Rapid detection of nine synthetic cathinones in blood and urine by direct analysis in real‐time‐tandem mass spectrometry

Ji, Jiahua; Zhang, Ying; Wang, Jifen

doi:10.1002/rcm.9136

Cited by 7 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The method was evaluated with conducted a systematic study of paper substrate-solvent combinations in the analysis of illicit drugs and chemical warfare agents to determine optimal conditions for different compound types. 59 Aside from paper spray, DART-MS has also been readily utilized in the rapid analysis of drugs, including for the detection of synthetic cathinones in blood and urine, 60 the analysis of benzodiazepines in plasma, 61 the detection of cannabinoids in various complex matrices 62 and for the analysis of illicit drugs in electronic cigarette aerosols. 63 Recently, the applications of ambient ionization to drugs analysis have extended beyond the laboratory, with research focusing on the development of hand-held tools and methods that could be used in the field for the analysis of real-world samples to truly test the feasibility of such techniques.…”

Section: Forensics and Securitymentioning

confidence: 99%

“…conducted a systematic study of paper substrate‐solvent combinations in the analysis of illicit drugs and chemical warfare agents to determine optimal conditions for different compound types. 59 Aside from paper spray, DART‐MS has also been readily utilized in the rapid analysis of drugs, including for the detection of synthetic cathinones in blood and urine, 60 the analysis of benzodiazepines in plasma, 61 the detection of cannabinoids in various complex matrices 62 and for the analysis of illicit drugs in electronic cigarette aerosols. 63 …”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

See 1 more Smart Citation

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

View full text Add to dashboard Cite

Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

show abstract

Section: Forensics and Securitymentioning

confidence: 99%

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

View full text Add to dashboard Cite

show abstract

“…Direct analysis in real time (DART), a versatile ion source for the analysis of materials in open air under ambient conditions, is proposed by Cody in 2005 . The results could be obtained quickly within 1 min by DART–MS without chromatographic separation, , which was very advantageous for quantification. − And, aside from being cumbersome and time-consuming, the major limitation of sample preparation is that sample extraction sometimes requires solvents that are not compatible with LC/GC systems. The advantage of DART is that the sample is not required to be evaporated unless it is required to be concentrated.…”

Section: Introductionmentioning

confidence: 99%

Automatic MDSPE Combined with DART–HRMS for the Rapid Quantitation of 21 Synthetic Cathinones in Urine

Li,

Lian,

Sheng

et al. 2023

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

A new, rapid, and automated method for the quantitation of 21 synthetic cathinones in urine was established using magnetic dispersive solid-phase extraction (MDSPE) in combination with direct analysis in real time-high-resolution mass spectrometry (DART−HRMS). Sample preparation and quantitation were verified by liquid chromatography−tandem mass spectrometry (LC-MS/MS). Methcathinone-D3, α-PVP-D8, and proadifen (SKF525A) were used as internal standards. Magnetic HLB extractant and NaH 2 PO 4 /NaOH buffer (0.2 M, pH 7) were used in automatic MDSPE. All 21 synthetic cathinones could be detected and analyzed by DART−HRMS in under 1 min. It was proven that the linearities of 21 synthetic cathinones were suitable (R 2 > 0.99) in the concentration ranges of 0.5−100 ng/mL or 1−100 ng/mL. The precision and accuracy values were all within ±15%, and the samples were stable under various conditions. The average time of each sample from preprocessing to completion of detection was approximately 2 min, allowing for rapid sample analysis. The relative error (RE) of the concentrations obtained by DART−HRMS and LC−MS/MS were within ±13.61%, and the linear coefficient (R) was 0.9964. The results of DART−HRMS and LC−MS/MS provided equivalent values at the 95% confidence level. In summary, a simple, fast, and convenient quantitation method via DART−HRMS was established. This application can be utilized to reduce backlogs and promote rapid case processing.

show abstract

“…Ambient ionization mass spectrometry (AIMS) is a new technology developed in 2004 which has provided approaches for sampling and ionization at atmospheric conditions that significantly decrease experimental complexity and time for sample analysis 33–36 . AIMS has been successfully applied to the distinction of drug adulteration 37–40 and identification analysis 41–44 . As an emerging technology in AIMS, chip‐based nano‐electrospray ionization tandem mass spectrometry (nano‐ESI‐MS/MS) 45,46 inherits the advantages of the traditional ESI approach and utilizes a chip‐based platform to achieve long‐term stable spraying of small volume samples and zero carryover perfusion analysis of simple samples, significantly reducing analysis time and the use of organic reagents 47–49 …”

Section: Introductionmentioning

confidence: 99%

“…[33][34][35][36] AIMS has been successfully applied to the distinction of drug adulteration [37][38][39][40] and identification analysis. [41][42][43][44] As an emerging technology in AIMS, chip-based nano-electrospray ionization tandem mass spectrometry (nano-ESI-MS/MS) 45,46 inherits the advantages of the traditional ESI approach and utilizes a chip-based platform to achieve long-term stable spraying of small volume samples and zero carryover perfusion analysis of simple samples, significantly reducing analysis time and the use of organic reagents. [47][48][49] The objective of this work was to develop a new method to rapidly distinguish BBP from other sources of BP using a chip-based nano-ESI-MS technology.…”

mentioning

confidence: 99%

Rapid identification of bear bile powder from other bile sources using chip‐based nano‐electrospray ionization tandem mass spectrometry

Zhang

Wei

et al. 2022

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Bear bile powder (BBP) is a widely used traditional Chinese medicine (TCM), and bile acids (BAs) are the main active components in BBP. Due to the scarcity of BBP resources, adulterations often occur in the market. Conventional methods to distinguish them are usually complicated and time-consuming. To enhance effectiveness and accuracy, a rapid and rough analytical method is desperately needed.Methods: In this study, a rapid strategy using chip-based nano-electrospray ionization tandem mass spectrometry (nano-ESI-MS/MS) was established to distinguish BBP from other sources of bile powder (BP). In addition, the results were further verified by ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry (UPLC/MS). Results:The precision of the chip-based nano-ESI-MS/MS method was validated to be acceptable with relative standard deviation (RSD) <15%. The distinction between BBP and other sources of BP, including common adulterants of pig bile powder (PBP), cattle bile powder (CBP), sheep bile powder (SBP), and chicken bile powder (CkBP), can be observed in the spectra. By using orthogonal partial least-squares discriminant analysis (OPLS-DA), more potential m/z markers were investigated. A BAs-related m/z marker of 498.3 was discovered as a typical differential molecular ion peak and was identified as tauroursodeoxycholic acid (TUDCA) and taurochenodeoxycholic acid (TCDCA) in BBP. Conclusions:The proposed strategy has simple sample pretreatment steps and significantly shortened analysis time. As an emerging technology, chip-based nano-ESI-MS not only provides a reference for the rapid distinction of adulterated Chinese medicines, but also provides some insights into the identification of other chemicals and foods. | INTRODUCTIONAdulteration of traditional Chinese medicines (TCMs), dietary supplement materials, and herbal products is a global problem for regulators. [1][2][3] These adulterant or counterfeit drugs can seriously compromise the therapeutic effects of natural medicines. Bear bile powder (BBP) is dried gallbladder bile collected from the black bear (Selenarctos thibetanus), the brown bear (Ursus arctos), or other species of Ursidae, under the category of animal drugs in TCMs. BBP has been used as a TCM for over 1300 years since the Tang Dynasty. [4][5][6] According to the theory of TCM, BBP has efficacies of "cleansing heat symptoms, calming the liver, and brightening eyes", and has been used in the clinic to treat convulsion, conjunctivitis, and pharyngolaryngitis in China. 7 Bile acids (BAs) are the main components in BBP, and

show abstract

Rapid detection of nine synthetic cathinones in blood and urine by direct analysis in real‐time‐tandem mass spectrometry

Cited by 7 publications

References 23 publications

Applications of ambient ionization mass spectrometry in 2021: An annual review

Applications of ambient ionization mass spectrometry in 2021: An annual review

Automatic MDSPE Combined with DART–HRMS for the Rapid Quantitation of 21 Synthetic Cathinones in Urine

Rapid identification of bear bile powder from other bile sources using chip‐based nano‐electrospray ionization tandem mass spectrometry

Contact Info

Product

Resources

About