Determination of sulfonamide antibiotics by gas chromatography coupled with atomic emission detection

Cited by 81 publications

References 27 publications

Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed

Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed

Hollow fiber supported ionic liquid membrane microextraction for determination of sulfonamides in environmental water samples by high-performance liquid chromatography

Analytical Method Development for the Spectrophotometric Determination of Sulfamethoxazole in Bulk Drug and Pharmaceutical Preparation

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