2020
DOI: 10.1002/rcm.8579
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Determination of synthetic cathinone α‐pyrrolidinovalero‐phenone and its metabolite in urine using solid‐phase extraction and gas chromatography–mass spectrometry

Abstract: Rationale The presence of α‐pyrrolidinovalerophenone (α‐PVP) and its metabolites in urine is evidence of the administration of α‐PVP. A toxicological challenge is that the metabolites of α‐PVP exhibit amphoteric properties, which make them unsuitable for detection using gas chromatography–mass spectrometry (GC/MS). In the study reported, proper derivatization and sample extraction were essential for improving the sensitivity for GC/MS analysis. Methods An automated solid‐phase extraction (SPE) method has been … Show more

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Cited by 8 publications
(3 citation statements)
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“…From an analytical perspective, given the extreme instability of numerous parent cathinones, specifically those featuring halogenated groups, the detection of these instability products and metabolites in the blood might be useful biomarkers and would greatly increase the detection windows for suspected SCt use. Indeed, dihydro-metabolites continue to be detected in forensic caseworks either in the presence or absence of parent drug [22][23][24][25].…”
Section: Discussionmentioning
confidence: 99%
“…From an analytical perspective, given the extreme instability of numerous parent cathinones, specifically those featuring halogenated groups, the detection of these instability products and metabolites in the blood might be useful biomarkers and would greatly increase the detection windows for suspected SCt use. Indeed, dihydro-metabolites continue to be detected in forensic caseworks either in the presence or absence of parent drug [22][23][24][25].…”
Section: Discussionmentioning
confidence: 99%
“…Over the past decade, regulatory challenges and health risk concerns related to NPSs have dramatically risen due to their widespread proliferation. Traditionally, the quantitative confirmation of NPSs in biological matrices has been carried out using hyphenated mass spectrometry with chromatography techniques in forensic laboratories. These approaches not only provide the sensitivity and accuracy necessary for screening analysis of many NPSs, but they have also led to the publication of methodologies for measuring specific emerging drug classes and a broad spectrum of drugs from different classes.…”
Section: Introductionmentioning
confidence: 99%
“…New psychoactive substances of synthetic cathinone are a kind of controlled drugs with strong excitatory and hallucinogenic effects. [1][2][3] The earliest cathinone designer drugs, methcathinone and 4-methyl methcathinone, were accidentally synthesized by scientists in the 1920s. 4 These two substances were initially used as antidepressantspecific medicines, but gradually flowed into the drug market.…”
Section: Introductionmentioning
confidence: 99%